111169CHEMBL820995Affinity for HERG voltage-gated potassium channel subunit Kv11.1BBAO_0000179BAO_0000357single protein formatCN1CCN(C(=O)c2ccc3[nH]c(-c4cc5ccccc5nc4O)cc3c2)CC1CHEMBL1137936Bioorg Med Chem Lett2004CHEMBL324489CHEMBL324489http://www.openphacts.org/units/Nanomolar224670=1=IPnM10800.0CHEMBL240Homo sapiensVoltage-gated inwardly rectifying potassium channel KCNH29606IPnMUO_000006510800.0117680CHEMBL820995Affinity for HERG voltage-gated potassium channel subunit Kv11.1BBAO_0000179BAO_0000357single protein formatO=S(=O)(NC1CCNC1)c1ccc2[nH]c(-c3cc4ccccc4nc3O)cc2c1CHEMBL1137936Bioorg Med Chem Lett2004CHEMBL420528CHEMBL420528http://www.openphacts.org/units/Nanomolar224680=1=IPnM2835.0CHEMBL240Homo sapiensVoltage-gated inwardly rectifying potassium channel KCNH29606IPnMUO_00000652835.0120052CHEMBL820995Affinity for HERG voltage-gated potassium channel subunit Kv11.1BBAO_0000179BAO_0000357single protein formatO=C(O)C1CCN(CCCOc2ccc3[nH]c(-c4cc5ccccc5nc4O)cc3c2)CC1CHEMBL1137936Bioorg Med Chem Lett2004CHEMBL118748CHEMBL118748http://www.openphacts.org/units/Nanomolar224668=1=IPnM3050.0CHEMBL240Homo sapiensVoltage-gated inwardly rectifying potassium channel KCNH29606IPnMUO_00000653050.0120053CHEMBL820994Effect on prolongation of the heart rate-corrected QT intervalFBAO_0000179BAO_0000221tissue-based formatO=C(O)C1CCN(CCCOc2ccc3[nH]c(-c4cc5ccccc5nc4O)cc3c2)CC1CHEMBL1137936Bioorg Med Chem Lett2004CHEMBL118748CHEMBL118748http://www.openphacts.org/units/Nanomolar224668=1=EC10nM5200.0CHEMBL240Homo sapiensVoltage-gated inwardly rectifying potassium channel KCNH29606EC10nMUO_00000655200.0120059CHEMBL820995Affinity for HERG voltage-gated potassium channel subunit Kv11.1BBAO_0000179BAO_0000357single protein formatNC1CCN(C(=O)c2ccc3[nH]c(-c4cc5ccccc5nc4O)cc3c2)C1CHEMBL1137936Bioorg Med Chem Lett2004CHEMBL117052CHEMBL117052http://www.openphacts.org/units/Nanomolar224675>1>IPnM10000.0CHEMBL240Homo sapiensVoltage-gated inwardly rectifying potassium channel KCNH29606IPnMUO_000006510000.0121343CHEMBL820995Affinity for HERG voltage-gated potassium channel subunit Kv11.1BBAO_0000179BAO_0000357single protein formatO=C(c1ccc2[nH]c(-c3cc4ccccc4nc3O)cc2c1)N1CCNCC1CHEMBL1137936Bioorg Med Chem Lett2004CHEMBL119552CHEMBL119552http://www.openphacts.org/units/Nanomolar224671>1>IPnM10000.0CHEMBL240Homo sapiensVoltage-gated inwardly rectifying potassium channel KCNH29606IPnMUO_000006510000.0122563CHEMBL820995Affinity for HERG voltage-gated potassium channel subunit Kv11.1BBAO_0000179BAO_0000357single protein formatO=S(=O)(c1ccc2[nH]c(-c3cc4ccccc4nc3O)cc2c1)N1CCNCC1CHEMBL1137936Bioorg Med Chem Lett2004CHEMBL118832CHEMBL118832http://www.openphacts.org/units/Nanomolar224678=1=IPnM2450.0CHEMBL240Homo sapiensVoltage-gated inwardly rectifying potassium channel KCNH29606IPnMUO_00000652450.0125126CHEMBL820995Affinity for HERG voltage-gated potassium channel subunit Kv11.1BBAO_0000179BAO_0000357single protein formatNC1CCN(S(=O)(=O)c2ccc3[nH]c(-c4cc5ccccc5nc4O)cc3c2)C1CHEMBL1137936Bioorg Med Chem Lett2004CHEMBL323838CHEMBL323838http://www.openphacts.org/units/Nanomolar224679=1=IPnM2650.0CHEMBL240Homo sapiensVoltage-gated inwardly rectifying potassium channel KCNH29606IPnMUO_00000652650.0126541CHEMBL820995Affinity for HERG voltage-gated potassium channel subunit Kv11.1BBAO_0000179BAO_0000357single protein formatOc1nc2ccccc2cc1-c1cc2cc(OCCN3CCCCC3)ccc2[nH]1CHEMBL1137936Bioorg Med Chem Lett2004CHEMBL333297CHEMBL333297http://www.openphacts.org/units/Nanomolar224669=1=IPnM980.0CHEMBL240Homo sapiensVoltage-gated inwardly rectifying potassium channel KCNH29606IPnMUO_0000065980.0126542CHEMBL820994Effect on prolongation of the heart rate-corrected QT intervalFBAO_0000179BAO_0000221tissue-based formatOc1nc2ccccc2cc1-c1cc2cc(OCCN3CCCCC3)ccc2[nH]1CHEMBL1137936Bioorg Med Chem Lett2004CHEMBL333297CHEMBL333297http://www.openphacts.org/units/Nanomolar224669=1=EC10nM640.0CHEMBL240Homo sapiensVoltage-gated inwardly rectifying potassium channel KCNH29606EC10nMUO_0000065640.0128966CHEMBL820995Affinity for HERG voltage-gated potassium channel subunit Kv11.1BBAO_0000179BAO_0000357single protein formatCOCCN(C)CCOc1ccc2[nH]c(-c3cc4ccccc4nc3O)cc2c1CHEMBL1137936Bioorg Med Chem Lett2004CHEMBL118569CHEMBL118569http://www.openphacts.org/units/Nanomolar224666=1=IPnM1950.0CHEMBL240Homo sapiensVoltage-gated inwardly rectifying potassium channel KCNH29606IPnMUO_00000651950.0128967CHEMBL820994Effect on prolongation of the heart rate-corrected QT intervalFBAO_0000179BAO_0000221tissue-based formatCOCCN(C)CCOc1ccc2[nH]c(-c3cc4ccccc4nc3O)cc2c1CHEMBL1137936Bioorg Med Chem Lett2004CHEMBL118569CHEMBL118569http://www.openphacts.org/units/Nanomolar224666=1=EC10nM1900.0CHEMBL240Homo sapiensVoltage-gated inwardly rectifying potassium channel KCNH29606EC10nMUO_00000651900.0135305CHEMBL820995Affinity for HERG voltage-gated potassium channel subunit Kv11.1BBAO_0000179BAO_0000357single protein formatO=C(NC1CCNC1)c1ccc2[nH]c(-c3cc4ccccc4nc3O)cc2c1CHEMBL1137936Bioorg Med Chem Lett2004CHEMBL325003CHEMBL325003http://www.openphacts.org/units/Nanomolar224676=1=IPnM13700.0CHEMBL240Homo sapiensVoltage-gated inwardly rectifying potassium channel KCNH29606IPnMUO_000006513700.0136548CHEMBL820995Affinity for HERG voltage-gated potassium channel subunit Kv11.1BBAO_0000179BAO_0000357single protein formatCC(=O)N1CCN(CCOc2ccc3[nH]c(-c4cc5ccccc5nc4O)cc3c2)CC1CHEMBL1137936Bioorg Med Chem Lett2004CHEMBL119276CHEMBL119276http://www.openphacts.org/units/Nanomolar224667=1=IPnM520.0CHEMBL240Homo sapiensVoltage-gated inwardly rectifying potassium channel KCNH29606IPnMUO_0000065520.0141157CHEMBL820995Affinity for HERG voltage-gated potassium channel subunit Kv11.1BBAO_0000179BAO_0000357single protein formatCN1CCN(S(=O)(=O)c2ccc3[nH]c(-c4cc5ccccc5nc4O)cc3c2)CC1CHEMBL1137936Bioorg Med Chem Lett2004CHEMBL117983CHEMBL117983http://www.openphacts.org/units/Nanomolar224677=1=IPnM3440.0CHEMBL240Homo sapiensVoltage-gated inwardly rectifying potassium channel KCNH29606IPnMUO_00000653440.0224312CHEMBL824627Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikr channel)BBAO_0000192BAO_0000219cell-based formatCC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(C(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1CHEMBL1135170Bioorg Med Chem Lett200210.390.20-0.8916.64CHEMBL296979CHEMBL2969795.92http://www.openphacts.org/units/Nanomolar82904=11=KinM1200.0CHEMBL240Homo sapiensVoltage-gated inwardly rectifying potassium channel KCNH29606KinMUO_00000651200.0225577CHEMBL824627Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikr channel)BBAO_0000192BAO_0000219cell-based formatCC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCCO3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1CHEMBL1135170Bioorg Med Chem Lett200210.530.20-1.2914.76CHEMBL3085129CHEMBL30851296.14http://www.openphacts.org/units/Nanomolar82913=11=KinM730.0CHEMBL240Homo sapiensVoltage-gated inwardly rectifying potassium channel KCNH29606KinMUO_0000065730.0228175CHEMBL824627Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikr channel)BBAO_0000192BAO_0000219cell-based formatCC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1CHEMBL1135170Bioorg Med Chem Lett200211.870.23-1.4322.78CHEMBL296397CHEMBL2963977.37http://www.openphacts.org/units/Nanomolar82907=11=KinM43.0CHEMBL240Homo sapiensVoltage-gated inwardly rectifying potassium channel KCNH29606KinMUO_000006543.0232020CHEMBL824627Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikr channel)BBAO_0000192BAO_0000219cell-based formatCC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N2CCCCC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1CHEMBL1135170Bioorg Med Chem Lett200211.240.22-1.3518.31CHEMBL3085124CHEMBL30851245.92http://www.openphacts.org/units/Nanomolar82903=11=KinM1200.0CHEMBL240Homo sapiensVoltage-gated inwardly rectifying potassium channel KCNH29606KinMUO_00000651200.0232022CHEMBL824627Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikr channel)BBAO_0000192BAO_0000219cell-based formatCC1CCN([C@H]2CC[C@](NC(=O)C(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1CHEMBL1135170Bioorg Med Chem Lett200211.720.23-1.1719.60CHEMBL3085128CHEMBL30851286.34http://www.openphacts.org/units/Nanomolar82902=11=KinM460.0CHEMBL240Homo sapiensVoltage-gated inwardly rectifying potassium channel KCNH29606KinMUO_0000065460.020/chembl/api/data/activity?limit=20&offset=20&target_chembl_id=CHEMBL24041078