85609CHEMBL683261Toxic concentration on HIV-1 mock infected H9 lymphocyte cellsTBAO_0000188BAO_0000219cell-based formatC=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12CHEMBL1129502J Med Chem1996CHEMBL269277BETULINIC ACIDCHEMBL2692775.85http://www.openphacts.org/units/Nanomolar2049=11=EC50nM1400.0CHEMBL614806Homo sapiensH99606EC50uMUO_00000651.4228907CHEMBL683469Anti-HIV activity against acutely infected H9 lymphocytes. Activity expressed as concentration of compound able to suppress HIV replication by 50%.FBAO_0000188BAO_0000219cell-based formatC=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12CHEMBL1131182J Med Chem1998CHEMBL269277BETULINIC ACIDCHEMBL2692775.85http://www.openphacts.org/units/Nanomolar275382=11=EC50nM1400.0CHEMBL614806Homo sapiensH99606EC50uMUO_00000651.41065683CHEMBL685683Compound was evaluated for anti-HIV activity in H9 lymphocytesFBAO_0000188BAO_0000219cell-based formatC=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12CHEMBL1130995Bioorg Med Chem Lett1998CHEMBL269277BETULINIC ACIDCHEMBL2692775.85http://www.openphacts.org/units/Nanomolar31614=11=EC50nM1400.0CHEMBL614806Homo sapiensH99606EC50uMUO_00000651.42146072CHEMBL921747Cytotoxicity against human A549 cells after 1 hr by MTT assayFBAO_0000190BAO_0000219cell-based formatC=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12CHEMBL1144753Bioorg Med Chem2008CHEMBL269277BETULINIC ACIDCHEMBL2692775.18http://www.openphacts.org/units/Nanomolar707725=11=IC50nM6650.0CHEMBL392Homo sapiensA5499606IC50uMUO_00000656.652179598CHEMBL966470Cytotoxicity against mock-infected human H9 cellsABAO_0000188BAO_0000219cell-based formatC=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12CHEMBL1155638J Nat Prod2000CHEMBL269277BETULINIC ACIDCHEMBL2692775.85http://www.openphacts.org/units/Nanomolar712201=11=EC50nM1400.0CHEMBL614806Homo sapiensH99606EC50uMUO_00000651.42995798CHEMBL1041788Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayFBAO_0000188BAO_0000219cell-based formatC=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12CHEMBL1156761J Med Chem2010CHEMBL269277BETULINIC ACIDCHEMBL2692775.98http://www.openphacts.org/units/Nanomolar856405=11=EC50nM1040.0CHEMBL5409Homo sapiensG-protein coupled bile acid receptor 19606EC50uMUO_00000651.043063772CHEMBL1044259Cytotoxicity against human HepG2 cells after 72 hrs by MTT assayFBAO_0000190BAO_0000219cell-based formatC=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12CHEMBL1152543Bioorg Med Chem2009CHEMBL269277BETULINIC ACIDCHEMBL2692777.44http://www.openphacts.org/units/Nanomolar877550=11=IC50nM36.4CHEMBL395Homo sapiensHepG29606IC50nMUO_000006536.43063773CHEMBL1044260Cytotoxicity against human Jurkat cells after 72 hrs by XTT assayFBAO_0000190BAO_0000219cell-based formatC=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12CHEMBL1152543Bioorg Med Chem2009CHEMBL269277BETULINIC ACIDCHEMBL2692777.57http://www.openphacts.org/units/Nanomolar877550=11=IC50nM26.9CHEMBL397Homo sapiensJurkat9606IC50nMUO_000006526.93063774CHEMBL1044261Cytotoxicity against human HeLa cells after 72 hrs by MTT assayFBAO_0000190BAO_0000219cell-based formatC=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12CHEMBL1152543Bioorg Med Chem2009CHEMBL269277BETULINIC ACIDCHEMBL2692777.58http://www.openphacts.org/units/Nanomolar877550=11=IC50nM26.0CHEMBL399Homo sapiensHeLa9606IC50nMUO_000006526.03107514CHEMBL1064342Cytotoxicity against human 8505C cells after 96 hrs by SRB assayFBAO_0000190BAO_0000219cell-based formatC=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12CHEMBL1159047Bioorg Med Chem2010CHEMBL269277BETULINIC ACIDCHEMBL2692775.17http://www.openphacts.org/units/Nanomolar883346=11=IC50nM6700.0CHEMBL1075387Homo sapiens8505C9606IC50uMUO_00000656.73107527CHEMBL1064341Cytotoxicity against human SW480 cells after 96 hrs by SRB assayFBAO_0000190BAO_0000219cell-based formatC=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12CHEMBL1159047Bioorg Med Chem2010CHEMBL269277BETULINIC ACIDCHEMBL2692775.19http://www.openphacts.org/units/Nanomolar883346=11=IC50nM6400.0CHEMBL612544Homo sapiensSW4809606IC50uMUO_00000656.43256019CHEMBL1114329Cytotoxicity against human SW480 cells after 96 hrs by sulforhodamine B assayFBAO_0000190BAO_0000219cell-based formatC=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12CHEMBL1156998Bioorg Med Chem2010CHEMBL269277BETULINIC ACIDCHEMBL2692775.19http://www.openphacts.org/units/Nanomolar903650=11=IC50nM6400.0CHEMBL612544Homo sapiensSW4809606IC50uMUO_00000656.43256034CHEMBL1114330Cytotoxicity against human 8505C cells after 96 hrs by sulforhodamine B assayFBAO_0000190BAO_0000219cell-based formatC=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12CHEMBL1156998Bioorg Med Chem2010CHEMBL269277BETULINIC ACIDCHEMBL2692775.17http://www.openphacts.org/units/Nanomolar903650=11=IC50nM6700.0CHEMBL1075387Homo sapiens8505C9606IC50uMUO_00000656.73310773CHEMBL1120104Cytotoxicity against human 8505C cells after 96 hrs by SRB assayFBAO_0000190BAO_0000219cell-based formatC=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12CHEMBL1155488Bioorg Med Chem Lett2010CHEMBL269277BETULINIC ACIDCHEMBL2692775.14http://www.openphacts.org/units/Nanomolar915651=11=IC50nM7260.0CHEMBL1075387Homo sapiens8505C9606IC50uMUO_00000657.263311286CHEMBL1119733Cytotoxicity against human SW480 cells after 96 hrs by SRB assayFBAO_0000190BAO_0000219cell-based formatC=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12CHEMBL1155488Bioorg Med Chem Lett2010CHEMBL269277BETULINIC ACIDCHEMBL2692775.19http://www.openphacts.org/units/Nanomolar915651=11=IC50nM6480.0CHEMBL612544Homo sapiensSW4809606IC50uMUO_00000656.483411213CHEMBL1225659Cytotoxicity against human SK-MEL-2 cells after 72 hrs by MTS assayFBAO_0000190BAO_0000219cell-based formatC=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12CHEMBL1221374Bioorg Med Chem Lett2010CHEMBL269277BETULINIC ACIDCHEMBL2692775.16http://www.openphacts.org/units/Nanomolar937818=11=IC50nM7000.0CHEMBL614917Homo sapiensSK-MEL-29606IC50uMUO_00000657.03467166CHEMBL1250716Cytotoxicity against human 8505C cells after 96 hrs by sulforhodamine B assayFBAO_0000190BAO_0000219cell-based formatC=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12CHEMBL1250553Bioorg Med Chem2010CHEMBL269277BETULINIC ACIDCHEMBL2692775.17http://www.openphacts.org/units/Nanomolar957292=11=IC50nM6700.0CHEMBL1075387Homo sapiens8505C9606IC50uMUO_00000656.73467177CHEMBL1250715Cytotoxicity against human SW480 cells after 96 hrs by sulforhodamine B assayFBAO_0000190BAO_0000219cell-based formatC=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12CHEMBL1250553Bioorg Med Chem2010CHEMBL269277BETULINIC ACIDCHEMBL2692775.19http://www.openphacts.org/units/Nanomolar957292=11=IC50nM6400.0CHEMBL612544Homo sapiensSW4809606IC50uMUO_00000656.4Inconclusive4889496CHEMBL1614079PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) FBAO_0000186BAO_0000019assay formatC=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12CHEMBL1201862CHEMBL269277BETULINIC ACIDCHEMBL2692775.50http://www.openphacts.org/units/Nanomolar1151320=71=PotencynM3162.3CHEMBL2392Homo sapiensDNA polymerase beta9606PotencyumUO_00000653.1623Active5541081CHEMBL1614290PUBCHEM_BIOASSAY: uHTS HTRF assay for identification of inhibitors of SUMOylation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2011, AID2018, AID2069, AID2614, AID2658]BBAO_0000190BAO_0000223protein complex formatC=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12CHEMBL120186211.020.21-2.068.75CHEMBL269277BETULINIC ACIDCHEMBL2692775.03http://www.openphacts.org/units/Nanomolar1151320=71=IC50nM9240.0CHEMBL2095174Homo sapiensSUMO-activating enzyme9606IC50uMUO_00000659.2420/chembl/api/data/activity.json (live re-fetch 2026-06-03: target PRESENT, best pChEMBL=5.82?limit=20&offset=20&molecule_chembl_id=CHEMBL269277&pchembl_value__gte=5&target_organism=Homo+sapiens&+target_type=SINGLE+PROTEIN%2962