{"activities": [{"action_type": null, "activity_comment": null, "activity_id": 2978912, "activity_properties": [], "assay_chembl_id": "CHEMBL1044460", "assay_description": "Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration assay", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000192", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "O=c1ccc2ccccc2o1", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL1156762", "document_journal": "J Med Chem", "document_year": 2010, "ligand_efficiency": {"bei": "34.56", "le": "0.63", "lle": "3.26", "sei": "16.72"}, "modality": null, "molecule_chembl_id": "CHEMBL6466", "molecule_pref_name": "COUMARIN", "parent_molecule_chembl_id": "CHEMBL6466", "pchembl_value": "5.05", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 856407, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "Ki", "standard_units": "nM", "standard_upper_value": null, "standard_value": "8900.0", "target_chembl_id": "CHEMBL3242", "target_organism": "Homo sapiens", "target_pref_name": "Carbonic anhydrase 12", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "Ki", "units": "uM", "uo_units": "UO_0000065", "upper_value": null, "value": "8.9"}, {"action_type": null, "activity_comment": null, "activity_id": 3378462, "activity_properties": [], "assay_chembl_id": "CHEMBL1212361", "assay_description": "Inhibition of human CA12 by CO2 hydration assay", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000179", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "O=c1ccc2ccccc2o1", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL1208713", "document_journal": "Bioorg Med Chem Lett", "document_year": 2010, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL6466", "molecule_pref_name": "COUMARIN", "parent_molecule_chembl_id": "CHEMBL6466", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Micromolar", "record_id": 927779, "relation": ">", "src_id": 1, "standard_flag": 0, "standard_relation": ">", "standard_text_value": null, "standard_type": "Kinact", "standard_units": "uM", "standard_upper_value": null, "standard_value": "100.0", "target_chembl_id": "CHEMBL3242", "target_organism": "Homo sapiens", "target_pref_name": "Carbonic anhydrase 12", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "Kinact", "units": "uM", "uo_units": "UO_0000064", "upper_value": null, "value": "100.0"}, {"action_type": null, "activity_comment": null, "activity_id": 8008426, "activity_properties": [], "assay_chembl_id": "CHEMBL1941824", "assay_description": "Inhibition of human recombinant CA12 after 6 hrs by stopped flow CO2 hydration assay", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000192", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "O=c1ccc2ccccc2o1", "data_validity_comment": "Outside typical range", "data_validity_description": "Values for this activity type are unusually large/small, so may not be accurate", "document_chembl_id": "CHEMBL1938342", "document_journal": "J Med Chem", "document_year": 2011, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL6466", "molecule_pref_name": "COUMARIN", "parent_molecule_chembl_id": "CHEMBL6466", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 1570125, "relation": ">", "src_id": 1, "standard_flag": 1, "standard_relation": ">", "standard_text_value": null, "standard_type": "Ki", "standard_units": "nM", "standard_upper_value": null, "standard_value": "500000.0", "target_chembl_id": "CHEMBL3242", "target_organism": "Homo sapiens", "target_pref_name": "Carbonic anhydrase 12", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "Ki", "units": "nM", "uo_units": "UO_0000065", "upper_value": null, "value": "500000.0"}, {"action_type": null, "activity_comment": null, "activity_id": 8053875, "activity_properties": [], "assay_chembl_id": "CHEMBL1960510", "assay_description": "Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration method", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000192", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "O=c1ccc2ccccc2o1", "data_validity_comment": "Outside typical range", "data_validity_description": "Values for this activity type are unusually large/small, so may not be accurate", "document_chembl_id": "CHEMBL1955812", "document_journal": "Bioorg Med Chem Lett", "document_year": 2012, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL6466", "molecule_pref_name": "COUMARIN", "parent_molecule_chembl_id": "CHEMBL6466", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 1580929, "relation": ">", "src_id": 1, "standard_flag": 1, "standard_relation": ">", "standard_text_value": null, "standard_type": "Ki", "standard_units": "nM", "standard_upper_value": null, "standard_value": "200000.0", "target_chembl_id": "CHEMBL3242", "target_organism": "Homo sapiens", "target_pref_name": "Carbonic anhydrase 12", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "Ki", "units": "uM", "uo_units": "UO_0000065", "upper_value": null, "value": "200.0"}, {"action_type": null, "activity_comment": null, "activity_id": 8060051, "activity_properties": [], "assay_chembl_id": "CHEMBL1961264", "assay_description": "Inhibition of human carbonic anhydrase 12 after 6 hrs by stop-flow CO2 hydration assay", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000192", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "O=c1ccc2ccccc2o1", "data_validity_comment": "Outside typical range", "data_validity_description": "Values for this activity type are unusually large/small, so may not be accurate", "document_chembl_id": "CHEMBL1955798", "document_journal": "Bioorg Med Chem", "document_year": 2012, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL6466", "molecule_pref_name": "COUMARIN", "parent_molecule_chembl_id": "CHEMBL6466", "pchembl_value": null, "potential_duplicate": 1, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 1581688, "relation": ">", "src_id": 1, "standard_flag": 1, "standard_relation": ">", "standard_text_value": null, "standard_type": "Ki", "standard_units": "nM", "standard_upper_value": null, "standard_value": "200000.0", "target_chembl_id": "CHEMBL3242", "target_organism": "Homo sapiens", "target_pref_name": "Carbonic anhydrase 12", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "Ki", "units": "uM", "uo_units": "UO_0000065", "upper_value": null, "value": "200.0"}, {"action_type": null, "activity_comment": null, "activity_id": 12654041, "activity_properties": [], "assay_chembl_id": "CHEMBL2329430", "assay_description": "Inhibition of human recombinant transmembrane CA12 catalytic domain after 15 mins by stopped-flow CO2 hydration method", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000201", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "O=c1ccc2ccccc2o1", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL2321814", "document_journal": "J Med Chem", "document_year": 2013, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL6466", "molecule_pref_name": "COUMARIN", "parent_molecule_chembl_id": "CHEMBL6466", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://qudt.org/vocab/unit#Percent", "record_id": 1852995, "relation": null, "src_id": 1, "standard_flag": 0, "standard_relation": null, "standard_text_value": "Not active", "standard_type": "Inhibition", "standard_units": "%", "standard_upper_value": null, "standard_value": null, "target_chembl_id": "CHEMBL3242", "target_organism": "Homo sapiens", "target_pref_name": "Carbonic anhydrase 12", "target_tax_id": "9606", "text_value": "Not Active", "toid": null, "type": "INH", "units": null, "uo_units": "UO_0000187", "upper_value": null, "value": null}, {"action_type": null, "activity_comment": null, "activity_id": 12654126, "activity_properties": [], "assay_chembl_id": "CHEMBL2329435", "assay_description": "Inhibition of human recombinant transmembrane CA12 catalytic domain after 6 hrs by stopped-flow CO2 hydration method", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000192", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "O=c1ccc2ccccc2o1", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL2321814", "document_journal": "J Med Chem", "document_year": 2013, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL6466", "molecule_pref_name": "COUMARIN", "parent_molecule_chembl_id": "CHEMBL6466", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 1852995, "relation": ">", "src_id": 1, "standard_flag": 1, "standard_relation": ">", "standard_text_value": null, "standard_type": "Ki", "standard_units": "nM", "standard_upper_value": null, "standard_value": "100000.0", "target_chembl_id": "CHEMBL3242", "target_organism": "Homo sapiens", "target_pref_name": "Carbonic anhydrase 12", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "Ki", "units": "uM", "uo_units": "UO_0000065", "upper_value": null, "value": "100.0"}, {"action_type": null, "activity_comment": null, "activity_id": 12712383, "activity_properties": [], "assay_chembl_id": "CHEMBL2341283", "assay_description": "Inhibition of human carbonic anhydrase 12 preincubated for 6 hrs by CO2 hydration stopped-flow assay", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000192", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "O=c1ccc2ccccc2o1", "data_validity_comment": "Outside typical range", "data_validity_description": "Values for this activity type are unusually large/small, so may not be accurate", "document_chembl_id": "CHEMBL2331395", "document_journal": "Bioorg Med Chem", "document_year": 2013, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL6466", "molecule_pref_name": "COUMARIN", "parent_molecule_chembl_id": "CHEMBL6466", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 1868184, "relation": ">", "src_id": 1, "standard_flag": 1, "standard_relation": ">", "standard_text_value": null, "standard_type": "Ki", "standard_units": "nM", "standard_upper_value": null, "standard_value": "1000000.0", "target_chembl_id": "CHEMBL3242", "target_organism": "Homo sapiens", "target_pref_name": "Carbonic anhydrase 12", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "Ki", "units": "uM", "uo_units": "UO_0000065", "upper_value": null, "value": "1000.0"}, {"action_type": null, "activity_comment": null, "activity_id": 16460609, "activity_properties": [], "assay_chembl_id": "CHEMBL3760251", "assay_description": "Inhibition of human carbonic anhydrase 12 catalytic domain by Stopped-Flow CO2 Hydrase assay", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000192", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "O=c1ccc2ccccc2o1", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL3758094", "document_journal": "J Med Chem", "document_year": 2016, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL6466", "molecule_pref_name": "COUMARIN", "parent_molecule_chembl_id": "CHEMBL6466", "pchembl_value": null, "potential_duplicate": 1, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 2748644, "relation": ">", "src_id": 1, "standard_flag": 1, "standard_relation": ">", "standard_text_value": null, "standard_type": "Ki", "standard_units": "nM", "standard_upper_value": null, "standard_value": "100000.0", "target_chembl_id": "CHEMBL3242", "target_organism": "Homo sapiens", "target_pref_name": "Carbonic anhydrase 12", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "Ki", "units": "uM", "uo_units": "UO_0000065", "upper_value": null, "value": "100.0"}], "page_meta": {"limit": 20, "next": null, "offset": 0, "previous": null, "total_count": 9}}