33093CHEMBL643853Antagonistic potency of compound for Alpha-1 adrenergic receptorFBAO_0000034BAO_0000019assay formatCOc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OCCHEMBL1121744J Med Chem1981CHEMBL2PRAZOSINCHEMBL28.70http://www.openphacts.org/units/Nanomolar37290=11=KdnM1.995CHEMBL1907610Rattus norvegicusAdrenergic receptor alpha-110116pA2UO_00000658.733094CHEMBL641370Antagonistic potency of compound for Alpha-2 adrenergic receptorFBAO_0000034BAO_0000019assay formatCOc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OCCHEMBL1121744J Med Chem1981CHEMBL2PRAZOSINCHEMBL25.60http://www.openphacts.org/units/Nanomolar37290=11=KdnM2511.89CHEMBL2093864Rattus norvegicusAdrenergic receptor alpha-210116pA2UO_00000655.633095CHEMBL645499Ratio of alpha1, alpha2 adrenoceptor antagonistic activity was expressed as slelctivity ratioFBAO_0000193BAO_0000019assay formatCOc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OCCHEMBL1121744J Med Chem1981CHEMBL2PRAZOSINCHEMBL237290=1=Ratio1258.9CHEMBL1907610Rattus norvegicusAdrenergic receptor alpha-110116Ratio1258.934164CHEMBL646168Compound was tested for its binding affinity towards Alpha-1A adrenergic receptor using [3H]prazosin from rat submaxillary glandBBAO_0000192BAO_0000357single protein formatCOc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OCCHEMBL1131209J Med Chem199823.420.447.208.40CHEMBL2PRAZOSINCHEMBL28.98http://www.openphacts.org/units/Nanomolar63313=11=KinM1.05CHEMBL319Rattus norvegicusAlpha-1A adrenergic receptor10116KinMUO_00000651.0534165CHEMBL647286Compound was tested for its binding affinity towards Alpha-1B adrenergic receptor using [3H]prazosin from rat liverBBAO_0000192BAO_0000019assay formatCOc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OCCHEMBL1131209J Med Chem199822.260.426.757.98CHEMBL2PRAZOSINCHEMBL28.53http://www.openphacts.org/units/Nanomolar63313=11=KinM2.93CHEMBL315Rattus norvegicusAlpha-1B adrenergic receptor10116KinMUO_00000652.9340935CHEMBL702885Binding constant against human serum albumin (HSA)BBAO_0000179BAO_0000357single protein formatCOc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OCCHEMBL1134302J Med Chem2001CHEMBL2PRAZOSINCHEMBL2264401=1=Log K'0.06CHEMBL3253Homo sapiensAlbumin9606Log K'0.0656881CHEMBL644561Antagonism against Alpha-1 adrenergic receptor of rat aortaFBAO_0000034BAO_0000221tissue-based formatCOc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OCCHEMBL1128861Bioorg Med Chem Lett1995CHEMBL2PRAZOSINCHEMBL210.38http://www.openphacts.org/units/Nanomolar312967=11=KdnM0.04169CHEMBL1907610Rattus norvegicusAdrenergic receptor alpha-110116pA2UO_000006510.3858305CHEMBL647535Induction of ptosis after subcutaneous administration at alpha-1 adrenergic receptor in ratBBAO_0003036BAO_0000019assay formatCOc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OCCHEMBL1128459J Med Chem1995CHEMBL2PRAZOSINCHEMBL2250187=11=ED50mg.kg-10.04CHEMBL1907610Rattus norvegicusAdrenergic receptor alpha-110116ED50mg kg-1UO_00003080.0458306CHEMBL670369Inhibitory activity against methyl-phenidate-induced gnawing at dopamine receptor D2 in ratBBAO_0000179BAO_0000019assay formatCOc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OCCHEMBL1128459J Med Chem1995CHEMBL2PRAZOSINCHEMBL2250187>11>ID50mg.kg-110.0CHEMBL339Rattus norvegicusD(2) dopamine receptor10116ID50mg kg-1UO_000030810.0106599CHEMBL651984Binding affinity by its ability to displace [3H]prazosin radioligand from Alpha-1 adrenergic receptor on rat cerebral cortexBBAO_0000192BAO_0000221tissue-based formatCOc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OCCHEMBL1135045Bioorg Med Chem Lett200225.090.477.848.99CHEMBL2PRAZOSINCHEMBL29.621http://www.openphacts.org/units/Nanomolar265560=11=KinM0.24CHEMBL1907610Rattus norvegicusAdrenergic receptor alpha-110116KinMUO_00000650.24140968CHEMBL649149Ability (10 ug/kg) to inhibit binding of [125I]iododexetimide to adrenergic receptor in miceBBAO_0000190BAO_0000019assay formatCOc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OCCHEMBL1124460J Med Chem1989CHEMBL2PRAZOSINCHEMBL24.89http://www.openphacts.org/units/Nanomolar6889=11=IC50nM13000.0CHEMBL612545UncheckedIC50nMUO_000006513000.0160411CHEMBL787562Antihypertensive activity as percentage fall in systolic blood pressure in spontaneously hypertensive rats 1 hr after 12.5 mg/kg po administrationFBAO_0000179BAO_0000218organism-based formatCOc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OCCHEMBL1122367J Med Chem1983CHEMBL2PRAZOSINCHEMBL2http://qudt.org/vocab/unit#Percent49578=1=Fall%26.0CHEMBL376Rattus norvegicusRattus norvegicus10116Fall%UO_000018726.0160412CHEMBL787569Antihypertensive activity as percentage fall in systolic blood pressure in spontaneously hypertensive rats 2 hr after 12.5 mg/kg po administrationFBAO_0000179BAO_0000218organism-based formatCOc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OCCHEMBL1122367J Med Chem1983CHEMBL2PRAZOSINCHEMBL2http://qudt.org/vocab/unit#Percent49578=1=Fall%46.0CHEMBL376Rattus norvegicusRattus norvegicus10116Fall%UO_000018746.0160413CHEMBL787576Antihypertensive activity as percentage fall in systolic blood pressure in spontaneously hypertensive rats 3h after 12.5 mg/kg po administrationFBAO_0000179BAO_0000218organism-based formatCOc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OCCHEMBL1122367J Med Chem1983CHEMBL2PRAZOSINCHEMBL2http://qudt.org/vocab/unit#Percent49578=1=Fall%36.0CHEMBL376Rattus norvegicusRattus norvegicus10116Fall%UO_000018736.0160414CHEMBL786855Antihypertensive activity as percentage fall in systolic blood pressure in spontaneously hypertensive rats 4 hr after 12.5 mg/kg po administrationFBAO_0000179BAO_0000218organism-based formatCOc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OCCHEMBL1122367J Med Chem1983CHEMBL2PRAZOSINCHEMBL2http://qudt.org/vocab/unit#Percent49578=1=Fall%31.0CHEMBL376Rattus norvegicusRattus norvegicus10116Fall%UO_000018731.0160415CHEMBL785301Antihypertensive activity as percentage fall in systolic blood pressure in spontaneously hypertensive rats 1 hr after 0.31 mg/kg po administrationFBAO_0000179BAO_0000218organism-based formatCOc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OCCHEMBL1122367J Med Chem1983CHEMBL2PRAZOSINCHEMBL2http://qudt.org/vocab/unit#Percent49578=1=Fall%19.0CHEMBL376Rattus norvegicusRattus norvegicus10116Fall%UO_000018719.0160416CHEMBL787568Antihypertensive activity as percentage fall in systolic blood pressure in spontaneously hypertensive rats 2 hr after 0.31 mg/kg po administrationFBAO_0000179BAO_0000218organism-based formatCOc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OCCHEMBL1122367J Med Chem1983CHEMBL2PRAZOSINCHEMBL2http://qudt.org/vocab/unit#Percent49578=1=Fall%19.0CHEMBL376Rattus norvegicusRattus norvegicus10116Fall%UO_000018719.0160417CHEMBL787575Antihypertensive activity as percentage fall in systolic blood pressure in spontaneously hypertensive rats 3h after 0.31 mg/kg po administrationFBAO_0000179BAO_0000218organism-based formatCOc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OCCHEMBL1122367J Med Chem1983CHEMBL2PRAZOSINCHEMBL2http://qudt.org/vocab/unit#Percent49578=1=Fall%21.0CHEMBL376Rattus norvegicusRattus norvegicus10116Fall%UO_000018721.0160418CHEMBL786854Antihypertensive activity as percentage fall in systolic blood pressure in spontaneously hypertensive rats 4 hr after 0.31 mg/kg po administrationFBAO_0000179BAO_0000218organism-based formatCOc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OCCHEMBL1122367J Med Chem1983CHEMBL2PRAZOSINCHEMBL2http://qudt.org/vocab/unit#Percent49578=1=Fall%26.0CHEMBL376Rattus norvegicusRattus norvegicus10116Fall%UO_000018726.0173829CHEMBL795985Antagonist activity against phenylephrine-induced alpha1- adrenoceptor mediated vasoconstriction in pithed normotensive rats. FBAO_0000034BAO_0000019assay formatCOc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OCCHEMBL1122788J Med Chem1984CHEMBL2PRAZOSINCHEMBL28.33http://www.openphacts.org/units/Nanomolar286608=11=KdnM4.677CHEMBL1907610Rattus norvegicusAdrenergic receptor alpha-110116pA2UO_00000658.3320/chembl/api/data/activity?limit=20&offset=20&molecule_chembl_id=CHEMBL21941