{"molecules": [{"atc_classifications": ["A06AD11", "A06AD61"], "availability_type": 1, "biotherapeutic": null, "black_box_warning": 0, "chemical_probe": 0, "chirality": 1, "cross_references": [{"xref_id": "lactulose", "xref_name": "lactulose", "xref_src": "DailyMed"}], "dosed_ingredient": true, "first_approval": 1976, "first_in_class": 0, "helm_notation": null, "inorganic_flag": 0, "max_phase": "4.0", "molecule_chembl_id": "CHEMBL296306", "molecule_hierarchy": {"active_chembl_id": "CHEMBL296306", "molecule_chembl_id": "CHEMBL296306", "parent_chembl_id": "CHEMBL296306"}, "molecule_properties": {"alogp": "-5.40", "aromatic_rings": 0, "full_molformula": "C12H22O11", "full_mwt": "342.30", "hba": 11, "hbd": 8, "heavy_atoms": 23, "mw_freebase": "342.30", "np_likeness_score": "2.17", "num_ro5_violations": 2, "psa": "189.53", "qed_weighted": "0.24", "ro3_pass": "N", "rtb": 5}, "molecule_structures": {"canonical_smiles": "OC[C@H]1O[C@@H](O[C@@H]2[C@@H](CO)O[C@](O)(CO)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O", "molfile": "\n RDKit 2D\n\n 23 24 0 0 0 0 0 0 0 0999 V2000\n -0.4604 -0.0562 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -1.1749 0.3562 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n -1.8893 -0.0562 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -1.8894 -0.8812 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -1.1749 -1.2937 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -0.4604 -0.8812 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -2.6038 0.3562 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -2.6038 -1.2937 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 0.2541 0.3562 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n -1.1749 -2.1187 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 0.2541 -1.2937 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n -3.3183 -0.0562 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 1.2706 2.1187 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 0.6032 1.6337 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.8581 0.8492 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1.6831 0.8492 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1.9380 1.6337 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -0.1814 1.8887 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 2.7226 1.8887 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 2.1680 0.1817 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n -0.7945 1.3366 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 2.5214 1.0504 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 3.3183 1.2639 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 1 2 1 0\n 6 1 1 0\n 2 3 1 0\n 3 4 1 0\n 4 5 1 0\n 5 6 1 0\n 3 7 1 1\n 4 8 1 1\n 1 9 1 1\n 5 10 1 1\n 6 11 1 6\n 7 12 1 0\n 13 14 1 0\n 13 17 1 0\n 14 15 1 0\n 15 16 1 0\n 16 17 1 0\n 15 9 1 6\n 14 18 1 1\n 17 19 1 1\n 16 20 1 1\n 18 21 1 0\n 17 22 1 6\n 22 23 1 0\nM END\n> \nCHEMBL296306\n\n> \nLACTULOSE", "standard_inchi": "InChI=1S/C12H22O11/c13-1-4-6(16)7(17)8(18)11(21-4)22-9-5(2-14)23-12(20,3-15)10(9)19/h4-11,13-20H,1-3H2/t4-,5-,6+,7+,8-,9-,10+,11+,12-/m1/s1", "standard_inchi_key": "JCQLYHFGKNRPGE-FCVZTGTOSA-N"}, "molecule_synonyms": [{"molecule_synonym": "4-galactosyl fructose", "syn_type": "OTHER", "synonyms": "4-GALACTOSYL FRUCTOSE"}, {"molecule_synonym": "Acilac", "syn_type": "TRADE_NAME", "synonyms": "ACILAC"}, {"molecule_synonym": "Bifiteral", "syn_type": "TRADE_NAME", "synonyms": "BIFITERAL"}, {"molecule_synonym": "Cephulac", "syn_type": "TRADE_NAME", "synonyms": "CEPHULAC"}, {"molecule_synonym": "Cholac", "syn_type": "TRADE_NAME", "synonyms": "CHOLAC"}, {"molecule_synonym": "Chronulac", "syn_type": "TRADE_NAME", "synonyms": "CHRONULAC"}, {"molecule_synonym": "Constilac", "syn_type": "TRADE_NAME", "synonyms": "CONSTILAC"}, {"molecule_synonym": "Constulose", "syn_type": "TRADE_NAME", "synonyms": "CONSTULOSE"}, {"molecule_synonym": "Duphalac", "syn_type": "TRADE_NAME", "synonyms": "DUPHALAC"}, {"molecule_synonym": "Duphalac dry", "syn_type": "TRADE_NAME", "synonyms": "DUPHALAC DRY"}, {"molecule_synonym": "E966", "syn_type": "E_NUMBER", "synonyms": "E966"}, {"molecule_synonym": "Enulose", "syn_type": "TRADE_NAME", "synonyms": "ENULOSE"}, {"molecule_synonym": "Evalose", "syn_type": "TRADE_NAME", "synonyms": "EVALOSE"}, {"molecule_synonym": "Generlac", "syn_type": "TRADE_NAME", "synonyms": "GENERLAC"}, {"molecule_synonym": "Heptalac", "syn_type": "TRADE_NAME", "synonyms": "HEPTALAC"}, {"molecule_synonym": "Lactulosa", "syn_type": "INN_SPANISH", "synonyms": "LACTULOSA"}, {"molecule_synonym": "Lactulose", "syn_type": "ATC", "synonyms": "LACTULOSE"}, {"molecule_synonym": "Lactulose", "syn_type": "BAN", "synonyms": "LACTULOSE"}, {"molecule_synonym": "Lactulose", "syn_type": "BNF", "synonyms": "LACTULOSE"}, {"molecule_synonym": "Lactulose", "syn_type": "FDA", "synonyms": "LACTULOSE"}, {"molecule_synonym": "Lactulose", "syn_type": "INN", "synonyms": "LACTULOSE"}, {"molecule_synonym": "Lactulose", "syn_type": "JAN", "synonyms": "LACTULOSE"}, {"molecule_synonym": "Lactulose", "syn_type": "MERCK_INDEX", "synonyms": "LACTULOSE"}, {"molecule_synonym": "Lactulose", "syn_type": "OTHER", "synonyms": "LACTULOSE"}, {"molecule_synonym": "Lactulose", "syn_type": "TRADE_NAME", "synonyms": "LACTULOSE"}, {"molecule_synonym": "Lactulose", "syn_type": "USAN", "synonyms": "LACTULOSE"}, {"molecule_synonym": "Lactulose", "syn_type": "USP", "synonyms": "LACTULOSE"}, {"molecule_synonym": "Lactulose jp17", "syn_type": "JAN", "synonyms": "LACTULOSE JP17"}, {"molecule_synonym": "Laxilose", "syn_type": "TRADE_NAME", "synonyms": "LAXILOSE"}, {"molecule_synonym": "Laxose orange", "syn_type": "TRADE_NAME", "synonyms": "LAXOSE ORANGE"}, {"molecule_synonym": "Lemlax", "syn_type": "TRADE_NAME", "synonyms": "LEMLAX"}, {"molecule_synonym": "NSC-757082", "syn_type": "RESEARCH_CODE", "synonyms": "NSC-757082"}, {"molecule_synonym": "Osmolax", "syn_type": "TRADE_NAME", "synonyms": "OSMOLAX"}, {"molecule_synonym": "Portalac", "syn_type": "TRADE_NAME", "synonyms": "PORTALAC"}, {"molecule_synonym": "Regulose", "syn_type": "TRADE_NAME", "synonyms": "REGULOSE"}], "molecule_type": "Small molecule", "natural_product": 1, "oral": true, "orphan": 0, "parenteral": false, "polymer_flag": 0, "pref_name": "LACTULOSE", "prodrug": 0, "structure_type": "MOL", "therapeutic_flag": true, "topical": true, "usan_stem": null, "usan_stem_definition": null, "usan_substem": null, "usan_year": 1965, "veterinary": 0, "withdrawn_flag": false}], "page_meta": {"limit": 20, "next": null, "offset": 0, "previous": null, "total_count": 1}}