{"abstract": "Human carbonic anhydrases IX and XII are upregulated in many tumors and form a novel target for new generation anticancer drugs. Here we report the synthesis of novel 2-indolinone derivatives with the sulfonamide group as a zinc binding moiety. Enzyme inhibition assays confirmed that the compounds showed selectivity against hCA IX and XII over the widely distributed off-targets hCA I and II. Molecular modelling studies were performed to suggest modes of binding for these compounds.", "authors": "Karalı N, Akdemir A, Göktaş F, Eraslan Elma P, Angeli A, Kızılırmak M, Supuran CT.", "chembl_release": {"chembl_release": "CHEMBL_25", "creation_date": "2018-12-10"}, "contact": null, "doc_type": "PUBLICATION", "document_chembl_id": "CHEMBL4033724", "doi": "10.1016/j.bmc.2017.05.029", "doi_chembl": null, "first_page": "3714", "issue": "14", "journal": "Bioorg Med Chem", "journal_full_title": "Bioorganic & medicinal chemistry.", "last_page": "3718", "patent_id": null, "pubmed_id": 28545816, "src_id": 1, "title": "Novel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases.", "volume": "25", "year": 2017}