{"atc_classifications": ["C03AX01", "C03AA03"], "availability_type": 1, "biotherapeutic": null, "black_box_warning": 0, "chemical_probe": 0, "chirality": 2, "cross_references": [{"xref_id": "hydrochlorothiazide", "xref_name": "hydrochlorothiazide", "xref_src": "DailyMed"}], "dosed_ingredient": true, "first_approval": 1959, "first_in_class": 0, "helm_notation": null, "inorganic_flag": 0, "max_phase": "4.0", "molecule_chembl_id": "CHEMBL435", "molecule_hierarchy": {"active_chembl_id": "CHEMBL435", "molecule_chembl_id": "CHEMBL435", "parent_chembl_id": "CHEMBL435"}, "molecule_properties": {"alogp": "-0.35", "aromatic_rings": 1, "full_molformula": "C7H8ClN3O4S2", "full_mwt": "297.75", "hba": 5, "hbd": 3, "heavy_atoms": 17, "mw_freebase": "297.75", "np_likeness_score": "-1.23", "num_ro5_violations": 0, "psa": "118.36", "qed_weighted": "0.65", "ro3_pass": "N", "rtb": 1}, "molecule_structures": {"canonical_smiles": "NS(=O)(=O)c1cc2c(cc1Cl)NCNS2(=O)=O", "molfile": "\n     RDKit          2D\n\n 17 18  0  0  0  0  0  0  0  0999 V2000\n   -1.1250   -7.1417    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0\n    1.3208   -7.1417    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0\n   -0.5083   -7.5000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    0.7125   -7.5000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   -1.7458   -7.5000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n    0.1000   -7.1417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   -0.5083   -8.2042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    0.7167   -8.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    0.1000   -8.5625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   -1.4833   -6.5292    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n   -0.7750   -6.5292    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n   -1.1250   -8.5625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n   -1.7458   -8.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    1.6667   -6.5250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    0.9625   -6.5250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    1.9375   -7.4917    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n    1.3375   -8.5625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0\n  2  4  1  0\n  3  1  1  0\n  4  6  2  0\n  5  1  1  0\n  6  3  1  0\n  7  3  2  0\n  8  9  2  0\n  9  7  1  0\n 10  1  2  0\n 11  1  2  0\n 12 13  1  0\n 13  5  1  0\n 14  2  2  0\n 15  2  2  0\n 16  2  1  0\n 17  8  1  0\n  7 12  1  0\n  4  8  1  0\nM  END\n> <chembl_id>\nCHEMBL435\n\n> <chembl_pref_name>\nHYDROCHLOROTHIAZIDE", "standard_inchi": "InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)", "standard_inchi_key": "JZUFKLXOESDKRF-UHFFFAOYSA-N"}, "molecule_synonyms": [{"molecule_synonym": "Apo-hydro", "syn_type": "TRADE_NAME", "synonyms": "APO-HYDRO"}, {"molecule_synonym": "Apresazide", "syn_type": "OTHER", "synonyms": "APRESAZIDE"}, {"molecule_synonym": "Carozide", "syn_type": "OTHER", "synonyms": "CAROZIDE"}, {"molecule_synonym": "Chlorosulthiadil", "syn_type": "OTHER", "synonyms": "CHLOROSULTHIADIL"}, {"molecule_synonym": "Copalia-hct", "syn_type": "OTHER", "synonyms": "COPALIA-HCT"}, {"molecule_synonym": "Dafiro-hct", "syn_type": "OTHER", "synonyms": "DAFIRO-HCT"}, {"molecule_synonym": "Dihydrochlorurite", "syn_type": "OTHER", "synonyms": "DIHYDROCHLORURITE"}, {"molecule_synonym": "Esidrex", "syn_type": "TRADE_NAME", "synonyms": "ESIDREX"}, {"molecule_synonym": "Esidrix", "syn_type": "TRADE_NAME", "synonyms": "ESIDRIX"}, {"molecule_synonym": "Exforge-hct", "syn_type": "OTHER", "synonyms": "EXFORGE-HCT"}, {"molecule_synonym": "Hidroclorotiazida", "syn_type": "INN_SPANISH", "synonyms": "HIDROCLOROTIAZIDA"}, {"molecule_synonym": "Hidrotiazida", "syn_type": "OTHER", "synonyms": "HIDROTIAZIDA"}, {"molecule_synonym": "Hydrochlorothiaizide", "syn_type": "OTHER", "synonyms": "HYDROCHLOROTHIAIZIDE"}, {"molecule_synonym": "Hydrochlorothiazide", "syn_type": "ATC", "synonyms": "HYDROCHLOROTHIAZIDE"}, {"molecule_synonym": "Hydrochlorothiazide", "syn_type": "BNF", "synonyms": "HYDROCHLOROTHIAZIDE"}, {"molecule_synonym": "Hydrochlorothiazide", "syn_type": "FDA", "synonyms": "HYDROCHLOROTHIAZIDE"}, {"molecule_synonym": "Hydrochlorothiazide", "syn_type": "INN", "synonyms": "HYDROCHLOROTHIAZIDE"}, {"molecule_synonym": "Hydrochlorothiazide", "syn_type": "MERCK_INDEX", "synonyms": "HYDROCHLOROTHIAZIDE"}, {"molecule_synonym": "Hydrochlorothiazide", "syn_type": "OTHER", "synonyms": "HYDROCHLOROTHIAZIDE"}, {"molecule_synonym": "Hydrochlorothiazide", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE"}, {"molecule_synonym": "Hydrochlorothiazide component of accuretic", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF ACCURETIC"}, {"molecule_synonym": "Hydrochlorothiazide component of aldactazide", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF ALDACTAZIDE"}, {"molecule_synonym": "Hydrochlorothiazide component of aldoril", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF ALDORIL"}, {"molecule_synonym": "Hydrochlorothiazide component of amturnide", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF AMTURNIDE"}, {"molecule_synonym": "Hydrochlorothiazide component of apresazide", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF APRESAZIDE"}, {"molecule_synonym": "Hydrochlorothiazide component of apresoline-esidrix", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF APRESOLINE-ESIDRIX"}, {"molecule_synonym": "Hydrochlorothiazide component of avalide", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF AVALIDE"}, {"molecule_synonym": "Hydrochlorothiazide component of benicar hct", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF BENICAR HCT"}, {"molecule_synonym": "Hydrochlorothiazide component of cam-ap-es", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF CAM-AP-ES"}, {"molecule_synonym": "Hydrochlorothiazide component of diovan hct", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF DIOVAN HCT"}, {"molecule_synonym": "Hydrochlorothiazide component of dutoprol", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF DUTOPROL"}, {"molecule_synonym": "Hydrochlorothiazide component of dyazide", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF DYAZIDE"}, {"molecule_synonym": "Hydrochlorothiazide component of esimil", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF ESIMIL"}, {"molecule_synonym": "Hydrochlorothiazide component of exforge hct", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF EXFORGE HCT"}, {"molecule_synonym": "Hydrochlorothiazide component of h.r.-50", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF H.R.-50"}, {"molecule_synonym": "Hydrochlorothiazide component of hydralazine hydrochloride--reserpine", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF HYDRALAZINE HYDROCHLORIDE--RESERPINE"}, {"molecule_synonym": "Hydrochlorothiazide component of hydrap-es", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF HYDRAP-ES"}, {"molecule_synonym": "Hydrochlorothiazide component of hydra-zide", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF HYDRA-ZIDE"}, {"molecule_synonym": "Hydrochlorothiazide component of hydropres", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF HYDROPRES"}, {"molecule_synonym": "Hydrochlorothiazide component of hydro-reserp", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF HYDRO-RESERP"}, {"molecule_synonym": "Hydrochlorothiazide component of hydro-ride", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF HYDRO-RIDE"}, {"molecule_synonym": "Hydrochlorothiazide component of hydroserpine plus (r-h-h)", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF HYDROSERPINE PLUS (R-H-H)"}, {"molecule_synonym": "Hydrochlorothiazide component of hyzaar", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF HYZAAR"}, {"molecule_synonym": "Hydrochlorothiazide component of ibersartan/ zentiva", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF IBERSARTAN/ ZENTIVA"}, {"molecule_synonym": "Hydrochlorothiazide component of ifirmacombi", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF IFIRMACOMBI"}, {"molecule_synonym": "Hydrochlorothiazide component of irbesartan/-bms", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF IRBESARTAN/-BMS"}, {"molecule_synonym": "Hydrochlorothiazide component of irbesartan/ teva", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF IRBESARTAN/ TEVA"}, {"molecule_synonym": "Hydrochlorothiazide component of kervezide", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF KERVEZIDE"}, {"molecule_synonym": "Hydrochlorothiazide component of kinzalkomb", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF KINZALKOMB"}, {"molecule_synonym": "Hydrochlorothiazide component of lopressor hct", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF LOPRESSOR HCT"}, {"molecule_synonym": "Hydrochlorothiazide component of lotensin hct", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF LOTENSIN HCT"}, {"molecule_synonym": "Hydrochlorothiazide component of maxzide", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF MAXZIDE"}, {"molecule_synonym": "Hydrochlorothiazide component of micardis hct", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF MICARDIS HCT"}, {"molecule_synonym": "Hydrochlorothiazide component of micardisplus", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF MICARDISPLUS"}, {"molecule_synonym": "Hydrochlorothiazide component of moduretic", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF MODURETIC"}, {"molecule_synonym": "Hydrochlorothiazide component of monopril hct", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF MONOPRIL HCT"}, {"molecule_synonym": "Hydrochlorothiazide component of normozide", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF NORMOZIDE"}, {"molecule_synonym": "Hydrochlorothiazide component of oreticyl forte", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF ORETICYL FORTE"}, {"molecule_synonym": "Hydrochlorothiazide component of polycap", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF POLYCAP"}, {"molecule_synonym": "Hydrochlorothiazide component of prinzide", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF PRINZIDE"}, {"molecule_synonym": "Hydrochlorothiazide component of pritorplus", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF PRITORPLUS"}, {"molecule_synonym": "Hydrochlorothiazide component of quinaretic", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF QUINARETIC"}, {"molecule_synonym": "Hydrochlorothiazide component of rasitrio", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF RASITRIO"}, {"molecule_synonym": "Hydrochlorothiazide component of riprazo", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF RIPRAZO"}, {"molecule_synonym": "Hydrochlorothiazide component of ser-a-gen", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF SER-A-GEN"}, {"molecule_synonym": "Hydrochlorothiazide component of ser-ap-es", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF SER-AP-ES"}, {"molecule_synonym": "Hydrochlorothiazide component of serpasil-esidrix", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF SERPASIL-ESIDRIX"}, {"molecule_synonym": "Hydrochlorothiazide component of sprimeo-hct", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF SPRIMEO-HCT"}, {"molecule_synonym": "Hydrochlorothiazide component of tekturna hct", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF TEKTURNA HCT"}, {"molecule_synonym": "Hydrochlorothiazide component of teveten hct", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF TEVETEN HCT"}, {"molecule_synonym": "Hydrochlorothiazide component of tolucombi", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF TOLUCOMBI"}, {"molecule_synonym": "Hydrochlorothiazide component of tribenzor", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF TRIBENZOR"}, {"molecule_synonym": "Hydrochlorothiazide component of unipres", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF UNIPRES"}, {"molecule_synonym": "Hydrochlorothiazide component of uniretic", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF UNIRETIC"}, {"molecule_synonym": "Hydrochlorothiazide component of vaseretic", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF VASERETIC"}, {"molecule_synonym": "Hydrochlorothiazide component of viskazide", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF VISKAZIDE"}, {"molecule_synonym": "Hydrochlorothiazide component of zestoretic", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF ZESTORETIC"}, {"molecule_synonym": "Hydrochlorothiazide component of ziac", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE COMPONENT OF ZIAC"}, {"molecule_synonym": "Hydrochlorothiazide intensol", "syn_type": "TRADE_NAME", "synonyms": "HYDROCHLOROTHIAZIDE INTENSOL"}, {"molecule_synonym": "Hydrochlorothiazidum", "syn_type": "OTHER", "synonyms": "HYDROCHLOROTHIAZIDUM"}, {"molecule_synonym": "Hydrochlorthiazide", "syn_type": "OTHER", "synonyms": "HYDROCHLORTHIAZIDE"}, {"molecule_synonym": "Hydro-d", "syn_type": "TRADE_NAME", "synonyms": "HYDRO-D"}, {"molecule_synonym": "Hydrodiuril", "syn_type": "TRADE_NAME", "synonyms": "HYDRODIURIL"}, {"molecule_synonym": "Hydrosaluric", "syn_type": "TRADE_NAME", "synonyms": "HYDROSALURIC"}, {"molecule_synonym": "Idrotiazide", "syn_type": "OTHER", "synonyms": "IDROTIAZIDE"}, {"molecule_synonym": "Imprida-hct", "syn_type": "OTHER", "synonyms": "IMPRIDA-HCT"}, {"molecule_synonym": "Lotensin hct", "syn_type": "OTHER", "synonyms": "LOTENSIN HCT"}, {"molecule_synonym": "Megadiuril", "syn_type": "OTHER", "synonyms": "MEGADIURIL"}, {"molecule_synonym": "Microzide", "syn_type": "TRADE_NAME", "synonyms": "MICROZIDE"}, {"molecule_synonym": "Newtolide", "syn_type": "OTHER", "synonyms": "NEWTOLIDE"}, {"molecule_synonym": "NSC-53477", "syn_type": "RESEARCH_CODE", "synonyms": "NSC-53477"}, {"molecule_synonym": "Oretic", "syn_type": "TRADE_NAME", "synonyms": "ORETIC"}, {"molecule_synonym": "Pantemon", "syn_type": "OTHER", "synonyms": "PANTEMON"}, {"molecule_synonym": "Rasilez-hct", "syn_type": "OTHER", "synonyms": "RASILEZ-HCT"}, {"molecule_synonym": "Servithiazid", "syn_type": "OTHER", "synonyms": "SERVITHIAZID"}, {"molecule_synonym": "SU-5879", "syn_type": "RESEARCH_CODE", "synonyms": "SU-5879"}, {"molecule_synonym": "Unipres", "syn_type": "OTHER", "synonyms": "UNIPRES"}, {"molecule_synonym": "Vetidrex", "syn_type": "OTHER", "synonyms": "VETIDREX"}, {"molecule_synonym": "Ziac", "syn_type": "TRADE_NAME", "synonyms": "ZIAC"}, {"molecule_synonym": "Zide", "syn_type": "TRADE_NAME", "synonyms": "ZIDE"}], "molecule_type": "Small molecule", "natural_product": 1, "oral": true, "orphan": 0, "parenteral": false, "polymer_flag": 0, "pref_name": "HYDROCHLOROTHIAZIDE", "prodrug": 0, "structure_type": "MOL", "therapeutic_flag": true, "topical": false, "usan_stem": "-thiazide", "usan_stem_definition": "diuretics (thiazide derivatives)", "usan_substem": "-thiazide", "usan_year": null, "veterinary": 0, "withdrawn_flag": false}