<?xml version='1.0' encoding='utf-8'?>
<response><metabolisms><metabolism><drug_chembl_id>CHEMBL417</drug_chembl_id><enzyme_name/><met_comment/><met_conversion/><met_id>119</met_id><metabolism_refs><metabolism><ref_id>http://www.accessdata.fda.gov/drugsatfda_docs/nda/99/50-778_Ellence_biopharmr.pdf</ref_id><ref_type>OTHER</ref_type><ref_url>http://www.accessdata.fda.gov/drugsatfda_docs/nda/99/50-778_Ellence_biopharmr.pdf</ref_url></metabolism></metabolism_refs><metabolite_chembl_id>CHEMBL3508152</metabolite_chembl_id><metabolite_name>Doxorubicinol aglycone</metabolite_name><organism>Homo sapiens</organism><pathway_id>1</pathway_id><pathway_key>Fig. 2, p.19</pathway_key><substrate_chembl_id>CHEMBL3508141</substrate_chembl_id><substrate_name>Epidoxorubicinol, 4'-epiadriamycinol</substrate_name><target_chembl_id/><tax_id>9606</tax_id></metabolism><metabolism><drug_chembl_id>CHEMBL417</drug_chembl_id><enzyme_name/><met_comment/><met_conversion/><met_id>120</met_id><metabolism_refs><metabolism><ref_id>http://www.accessdata.fda.gov/drugsatfda_docs/nda/99/50-778_Ellence_biopharmr.pdf</ref_id><ref_type>OTHER</ref_type><ref_url>http://www.accessdata.fda.gov/drugsatfda_docs/nda/99/50-778_Ellence_biopharmr.pdf</ref_url></metabolism></metabolism_refs><metabolite_chembl_id>CHEMBL3508144</metabolite_chembl_id><metabolite_name>7d-Aon</metabolite_name><organism>Homo sapiens</organism><pathway_id>1</pathway_id><pathway_key>Fig. 2, p.19</pathway_key><substrate_chembl_id>CHEMBL417</substrate_chembl_id><substrate_name>Epirubicin</substrate_name><target_chembl_id/><tax_id>9606</tax_id></metabolism><metabolism><drug_chembl_id>CHEMBL417</drug_chembl_id><enzyme_name/><met_comment/><met_conversion/><met_id>121</met_id><metabolism_refs><metabolism><ref_id>http://www.accessdata.fda.gov/drugsatfda_docs/nda/99/50-778_Ellence_biopharmr.pdf</ref_id><ref_type>OTHER</ref_type><ref_url>http://www.accessdata.fda.gov/drugsatfda_docs/nda/99/50-778_Ellence_biopharmr.pdf</ref_url></metabolism></metabolism_refs><metabolite_chembl_id>CHEMBL3508153</metabolite_chembl_id><metabolite_name>Doxorubicin aglycone</metabolite_name><organism>Homo sapiens</organism><pathway_id>1</pathway_id><pathway_key>Fig. 2, p.19</pathway_key><substrate_chembl_id>CHEMBL417</substrate_chembl_id><substrate_name>Epirubicin</substrate_name><target_chembl_id/><tax_id>9606</tax_id></metabolism><metabolism><drug_chembl_id>CHEMBL417</drug_chembl_id><enzyme_name/><met_comment/><met_conversion/><met_id>122</met_id><metabolism_refs><metabolism><ref_id>http://www.accessdata.fda.gov/drugsatfda_docs/nda/99/50-778_Ellence_biopharmr.pdf</ref_id><ref_type>OTHER</ref_type><ref_url>http://www.accessdata.fda.gov/drugsatfda_docs/nda/99/50-778_Ellence_biopharmr.pdf</ref_url></metabolism></metabolism_refs><metabolite_chembl_id>CHEMBL6067664</metabolite_chembl_id><metabolite_name>Epirubicin glucuronide</metabolite_name><organism>Homo sapiens</organism><pathway_id>1</pathway_id><pathway_key>Fig. 2, p.19</pathway_key><substrate_chembl_id>CHEMBL417</substrate_chembl_id><substrate_name>Epirubicin</substrate_name><target_chembl_id/><tax_id>9606</tax_id></metabolism><metabolism><drug_chembl_id>CHEMBL417</drug_chembl_id><enzyme_name/><met_comment/><met_conversion/><met_id>123</met_id><metabolism_refs><metabolism><ref_id>http://www.accessdata.fda.gov/drugsatfda_docs/nda/99/50-778_Ellence_biopharmr.pdf</ref_id><ref_type>OTHER</ref_type><ref_url>http://www.accessdata.fda.gov/drugsatfda_docs/nda/99/50-778_Ellence_biopharmr.pdf</ref_url></metabolism></metabolism_refs><metabolite_chembl_id>CHEMBL3508141</metabolite_chembl_id><metabolite_name>Epidoxorubicinol, 4'-epiadriamycinol</metabolite_name><organism>Homo sapiens</organism><pathway_id>1</pathway_id><pathway_key>Fig. 2, p.19</pathway_key><substrate_chembl_id>CHEMBL417</substrate_chembl_id><substrate_name>Epirubicin</substrate_name><target_chembl_id/><tax_id>9606</tax_id></metabolism><metabolism><drug_chembl_id>CHEMBL417</drug_chembl_id><enzyme_name/><met_comment/><met_conversion/><met_id>124</met_id><metabolism_refs><metabolism><ref_id>http://www.accessdata.fda.gov/drugsatfda_docs/nda/99/50-778_Ellence_biopharmr.pdf</ref_id><ref_type>OTHER</ref_type><ref_url>http://www.accessdata.fda.gov/drugsatfda_docs/nda/99/50-778_Ellence_biopharmr.pdf</ref_url></metabolism></metabolism_refs><metabolite_chembl_id>CHEMBL6067664</metabolite_chembl_id><metabolite_name>Epirubicinol glucuronide</metabolite_name><organism>Homo sapiens</organism><pathway_id>1</pathway_id><pathway_key>Fig. 2, p.19</pathway_key><substrate_chembl_id>CHEMBL3508141</substrate_chembl_id><substrate_name>Epidoxorubicinol, 4'-epiadriamycinol</substrate_name><target_chembl_id/><tax_id>9606</tax_id></metabolism><metabolism><drug_chembl_id>CHEMBL417</drug_chembl_id><enzyme_name/><met_comment/><met_conversion/><met_id>125</met_id><metabolism_refs><metabolism><ref_id>http://www.accessdata.fda.gov/drugsatfda_docs/nda/99/50-778_Ellence_biopharmr.pdf</ref_id><ref_type>OTHER</ref_type><ref_url>http://www.accessdata.fda.gov/drugsatfda_docs/nda/99/50-778_Ellence_biopharmr.pdf</ref_url></metabolism></metabolism_refs><metabolite_chembl_id>CHEMBL3508143</metabolite_chembl_id><metabolite_name>7d-Aolon</metabolite_name><organism>Homo sapiens</organism><pathway_id>1</pathway_id><pathway_key>Fig. 2, p.19</pathway_key><substrate_chembl_id>CHEMBL3508141</substrate_chembl_id><substrate_name>Epidoxorubicinol, 4'-epiadriamycinol</substrate_name><target_chembl_id/><tax_id>9606</tax_id></metabolism><metabolism><drug_chembl_id>CHEMBL1639</drug_chembl_id><enzyme_name/><met_comment/><met_conversion>O-dealkylation</met_conversion><met_id>127</met_id><metabolism_refs><metabolism><ref_id>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_ClinPharmR_P2.pdf</ref_id><ref_type>OTHER</ref_type><ref_url>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_ClinPharmR_P2.pdf</ref_url></metabolism><metabolism><ref_id>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_ClinPharmR_P3.pdf</ref_id><ref_type>OTHER</ref_type><ref_url>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_ClinPharmR_P3.pdf</ref_url></metabolism></metabolism_refs><metabolite_chembl_id>CHEMBL3507701</metabolite_chembl_id><metabolite_name>Metabolite M4</metabolite_name><organism>Homo sapiens</organism><pathway_id>3</pathway_id><pathway_key>Fig. 9, p164/165</pathway_key><substrate_chembl_id>CHEMBL1639</substrate_chembl_id><substrate_name>Aliskiren, SPP100</substrate_name><target_chembl_id/><tax_id>9606</tax_id></metabolism><metabolism><drug_chembl_id>CHEMBL1639</drug_chembl_id><enzyme_name/><met_comment/><met_conversion>O-demethylation of the methoxypropoxy side chain</met_conversion><met_id>128</met_id><metabolism_refs><metabolism><ref_id>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_PharmR_P2.pdf</ref_id><ref_type>OTHER</ref_type><ref_url>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_PharmR_P2.pdf</ref_url></metabolism></metabolism_refs><metabolite_chembl_id>CHEMBL3507701</metabolite_chembl_id><metabolite_name>Metabolite M4</metabolite_name><organism>Callithrix jacchus</organism><pathway_id>2</pathway_id><pathway_key>Fig. 2.1.4.1, p.46</pathway_key><substrate_chembl_id>CHEMBL1639</substrate_chembl_id><substrate_name>Aliskiren, SPP100</substrate_name><target_chembl_id/><tax_id>9483</tax_id></metabolism><metabolism><drug_chembl_id>CHEMBL1639</drug_chembl_id><enzyme_name/><met_comment/><met_conversion>Oxidative dealkylation</met_conversion><met_id>129</met_id><metabolism_refs><metabolism><ref_id>http://www.accessdata.fda.gov/drugsatfda_docs/nda/99/50-778_Ellence_biopharmr.pdf</ref_id><ref_type>OTHER</ref_type><ref_url>http://www.accessdata.fda.gov/drugsatfda_docs/nda/99/50-778_Ellence_biopharmr.pdf</ref_url></metabolism></metabolism_refs><metabolite_chembl_id>CHEMBL3507701</metabolite_chembl_id><metabolite_name>Metabolite M4</metabolite_name><organism>Homo sapiens</organism><pathway_id>1</pathway_id><pathway_key>Fig. 2, p.19</pathway_key><substrate_chembl_id>CHEMBL1639</substrate_chembl_id><substrate_name>Aliskiren, SPP100</substrate_name><target_chembl_id/><tax_id>9606</tax_id></metabolism><metabolism><drug_chembl_id>CHEMBL1639</drug_chembl_id><enzyme_name/><met_comment>Species: Figure legend also mentions Rattus norvegicus.</met_comment><met_conversion/><met_id>130</met_id><metabolism_refs><metabolism><ref_id>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_PharmR_P2.pdf</ref_id><ref_type>OTHER</ref_type><ref_url>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_PharmR_P2.pdf</ref_url></metabolism></metabolism_refs><metabolite_chembl_id>CHEMBL3507701</metabolite_chembl_id><metabolite_name>Metabolite M4</metabolite_name><organism>Mus musculus</organism><pathway_id>1</pathway_id><pathway_key>Fig. 2.1.1.1, p.35</pathway_key><substrate_chembl_id>CHEMBL3507700</substrate_chembl_id><substrate_name>Metabolite M3</substrate_name><target_chembl_id/><tax_id>10090</tax_id></metabolism><metabolism><drug_chembl_id>CHEMBL1639</drug_chembl_id><enzyme_name/><met_comment>Species: Figure legend also mentions Rattus norvegicus.</met_comment><met_conversion/><met_id>131</met_id><metabolism_refs><metabolism><ref_id>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_PharmR_P2.pdf</ref_id><ref_type>OTHER</ref_type><ref_url>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_PharmR_P2.pdf</ref_url></metabolism></metabolism_refs><metabolite_chembl_id>CHEMBL3507701</metabolite_chembl_id><metabolite_name>Metabolite M4</metabolite_name><organism>Mus musculus</organism><pathway_id>1</pathway_id><pathway_key>Fig. 2.1.1.1, p.35</pathway_key><substrate_chembl_id>CHEMBL3507697</substrate_chembl_id><substrate_name>Metabolite M2</substrate_name><target_chembl_id/><tax_id>10090</tax_id></metabolism><metabolism><drug_chembl_id>CHEMBL1639</drug_chembl_id><enzyme_name/><met_comment>Species: Figure legend also mentions Rattus norvegicus.</met_comment><met_conversion>C-oxidation</met_conversion><met_id>132</met_id><metabolism_refs><metabolism><ref_id>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_PharmR_P2.pdf</ref_id><ref_type>OTHER</ref_type><ref_url>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_PharmR_P2.pdf</ref_url></metabolism></metabolism_refs><metabolite_chembl_id>CHEMBL3507697</metabolite_chembl_id><metabolite_name>Metabolite M2</metabolite_name><organism>Mus musculus</organism><pathway_id>1</pathway_id><pathway_key>Fig. 2.1.1.1, p.35</pathway_key><substrate_chembl_id>CHEMBL3507700</substrate_chembl_id><substrate_name>Metabolite M3</substrate_name><target_chembl_id/><tax_id>10090</tax_id></metabolism><metabolism><drug_chembl_id>CHEMBL1639</drug_chembl_id><enzyme_name/><met_comment/><met_conversion>Oxidation</met_conversion><met_id>133</met_id><metabolism_refs><metabolism><ref_id>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_PharmR_P2.pdf</ref_id><ref_type>OTHER</ref_type><ref_url>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_PharmR_P2.pdf</ref_url></metabolism></metabolism_refs><metabolite_chembl_id>CHEMBL3507697</metabolite_chembl_id><metabolite_name>Metabolite M2</metabolite_name><organism>Callithrix jacchus</organism><pathway_id>2</pathway_id><pathway_key>Fig. 2.1.4.1, p.46</pathway_key><substrate_chembl_id>CHEMBL3507700</substrate_chembl_id><substrate_name>Metabolite M3</substrate_name><target_chembl_id/><tax_id>9483</tax_id></metabolism><metabolism><drug_chembl_id>CHEMBL1639</drug_chembl_id><enzyme_name/><met_comment/><met_conversion>Oxidation</met_conversion><met_id>134</met_id><metabolism_refs><metabolism><ref_id>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_ClinPharmR_P2.pdf</ref_id><ref_type>OTHER</ref_type><ref_url>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_ClinPharmR_P2.pdf</ref_url></metabolism><metabolism><ref_id>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_ClinPharmR_P3.pdf</ref_id><ref_type>OTHER</ref_type><ref_url>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_ClinPharmR_P3.pdf</ref_url></metabolism></metabolism_refs><metabolite_chembl_id>CHEMBL3507697</metabolite_chembl_id><metabolite_name>Metabolite M2</metabolite_name><organism>Homo sapiens</organism><pathway_id>3</pathway_id><pathway_key>Fig. 9, p164/165</pathway_key><substrate_chembl_id>CHEMBL3507700</substrate_chembl_id><substrate_name>Metabolite M3</substrate_name><target_chembl_id/><tax_id>9606</tax_id></metabolism><metabolism><drug_chembl_id>CHEMBL1639</drug_chembl_id><enzyme_name/><met_comment>Species: Figure legend also mentions Rattus norvegicus.</met_comment><met_conversion/><met_id>135</met_id><metabolism_refs><metabolism><ref_id>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_PharmR_P2.pdf</ref_id><ref_type>OTHER</ref_type><ref_url>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_PharmR_P2.pdf</ref_url></metabolism></metabolism_refs><metabolite_chembl_id>CHEMBL3507697</metabolite_chembl_id><metabolite_name>Metabolite M2</metabolite_name><organism>Mus musculus</organism><pathway_id>1</pathway_id><pathway_key>Fig. 2.1.1.1, p.35</pathway_key><substrate_chembl_id>CHEMBL1639</substrate_chembl_id><substrate_name>Aliskiren, SPP100</substrate_name><target_chembl_id/><tax_id>10090</tax_id></metabolism><metabolism><drug_chembl_id>CHEMBL1639</drug_chembl_id><enzyme_name/><met_comment>Species: Figure legend also mentions Rattus norvegicus.</met_comment><met_conversion>Glucuronidation</met_conversion><met_id>136</met_id><metabolism_refs><metabolism><ref_id>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_PharmR_P2.pdf</ref_id><ref_type>OTHER</ref_type><ref_url>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_PharmR_P2.pdf</ref_url></metabolism></metabolism_refs><metabolite_chembl_id>CHEMBL3507696</metabolite_chembl_id><metabolite_name>Metabolite M5</metabolite_name><organism>Mus musculus</organism><pathway_id>1</pathway_id><pathway_key>Fig. 2.1.1.1, p.35</pathway_key><substrate_chembl_id>CHEMBL3507699</substrate_chembl_id><substrate_name>Metabolite M1</substrate_name><target_chembl_id/><tax_id>10090</tax_id></metabolism><metabolism><drug_chembl_id>CHEMBL1639</drug_chembl_id><enzyme_name/><met_comment>Species: Figure legend also mentions Rattus norvegicus.</met_comment><met_conversion>Glucuronidation</met_conversion><met_id>137</met_id><metabolism_refs><metabolism><ref_id>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_PharmR_P2.pdf</ref_id><ref_type>OTHER</ref_type><ref_url>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_PharmR_P2.pdf</ref_url></metabolism></metabolism_refs><metabolite_chembl_id>CHEMBL3507695</metabolite_chembl_id><metabolite_name>Metabolite M6</metabolite_name><organism>Mus musculus</organism><pathway_id>1</pathway_id><pathway_key>Fig. 2.1.1.1, p.35</pathway_key><substrate_chembl_id>CHEMBL3507701</substrate_chembl_id><substrate_name>Metabolite M4</substrate_name><target_chembl_id/><tax_id>10090</tax_id></metabolism><metabolism><drug_chembl_id>CHEMBL1639</drug_chembl_id><enzyme_name/><met_comment/><met_conversion>O-glucuronidation</met_conversion><met_id>138</met_id><metabolism_refs><metabolism><ref_id>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_ClinPharmR_P2.pdf</ref_id><ref_type>OTHER</ref_type><ref_url>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_ClinPharmR_P2.pdf</ref_url></metabolism><metabolism><ref_id>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_ClinPharmR_P3.pdf</ref_id><ref_type>OTHER</ref_type><ref_url>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_ClinPharmR_P3.pdf</ref_url></metabolism></metabolism_refs><metabolite_chembl_id>CHEMBL3507695</metabolite_chembl_id><metabolite_name>Metabolite M6</metabolite_name><organism>Homo sapiens</organism><pathway_id>3</pathway_id><pathway_key>Fig. 9, p164/165</pathway_key><substrate_chembl_id>CHEMBL3507701</substrate_chembl_id><substrate_name>Metabolite M4</substrate_name><target_chembl_id/><tax_id>9606</tax_id></metabolism><metabolism><drug_chembl_id>CHEMBL1639</drug_chembl_id><enzyme_name/><met_comment/><met_conversion/><met_id>139</met_id><metabolism_refs><metabolism><ref_id>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_ClinPharmR_P2.pdf</ref_id><ref_type>OTHER</ref_type><ref_url>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_ClinPharmR_P2.pdf</ref_url></metabolism><metabolism><ref_id>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_ClinPharmR_P3.pdf</ref_id><ref_type>OTHER</ref_type><ref_url>http://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/021985s000_ClinPharmR_P3.pdf</ref_url></metabolism></metabolism_refs><metabolite_chembl_id>CHEMBL3507701</metabolite_chembl_id><metabolite_name>Metabolite M4</metabolite_name><organism>Homo sapiens</organism><pathway_id>3</pathway_id><pathway_key>Fig. 9, p164/165</pathway_key><substrate_chembl_id>CHEMBL3507697</substrate_chembl_id><substrate_name>Metabolite M2</substrate_name><target_chembl_id/><tax_id>9606</tax_id></metabolism></metabolisms><page_meta><limit>20</limit><next>/chembl/api/data/metabolism?limit=20&amp;offset=20</next><offset/><previous/><total_count>2147</total_count></page_meta></response>