{"activities": [{"action_type": null, "activity_comment": null, "activity_id": 15188548, "activity_properties": [], "assay_chembl_id": "CHEMBL3411297", "assay_description": "Inhibition of Limk1 (unknown origin)", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000190", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "COc1c(C=O)c(O)cc2c1C(=O)c1ccccc1C2=O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL3407489", "document_journal": "J Med Chem", "document_year": 2015, "ligand_efficiency": {"bei": "21.60", "le": "0.40", "lle": "4.11", "sei": "7.56"}, "modality": null, "molecule_chembl_id": "CHEMBL212948", "molecule_pref_name": "DAMNACANTHAL", "parent_molecule_chembl_id": "CHEMBL212948", "pchembl_value": "6.10", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 2288783, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "IC50", "standard_units": "nM", "standard_upper_value": null, "standard_value": "800.0", "target_chembl_id": "CHEMBL3836", "target_organism": "Homo sapiens", "target_pref_name": "LIM domain kinase 1", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "IC50", "units": "nM", "uo_units": "UO_0000065", "upper_value": null, "value": "800.0"}, {"action_type": {"action_type": "INHIBITOR", "description": "Negatively effects (inhibits) the normal functioning of the protein e.g., prevention of enzymatic reaction or activation of downstream pathway", "parent_type": "NEGATIVE MODULATOR"}, "activity_comment": null, "activity_id": 24716696, "activity_properties": [{"comments": null, "relation": "=", "result_flag": 0, "standard_relation": "=", "standard_text_value": null, "standard_type": "TIME", "standard_units": "hr", "standard_value": "1.0", "text_value": null, "type": "Time", "units": "hrs", "value": "1.0"}], "assay_chembl_id": "CHEMBL5111700", "assay_description": "Inhibition of his6 tagged LIMK1 (unknown origin) expressed in baculovirus-infected Sf9 cells measured after 1 hr in presence of ATP by fluorescence based analysis", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000190", "bao_format": "BAO_0000219", "bao_label": "cell-based format", "canonical_smiles": "COc1c(C=O)c(O)cc2c1C(=O)c1ccccc1C2=O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL5108049", "document_journal": "J Med Chem", "document_year": 2022, "ligand_efficiency": {"bei": "21.60", "le": "0.40", "lle": "4.11", "sei": "7.56"}, "modality": null, "molecule_chembl_id": "CHEMBL212948", "molecule_pref_name": "DAMNACANTHAL", "parent_molecule_chembl_id": "CHEMBL212948", "pchembl_value": "6.10", "potential_duplicate": 1, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 3854946, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "IC50", "standard_units": "nM", "standard_upper_value": null, "standard_value": "800.0", "target_chembl_id": "CHEMBL3836", "target_organism": "Homo sapiens", "target_pref_name": "LIM domain kinase 1", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "IC50", "units": "uM", "uo_units": "UO_0000065", "upper_value": null, "value": "0.8"}, {"action_type": {"action_type": "INHIBITOR", "description": "Negatively effects (inhibits) the normal functioning of the protein e.g., prevention of enzymatic reaction or activation of downstream pathway", "parent_type": "NEGATIVE MODULATOR"}, "activity_comment": null, "activity_id": 25040438, "activity_properties": [], "assay_chembl_id": "CHEMBL5244633", "assay_description": "Inhibition of LIMK1 (unknown origin)", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000190", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "COc1c(C=O)c(O)cc2c1C(=O)c1ccccc1C2=O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL5244212", "document_journal": "Eur J Med Chem", "document_year": 2018, "ligand_efficiency": {"bei": "21.60", "le": "0.40", "lle": "4.11", "sei": "7.56"}, "modality": null, "molecule_chembl_id": "CHEMBL212948", "molecule_pref_name": "DAMNACANTHAL", "parent_molecule_chembl_id": "CHEMBL212948", "pchembl_value": "6.10", "potential_duplicate": 1, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 3922581, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "IC50", "standard_units": "nM", "standard_upper_value": null, "standard_value": "800.0", "target_chembl_id": "CHEMBL3836", "target_organism": "Homo sapiens", "target_pref_name": "LIM domain kinase 1", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "IC50", "units": "uM", "uo_units": "UO_0000065", "upper_value": null, "value": "0.8"}], "page_meta": {"limit": 20, "next": null, "offset": 0, "previous": null, "total_count": 3}}