{"atc_classifications": ["B01AD02", "S01XA13"], "availability_type": 1, "biotherapeutic": {"biocomponents": [], "description": "Tissue-type plasminogen activator precursor (tPA) (t-PA) (t-plasminogen activator) (Alteplase) (Reteplase)", "helm_notation": null, "molecule_chembl_id": "CHEMBL1201593"}, "black_box_warning": 0, "chemical_probe": 0, "chirality": 1, "cross_references": [{"xref_id": "alteplase", "xref_name": "alteplase", "xref_src": "DailyMed"}], "dosed_ingredient": true, "first_approval": 1996, "first_in_class": 0, "helm_notation": null, "inorganic_flag": 0, "max_phase": "4.0", "molecule_chembl_id": "CHEMBL1201593", "molecule_hierarchy": {"active_chembl_id": "CHEMBL1201593", "molecule_chembl_id": "CHEMBL1201593", "parent_chembl_id": "CHEMBL1201593"}, "molecule_properties": null, "molecule_structures": null, "molecule_synonyms": [{"molecule_synonym": "Actilyse", "syn_type": "TRADE_NAME", "synonyms": "ACTILYSE"}, {"molecule_synonym": "Actilyse cathflo", "syn_type": "TRADE_NAME", "synonyms": "ACTILYSE CATHFLO"}, {"molecule_synonym": "Activase", "syn_type": "TRADE_NAME", "synonyms": "ACTIVASE"}, {"molecule_synonym": "Alteplasa", "syn_type": "INN_SPANISH", "synonyms": "ALTEPLASA"}, {"molecule_synonym": "Alteplase", "syn_type": "ATC", "synonyms": "ALTEPLASE"}, {"molecule_synonym": "Alteplase", "syn_type": "BAN", "synonyms": "ALTEPLASE"}, {"molecule_synonym": "Alteplase", "syn_type": "BNF", "synonyms": "ALTEPLASE"}, {"molecule_synonym": "Alteplase", "syn_type": "FDA", "synonyms": "ALTEPLASE"}, {"molecule_synonym": "Alteplase", "syn_type": "INN", "synonyms": "ALTEPLASE"}, {"molecule_synonym": "Alteplase", "syn_type": "OTHER", "synonyms": "ALTEPLASE"}, {"molecule_synonym": "Alteplase", "syn_type": "USAN", "synonyms": "ALTEPLASE"}, {"molecule_synonym": "Alteplase", "syn_type": "USP", "synonyms": "ALTEPLASE"}, {"molecule_synonym": "Alteplase for injection", "syn_type": "OTHER", "synonyms": "ALTEPLASE FOR INJECTION"}, {"molecule_synonym": "Alteplase (genetical recombination)", "syn_type": "JAN", "synonyms": "ALTEPLASE (GENETICAL RECOMBINATION)"}, {"molecule_synonym": "Alteplase, recombinant", "syn_type": "OTHER", "synonyms": "ALTEPLASE, RECOMBINANT"}, {"molecule_synonym": "Alteplase,recombinant", "syn_type": "OTHER", "synonyms": "ALTEPLASE,RECOMBINANT"}, {"molecule_synonym": "Cathflo activase", "syn_type": "TRADE_NAME", "synonyms": "CATHFLO ACTIVASE"}, {"molecule_synonym": "Ec 3.4.21.68", "syn_type": "OTHER", "synonyms": "EC 3.4.21.68"}, {"molecule_synonym": "RT-PA", "syn_type": "RESEARCH_CODE", "synonyms": "RT-PA"}, {"molecule_synonym": "Tissue plasminogen activator alteplase", "syn_type": "MERCK_INDEX", "synonyms": "TISSUE PLASMINOGEN ACTIVATOR ALTEPLASE"}], "molecule_type": "Enzyme", "natural_product": 0, "oral": false, "orphan": 0, "parenteral": true, "polymer_flag": 0, "pref_name": "ALTEPLASE", "prodrug": 0, "structure_type": "SEQ", "therapeutic_flag": true, "topical": false, "usan_stem": "-ase", "usan_stem_definition": "enzymes: tissue-type plasminogen activators", "usan_substem": "-ase (-teplase)", "usan_year": 1989, "veterinary": 0, "withdrawn_flag": false}