CLD0CHEMBL615120Bos taurusMembrane9913StriatumBBindingBAO_0000249cell membrane formatMultiple homologous protein targets may be assigned4Binding affinity against A2 adenosine receptor in bovine striatal membranes using [3H]CGS-21680CHEMBL1149169Homologous protein target assignedH1CHEMBL2094257CHEMBL3638255CLD0CHEMBL615159Rattus norvegicus10116TestisBBindingBAO_0000221tissue-based formatDirect single protein target assigned9Inhibition of 17-alpha-hydroxylase/17,20 lyase from rat testes microsomal preparationCHEMBL1124902Direct protein target assignedD1CHEMBL4430CHEMBL3638183CLD0CHEMBL615172Rattus norvegicus10116TestisBBindingBAO_0000221tissue-based formatDirect single protein target assigned9Inhibition of 17-alpha-hydroxylase/17,20 lyase from rat testes microsomal preparationCHEMBL1124902Direct protein target assignedD1CHEMBL4430CHEMBL3638183CLD0CHEMBL615207Sus scrofaMicrosome9823LiverBBindingBAO_0000251microsome formatHomologous single protein target assigned8Compound was evaluated for the inhibition of microsomal 2,3-oxidosqualene-lanosterol cyclase in pig liver microsomesCHEMBL1125522Homologous protein target assignedH1CHEMBL3262CHEMBL3559723CLD0CHEMBL615210Rattus norvegicusMicrosome10116LiverBBindingBAO_0000251microsome formatDirect single protein target assigned9Compound was evaluated for the inhibition of microsomal 2,3-oxidosqualene cyclase in rat liver microsomesCHEMBL1125522Direct protein target assignedD1CHEMBL3262CHEMBL3559723CLD0CHEMBL615211Rattus norvegicusMicrosome10116LiverBBindingBAO_0000251microsome formatDirect single protein target assigned9Compound was evaluated for the inhibition of microsomal 2,3-oxidosqualene-lanosterol cyclase in rat liver microsomesCHEMBL1125522Direct protein target assignedD1CHEMBL3262CHEMBL3559723CLD0CHEMBL615212Rattus norvegicusMicrosome10116LiverBBindingBAO_0000251microsome formatDirect single protein target assigned9Compound was evaluated for inhibitory activity against 2,3-oxidosqualene-lanosterol cyclase in rat liver microsomesCHEMBL1126228Direct protein target assignedD1CHEMBL3262CHEMBL3559723CLD0CHEMBL615353Homo sapiens9606BrainBBindingBAO_0000220subcellular formatMultiple direct protein targets may be assigned5Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brainCHEMBL1128409Direct protein target assignedD1CHEMBL3831201CHEMBL3638188CLD0CHEMBL615361Rattus norvegicus1IntravenousROUTEIntravenousROUTE1==DOSEmg.kg-10.002DOSEmg/kg0.00210116HeartFFunctionalBAO_0000218organism-based formatDefault value - Target unknown or has yet to be assignedChange in heart rate was expressed in percent at at a dose 0.002 mg/kg iv in anesthetized ratCHEMBL1125861Default value - Target has yet to be curatedU1CHEMBL612545CHEMBL3638187CLD0CHEMBL615230Rattus norvegicus10116Adrenal glandBBindingBAO_0000221tissue-based formatDirect single protein target assigned9Inhibition of 11 beta-hydroxylase from rat adrenal glandCHEMBL1123410Direct protein target assignedD1CHEMBL4970CHEMBL3638251CLD0CHEMBL615252PlasmaBBindingBAO_0000366cell-free formatHomologous single protein target assigned8Inhibitory activity against 12-lipoxygenase in rat platelet rich plasmaCHEMBL1125679Homologous protein target assignedH1CHEMBL2741CHEMBL3559721CLD0CHEMBL615707Cavia porcellus10141IleumFFunctionalBAO_0000221tissue-based formatDirect single protein target assigned9Relative ability to increase cholinergically mediated contractions in isolated ileum of guinea pigCHEMBL1126614Direct protein target assignedD1CHEMBL5017CHEMBL3638244CLD0CHEMBL881818Frontal cortexBBindingBAO_0000221tissue-based formatHomologous single protein target assigned8Inhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assayCHEMBL1133697Homologous protein target assignedH1CHEMBL3459CHEMBL3638220CLD0CHEMBL615722Cerebral cortexBBindingBAO_0000221tissue-based formatMultiple homologous protein targets may be assigned4Displacement of binding of [3H]-5-HT to 5-hydroxytryptamine 1 receptor in rat cerebral cortexCHEMBL1127026Homologous protein target assignedH1CHEMBL2095159CHEMBL3559724CLD0CHEMBL615724HippocampusBBindingBAO_0000221tissue-based formatHomologous single protein target assigned8In vitro inhibition of [3H]5-HT (2 nM) binding to 5-hydroxytryptamine 1A receptor from bovine hippocampusCHEMBL1124409Homologous protein target assignedH1CHEMBL214CHEMBL3638273CLD0CHEMBL615725HippocampusBBindingBAO_0000221tissue-based formatHomologous single protein target assigned8In vitro inhibition of [3H]DPAT (1 nM) binding to 5-HT1A receptor from bovine hippocampusCHEMBL1124409Homologous protein target assignedH1CHEMBL214CHEMBL3638273CLD0CHEMBL615726HippocampusBBindingBAO_0000221tissue-based formatHomologous single protein target assigned8In vitro inhibition of [3H]DPAT (1 nM) binding to 5-hydroxytryptamine 1A receptor from bovine hippocampusCHEMBL1124409Homologous protein target assignedH1CHEMBL214CHEMBL3638273CLD0CHEMBL615731TailFFunctionalBAO_0000221tissue-based formatHomologous single protein target assigned8Intrinsic activity towards 5-HT2A receptor of rat tail arteryCHEMBL1132168Homologous protein target assignedH1CHEMBL322CHEMBL3833541CLD0CHEMBL615732TailFFunctionalBAO_0000221tissue-based formatHomologous single protein target assigned8Relative potency towards 5-HT2A receptor of rat tail arteryCHEMBL1132168Homologous protein target assignedH1CHEMBL322CHEMBL3833541CLD0CHEMBL615733ArteryFFunctionalBAO_0000221tissue-based formatHomologous single protein target assigned8Blocking 5-HT2A receptor-mediated contractions of rat tail arteryCHEMBL1132168Homologous protein target assignedH1CHEMBL322CHEMBL363821620/chembl/api/data/assay?limit=20&offset=20&assay_tissue__isnull=false211996