{"documents": [{"abstract": "New screening and selection cascade for hit generation of compounds active against the blood stage of Plasmodium falciparum. Screen of the Hit Generation library 1 (HGL1), a library of 141,786 novel compounds, using a robust high throughput screening cascade containing orthogonal\nefficacy and cytotoxicity assays, including a newly developed and validated\nnanoluciferase-based assay.", "authors": "Dechering K; Duffey M", "chembl_release": {"chembl_release": "CHEMBL_31", "creation_date": "2022-07-12"}, "contact": null, "doc_type": "DATASET", "document_chembl_id": "CHEMBL4888484", "doi": "10.6019/CHEMBL4888484", "doi_chembl": null, "first_page": null, "issue": null, "journal": null, "journal_full_title": null, "last_page": null, "patent_id": null, "pubmed_id": null, "src_id": 60, "title": "Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum ,using a nano luciferase reporter read-out", "volume": null, "year": 2022}], "page_meta": {"limit": 20, "next": null, "offset": 0, "previous": null, "total_count": 1}}