{"molecules": [{"atc_classifications": ["L01EH03"], "availability_type": 1, "biotherapeutic": null, "black_box_warning": 0, "chemical_probe": 0, "chirality": 2, "cross_references": [{"xref_id": "tucatinib", "xref_name": "tucatinib", "xref_src": "DailyMed"}, {"xref_id": "human/EPAR/tukysa", "xref_name": "tukysa", "xref_src": "EMA"}], "dosed_ingredient": true, "first_approval": 2020, "first_in_class": 0, "helm_notation": null, "inorganic_flag": 0, "max_phase": "4.0", "molecule_chembl_id": "CHEMBL3989868", "molecule_hierarchy": {"active_chembl_id": "CHEMBL3989868", "molecule_chembl_id": "CHEMBL3989868", "parent_chembl_id": "CHEMBL3989868"}, "molecule_properties": {"alogp": "5.09", "aromatic_rings": 5, "full_molformula": "C26H24N8O2", "full_mwt": "480.53", "hba": 10, "hbd": 2, "heavy_atoms": 36, "mw_freebase": "480.53", "np_likeness_score": "-1.03", "num_ro5_violations": 1, "psa": "110.85", "qed_weighted": "0.36", "ro3_pass": "N", "rtb": 5}, "molecule_structures": {"canonical_smiles": 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0 0 0 0 0 0 0 0\n 1.8519 -1.7624 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 2.5438 -1.3131 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 2.5006 -0.4892 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 3.1925 -0.0399 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 3.2789 -1.6876 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 3.9708 -1.2383 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 3.9276 -0.4144 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 4.6195 0.0349 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 4.7059 -1.6128 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 5.3978 -1.1635 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 5.3546 -0.3396 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 5.5634 0.9788 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 4.7486 0.8497 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 5.9379 0.2437 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n -2.5585 0.7840 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n -5.2073 1.0939 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -5.2073 2.0638 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.3386 -0.1894 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 1 2 1 0\n 2 3 1 0\n 3 4 1 0\n 4 5 2 0\n 1 5 1 0\n 6 7 2 0\n 7 8 1 0\n 8 9 2 0\n 9 10 1 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inhibitors", "usan_substem": "-tinib", "usan_year": 2016, "veterinary": 0, "withdrawn_flag": false}], "page_meta": {"limit": 20, "next": null, "offset": 0, "previous": null, "total_count": 1}}