{"molecules": [{"atc_classifications": ["L01DA01"], "availability_type": 1, "biotherapeutic": null, "black_box_warning": 0, "chemical_probe": 0, "chirality": 1, "cross_references": [{"xref_id": "dactinomycin", "xref_name": "dactinomycin", "xref_src": "DailyMed"}], "dosed_ingredient": true, "first_approval": 1964, "first_in_class": 0, "helm_notation": null, "inorganic_flag": 0, "max_phase": "4.0", "molecule_chembl_id": "CHEMBL1554", "molecule_hierarchy": {"active_chembl_id": "CHEMBL1554", "molecule_chembl_id": "CHEMBL1554", "parent_chembl_id": "CHEMBL1554"}, "molecule_properties": {"alogp": null, "aromatic_rings": null, "full_molformula": "C62H86N12O16", "full_mwt": "1255.44", "hba": null, "hbd": null, "heavy_atoms": null, "mw_freebase": "1255.44", "np_likeness_score": null, "num_ro5_violations": null, "psa": null, "qed_weighted": null, "ro3_pass": null, "rtb": null}, "molecule_structures": {"canonical_smiles": "Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O", "molfile": "\n     RDKit          2D\n\n 92 98  0  0  1  0  0  0  0  0999 V2000\n    2.9875   -5.4000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    2.3875   -5.0375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    1.7667   -5.3875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    2.3917   -4.3250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n    2.9875   -6.1042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    1.7792   -3.9625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    1.7625   -6.0958    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    5.2917   -2.0083    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n   -1.5583   -2.7250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n    3.6083   -5.0458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    5.2833   -2.7167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   -0.9458   -2.3708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    2.3667   -6.4542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    1.7833   -3.2583    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    1.1500   -5.0292    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    4.6500   -3.7667    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n    0.2833   -2.3750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n    7.0833   -5.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    0.2667    0.4500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    5.2458   -4.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    0.8958   -1.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    5.2500   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    0.2792   -1.6750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    6.4792   -1.9583    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   -2.1458   -1.6042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   -0.9583    0.4417    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n    7.7042   -4.1417    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n    7.0917   -1.6083    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n   -2.7625   -1.2542    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n    2.4000   -2.9083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    1.1583   -4.3167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    8.3208   -3.7917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   -1.5750    0.7917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    4.2167   -5.4083    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n    2.4083   -2.2000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n    4.6625   -3.0583    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   -0.3333   -2.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   -2.1375   -2.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    5.8750   -1.5958    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    0.2708   -0.2583    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    6.4708   -4.8458    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    7.7000   -4.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   -0.3500    0.8000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    0.8875   -0.6042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    5.8583   -5.1958    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    8.3333   -2.4417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   -2.7458    0.1000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    1.1708   -2.8917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    5.8875   -3.0792    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n   -0.9417   -1.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    0.8750    0.8125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    7.0792   -5.9083    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    3.6125   -4.3417    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    0.5458   -3.9583    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    6.4667   -2.6667    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n   -1.5375   -1.2458    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    2.3625   -7.1625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n   -0.3333   -1.3208    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    5.8708   -3.7792    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n   -1.5833    1.5000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    8.9292   -4.1500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    3.0083   -3.2708    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    3.6000   -6.4625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n    0.5500   -3.2458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    4.0542   -2.6958    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   -0.3333   -3.4333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    4.7250   -1.5792    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   -1.7792   -3.4000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   -0.3542    1.5083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    8.3125   -5.2083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    1.1458   -6.4417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    7.0917   -3.7833    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   -0.9542   -0.2667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   -3.3708   -1.6167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    7.0958   -0.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   -2.7083   -2.7333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    5.6667   -0.9208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    4.9583   -0.9083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   -2.4833   -3.4042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    5.8542   -5.9042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    1.5000   -0.2458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   -0.0708   -4.3083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    4.0667   -1.9875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   -0.9500   -3.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    0.2750   -3.7917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    3.4375   -3.0375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    8.9250   -4.8583    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    8.3083   -5.9167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   -0.9708    1.8583    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    0.2542    1.8667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    6.6620   -0.9789    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0\n   -3.0327   -1.8668    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0\n  2  1  1  0\n  3  2  1  0\n  4  2  2  0\n  5  1  2  0\n  6  4  1  0\n  7 13  1  0\n  8 11  1  0\n  9 12  1  0\n 10  1  1  0\n 11 36  1  0\n 12 37  1  0\n 13  5  1  0\n 14  6  1  0\n 15  3  1  0\n 16 22  1  0\n 17 23  1  0\n 18 41  1  0\n 19 40  1  0\n 20 34  1  6\n 21 35  1  6\n 22 20  1  0\n 23 21  1  0\n 24 39  1  0\n 25 38  1  0\n 26 43  1  0\n 27 42  1  0\n 28 46  1  0\n 29 47  1  0\n 30 14  1  0\n 31  6  2  0\n 32 27  1  0\n 33 26  1  0\n 34 10  1  0\n 35 30  1  0\n 36 16  1  0\n 37 17  1  0\n 38  9  1  0\n 39  8  1  0\n 40 44  1  0\n 41 45  1  0\n 42 18  1  0\n 43 19  1  0\n 44 21  1  0\n 45 20  1  0\n 46 32  1  0\n 47 33  1  0\n 48 14  2  0\n 49 11  2  0\n 50 12  2  0\n 51 19  2  0\n 52 18  2  0\n 53 10  2  0\n 54 31  1  0\n 55 24  2  0\n 56 25  2  0\n 57 13  2  0\n 58 23  2  0\n 59 22  2  0\n 60 33  2  0\n 61 32  2  0\n 62 30  2  0\n 63  5  1  0\n 64 48  1  0\n 36 65  1  6\n 37 66  1  6\n 67  8  1  0\n 68  9  1  0\n 43 69  1  1\n 42 70  1  1\n 71  7  1  0\n 72 27  1  0\n 73 26  1  0\n 74 29  1  0\n 75 28  1  0\n 76 38  1  0\n 77 39  1  0\n 78 67  1  0\n 79 68  1  0\n 45 80  1  6\n 44 81  1  6\n 82 54  1  0\n 83 65  1  0\n 84 66  1  0\n 85 66  1  0\n 86 65  1  0\n 87 70  1  0\n 88 70  1  0\n 89 69  1  0\n 90 69  1  0\n  3  7  2  0\n 15 31  1  0\n 54 64  2  0\n 77 78  1  0\n 24 28  1  0\n 76 79  1  0\n 29 25  1  0\n 39 91  1  6\n 38 92  1  6\nM  END\n> <chembl_id>\nCHEMBL1554\n\n> <chembl_pref_name>\nDACTINOMYCIN", "standard_inchi": "InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1", "standard_inchi_key": "RJURFGZVJUQBHK-IIXSONLDSA-N"}, "molecule_synonyms": [{"molecule_synonym": "Actinomycin c1", "syn_type": "OTHER", "synonyms": "ACTINOMYCIN C1"}, {"molecule_synonym": "Actinomycin d", "syn_type": "JAN", "synonyms": "ACTINOMYCIN D"}, {"molecule_synonym": "Actinomycin d", "syn_type": "OTHER", "synonyms": "ACTINOMYCIN D"}, {"molecule_synonym": "Actinomycin-d", "syn_type": "OTHER", "synonyms": "ACTINOMYCIN-D"}, {"molecule_synonym": "Actinomycin i1", "syn_type": "OTHER", "synonyms": "ACTINOMYCIN I1"}, {"molecule_synonym": "Actinomycin iv", "syn_type": "OTHER", "synonyms": "ACTINOMYCIN IV"}, {"molecule_synonym": "Actinomycin x1", "syn_type": "OTHER", "synonyms": "ACTINOMYCIN X1"}, {"molecule_synonym": "Cosmegen", "syn_type": "TRADE_NAME", "synonyms": "COSMEGEN"}, {"molecule_synonym": "Cosmegen lyovac", "syn_type": "TRADE_NAME", "synonyms": "COSMEGEN LYOVAC"}, {"molecule_synonym": "Dactinomicina", "syn_type": "INN_SPANISH", "synonyms": "DACTINOMICINA"}, {"molecule_synonym": "Dactinomycin", "syn_type": "ATC", "synonyms": "DACTINOMYCIN"}, {"molecule_synonym": "Dactinomycin", "syn_type": "BAN", "synonyms": "DACTINOMYCIN"}, {"molecule_synonym": "Dactinomycin", "syn_type": "BNF", "synonyms": "DACTINOMYCIN"}, {"molecule_synonym": "Dactinomycin", "syn_type": "FDA", "synonyms": "DACTINOMYCIN"}, {"molecule_synonym": "Dactinomycin", "syn_type": "INN", "synonyms": "DACTINOMYCIN"}, {"molecule_synonym": "Dactinomycin", "syn_type": "MERCK_INDEX", "synonyms": "DACTINOMYCIN"}, {"molecule_synonym": "Dactinomycin", "syn_type": "OTHER", "synonyms": "DACTINOMYCIN"}, {"molecule_synonym": "Dactinomycin", "syn_type": "TRADE_NAME", "synonyms": "DACTINOMYCIN"}, {"molecule_synonym": "Dactinomycin", "syn_type": "USAN", "synonyms": "DACTINOMYCIN"}, {"molecule_synonym": "Dactinomycin", "syn_type": "USP", "synonyms": "DACTINOMYCIN"}, {"molecule_synonym": "Dactinomycine", "syn_type": "INN_FRENCH", "synonyms": "DACTINOMYCINE"}, {"molecule_synonym": "Dactinomycinum", "syn_type": "OTHER", "synonyms": "DACTINOMYCINUM"}, {"molecule_synonym": "Dilactone actinomycin d acid", "syn_type": "OTHER", "synonyms": "DILACTONE ACTINOMYCIN D ACID"}, {"molecule_synonym": "GNF-Pf-1977", "syn_type": "RESEARCH_CODE", "synonyms": "GNF-Pf-1977"}, {"molecule_synonym": "GNF-PF-2290", "syn_type": "RESEARCH_CODE", "synonyms": "GNF-PF-2290"}, {"molecule_synonym": "Meractinomycin", "syn_type": "OTHER", "synonyms": "MERACTINOMYCIN"}, {"molecule_synonym": "NCI-C04682", "syn_type": "RESEARCH_CODE", "synonyms": "NCI-C04682"}, {"molecule_synonym": "NSC-3053", "syn_type": "RESEARCH_CODE", "synonyms": "NSC-3053"}, {"molecule_synonym": "Oncostatin k", "syn_type": "OTHER", "synonyms": "ONCOSTATIN K"}], "molecule_type": "Protein", "natural_product": 1, "oral": false, "orphan": 0, "parenteral": true, "polymer_flag": 0, "pref_name": "DACTINOMYCIN", "prodrug": 0, "structure_type": "MOL", "therapeutic_flag": true, "topical": false, "usan_stem": "-mycin", "usan_stem_definition": "antibiotics (Streptomyces strain)", "usan_substem": "-mycin", "usan_year": 1964, "veterinary": 0, "withdrawn_flag": false}], "page_meta": {"limit": 20, "next": null, "offset": 0, "previous": null, "total_count": 1}}