Not Determined31883CHEMBL752464Antimycobacterial activity against Mycobacterium tuberculosis strain H37Rv; NT = not testedFBAO_0000201BAO_0000218organism-based formatCc1cn(C2C=CC(COC(=O)CN3CCNCC3)O2)c(=O)[nH]c1=OCHEMBL1138695Bioorg Med Chem Lett2004CHEMBL174698CHEMBL174698http://qudt.org/vocab/unit#Percent3505891Inhibition%CHEMBL360Mycobacterium tuberculosisMycobacterium tuberculosis1773InhibitionUO_000018731884CHEMBL618375In vitro hydrolysis in human plasmaABAO_0002115BAO_0000366cell-free formatCc1cn(C2C=CC(COC(=O)CN3CCNCC3)O2)c(=O)[nH]c1=OCHEMBL1138695Bioorg Med Chem Lett2004CHEMBL174698CHEMBL174698http://qudt.org/vocab/unit#Hour350589=11=T1/2hr0.3333CHEMBL612558ADMETT1/2minUO_000003220.031885CHEMBL824039Inhibition of ZipA FtsZ binding at 1 mM using an optical biosensor systemBBAO_0000201BAO_0000019assay formatNCCCn1c2c(c3ccccc31)C(=O)CN1CCCCC21CHEMBL1147622Bioorg Med Chem Lett2004CHEMBL416206CHEMBL416206http://qudt.org/vocab/unit#Percent49353=11=Inhibition%47.0CHEMBL612545UncheckedInhibition%UO_000018747.031886CHEMBL858517Antibacterial activity against Gram-positive, Gram-negative bacteria and Escherichia coliFBAO_0002146BAO_0000019assay formatNCCCn1c2c(c3ccccc31)C(=O)CN1CCCCC21CHEMBL1147622Bioorg Med Chem Lett2004CHEMBL416206CHEMBL416206http://www.openphacts.org/units/Nanomolar49353>=11>=MICnM200000.0CHEMBL3879801NON-PROTEIN TARGETMICuMUO_0000065200.031887CHEMBL824039Inhibition of ZipA FtsZ binding at 1 mM using an optical biosensor systemBBAO_0000201BAO_0000019assay formatO=C(NCCCn1c2c(c3ccccc31)C(=O)CN1CCCCC21)c1ccco1CHEMBL1147622Bioorg Med Chem Lett2004CHEMBL33450CHEMBL33450http://qudt.org/vocab/unit#Percent49354=11=Inhibition%38.0CHEMBL612545UncheckedInhibition%UO_000018738.031888CHEMBL858517Antibacterial activity against Gram-positive, Gram-negative bacteria and Escherichia coliFBAO_0002146BAO_0000019assay formatO=C(NCCCn1c2c(c3ccccc31)C(=O)CN1CCCCC21)c1ccco1CHEMBL1147622Bioorg Med Chem Lett2004CHEMBL33450CHEMBL33450http://www.openphacts.org/units/Nanomolar49354>=11>=MICnM200000.0CHEMBL3879801NON-PROTEIN TARGETMICuMUO_0000065200.031889CHEMBL873200Inhibitory activity against human carbonic anhydrase I (hCA I) by using esterase assay methodBBAO_0000192BAO_0000357single protein formatNc1ccc(S(N)(=O)=O)cc1ICHEMBL1146805Bioorg Med Chem Lett200417.520.594.706.06CHEMBL268177CHEMBL2681775.221http://www.openphacts.org/units/Nanomolar235484=11=KinM6000.0CHEMBL261Homo sapiensCarbonic anhydrase 19606KinMUO_00000656000.031890CHEMBL657848Inhibitory activity against human carbonic anhydrase II (hCA II) by using esterase assay methodBBAO_0000192BAO_0000357single protein formatNc1ccc(S(N)(=O)=O)cc1ICHEMBL1146805Bioorg Med Chem Lett200424.000.816.638.30CHEMBL268177CHEMBL2681777.161http://www.openphacts.org/units/Nanomolar235484=11=KinM70.0CHEMBL205Homo sapiensCarbonic anhydrase 29606KinMUO_000006570.031891CHEMBL657970Inhibitory activity against human carbonic anhydrase IX (hCA IX) by using CO2 hydrase assay methodBBAO_0000192BAO_0000357single protein formatNc1ccc(S(N)(=O)=O)cc1ICHEMBL1146805Bioorg Med Chem Lett200421.960.746.037.59CHEMBL268177CHEMBL2681776.541http://www.openphacts.org/units/Nanomolar235484=11=KinM285.0CHEMBL3594Homo sapiensCarbonic anhydrase 99606KinMUO_0000065285.031892CHEMBL657976Inhibitory activity against murine carbonic anhydrase XIII (mCA XIII) by using CO2 hydrase assay methodBBAO_0000192BAO_0000357single protein formatNc1ccc(S(N)(=O)=O)cc1ICHEMBL1146805Bioorg Med Chem Lett200424.490.836.788.47CHEMBL268177CHEMBL2681777.30http://www.openphacts.org/units/Nanomolar235484=11=KinM50.0CHEMBL2186Mus musculusCarbonic anhydrase 1310090KinMUO_000006550.031893CHEMBL873200Inhibitory activity against human carbonic anhydrase I (hCA I) by using esterase assay methodBBAO_0000192BAO_0000357single protein formatNc1ccc(S(=O)(=O)Nc2nnc(S(N)(=O)=O)s2)cc1CHEMBL1146805Bioorg Med Chem Lett200424.510.568.655.20CHEMBL268439CHEMBL2684398.221http://www.openphacts.org/units/Nanomolar235480=11=KinM6.0CHEMBL261Homo sapiensCarbonic anhydrase 19606KinMUO_00000656.031894CHEMBL657848Inhibitory activity against human carbonic anhydrase II (hCA II) by using esterase assay methodBBAO_0000192BAO_0000357single protein formatNc1ccc(S(=O)(=O)Nc2nnc(S(N)(=O)=O)s2)cc1CHEMBL1146805Bioorg Med Chem Lett200425.940.599.135.50CHEMBL268439CHEMBL2684398.701http://www.openphacts.org/units/Nanomolar235480=11=KinM2.0CHEMBL205Homo sapiensCarbonic anhydrase 29606KinMUO_00000652.031895CHEMBL657970Inhibitory activity against human carbonic anhydrase IX (hCA IX) by using CO2 hydrase assay methodBBAO_0000192BAO_0000357single protein formatNc1ccc(S(=O)(=O)Nc2nnc(S(N)(=O)=O)s2)cc1CHEMBL1146805Bioorg Med Chem Lett200422.120.517.854.69CHEMBL268439CHEMBL2684397.421http://www.openphacts.org/units/Nanomolar235480=11=KinM38.0CHEMBL3594Homo sapiensCarbonic anhydrase 99606KinMUO_000006538.031896CHEMBL657976Inhibitory activity against murine carbonic anhydrase XIII (mCA XIII) by using CO2 hydrase assay methodBBAO_0000192BAO_0000357single protein formatNc1ccc(S(=O)(=O)Nc2nnc(S(N)(=O)=O)s2)cc1CHEMBL1146805Bioorg Med Chem Lett200425.940.599.135.50CHEMBL268439CHEMBL2684398.70http://www.openphacts.org/units/Nanomolar235480=11=KinM2.0CHEMBL2186Mus musculusCarbonic anhydrase 1310090KinMUO_00000652.031897CHEMBL640247Binding affinity against adenosine A1 receptor using [3H]CPX in guinea pig DDT membrane; 913+/-517BBAO_0000179BAO_0000019assay formatO[C@@H]1[C@@H](CSc2ncccn2)OC(n2cnc3c(NC4CCOC4)ncnc32)[C@@H]1OCHEMBL1137935Bioorg Med Chem Lett2004CHEMBL608018CHEMBL608018http://www.openphacts.org/units/Nanomolar237264=1=Ki lownM913.0CHEMBL2304404Cavia porcellusAdenosine receptor A110141Ki lownMUO_0000065913.031898CHEMBL677060Binding affinity against GTPgammaS receptor using [35S]GTP-gamma-S, radioligand in guinea pig.FBAO_0000179BAO_0000019assay formatO[C@@H]1[C@@H](CSc2ncccn2)OC(n2cnc3c(NC4CCOC4)ncnc32)[C@@H]1OCHEMBL1137935Bioorg Med Chem Lett2004CHEMBL608018CHEMBL608018http://qudt.org/vocab/unit#Percent237264=1=CPA%89.0CHEMBL2304404Cavia porcellusAdenosine receptor A110141CPA%UO_000018789.031899CHEMBL645219Binding affinity against adenosine A1 receptor using [3H]CCPA in guinea pig DDT membrane; 102+/-45BBAO_0000179BAO_0000019assay formatO[C@@H]1[C@@H](CSc2c(Cl)cccc2Cl)OC(n2cnc3c(NC4CCOC4)ncnc32)[C@@H]1OCHEMBL1137935Bioorg Med Chem Lett2004CHEMBL609538CHEMBL609538http://www.openphacts.org/units/Nanomolar237241=1=Ki highnM102.0CHEMBL2304404Cavia porcellusAdenosine receptor A110141Ki highnMUO_0000065102.031900CHEMBL640243Binding affinity against adenosine A1 receptor using [3H]CPX in guinea pig DDT membrane; 614+/-78BBAO_0000179BAO_0000019assay formatO[C@@H]1[C@@H](CSc2c(Cl)cccc2Cl)OC(n2cnc3c(NC4CCOC4)ncnc32)[C@@H]1OCHEMBL1137935Bioorg Med Chem Lett2004CHEMBL609538CHEMBL609538http://www.openphacts.org/units/Nanomolar237241=1=Ki lownM614.0CHEMBL2304404Cavia porcellusAdenosine receptor A110141Ki lownMUO_0000065614.031901CHEMBL677060Binding affinity against GTPgammaS receptor using [35S]GTP-gamma-S, radioligand in guinea pig.FBAO_0000179BAO_0000019assay formatO[C@@H]1[C@@H](CSc2c(Cl)cccc2Cl)OC(n2cnc3c(NC4CCOC4)ncnc32)[C@@H]1OCHEMBL1137935Bioorg Med Chem Lett2004CHEMBL609538CHEMBL609538http://qudt.org/vocab/unit#Percent237241=1=CPA%89.0CHEMBL2304404Cavia porcellusAdenosine receptor A110141CPA%UO_000018789.031902CHEMBL761156In vitro antimalarial activity against Plasmodium falciparum FCR3FBAO_0000188BAO_0000218organism-based formatC[n+]1ccc2c([nH]c3ccccc32)c1-c1ccccc1.Cc1ccc(S(=O)(=O)[O-])cc1CHEMBL1147489Bioorg Med Chem Lett2004CHEMBL295054CHEMBL11834004.89http://www.openphacts.org/units/Nanomolar76153=11=EC50nM13000.0CHEMBL364Plasmodium falciparumPlasmodium falciparum5833EC50MUO_00000650.00001320/chembl/api/data/activity?limit=20&offset=4020/chembl/api/data/activity?limit=20&offset=024267312