{"activities": [{"action_type": null, "activity_comment": null, "activity_id": 2057038, "activity_properties": [], "assay_chembl_id": "CHEMBL926264", "assay_description": "Inhibition of aryl hydrocarbon receptor", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000190", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL1140636", "document_journal": "Bioorg Med Chem", "document_year": 2007, "ligand_efficiency": {"bei": "26.39", "le": "0.49", "lle": "5.27", "sei": "6.80"}, "modality": null, "molecule_chembl_id": "CHEMBL150", "molecule_pref_name": "KAEMPFEROL", "parent_molecule_chembl_id": "CHEMBL150", "pchembl_value": "7.55", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 683240, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "IC50", "standard_units": "nM", "standard_upper_value": null, "standard_value": "28.0", "target_chembl_id": "CHEMBL3201", "target_organism": "Homo sapiens", "target_pref_name": "Aryl hydrocarbon receptor", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "IC50", "units": "nM", "uo_units": "UO_0000065", "upper_value": null, "value": "28.0"}, {"action_type": null, "activity_comment": null, "activity_id": 2465282, "activity_properties": [], "assay_chembl_id": "CHEMBL958789", "assay_description": "Inhibition of human recombinant 17beta-HSD2 expressed in HEK293 cell lysate assessed as conversion of radiolabeled estrone to estradiol", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000190", "bao_format": "BAO_0000219", "bao_label": "cell-based format", "canonical_smiles": "O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL1157467", "document_journal": "J Med Chem", "document_year": 2008, "ligand_efficiency": {"bei": "22.51", "le": "0.42", "lle": "4.16", "sei": "5.80"}, "modality": null, "molecule_chembl_id": "CHEMBL150", "molecule_pref_name": "KAEMPFEROL", "parent_molecule_chembl_id": "CHEMBL150", "pchembl_value": "6.44", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 721130, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "IC50", "standard_units": "nM", "standard_upper_value": null, "standard_value": "360.0", "target_chembl_id": "CHEMBL2789", "target_organism": "Homo sapiens", "target_pref_name": "17-beta-hydroxysteroid dehydrogenase type 2", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "IC50", "units": "uM", "uo_units": "UO_0000065", "upper_value": null, "value": "0.36"}, {"action_type": null, "activity_comment": null, "activity_id": 3409856, "activity_properties": [], "assay_chembl_id": "CHEMBL1225716", "assay_description": "Inhibition of human CYP1A2 by EROD assay", "assay_type": "A", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000190", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL1221335", "document_journal": "Bioorg Med Chem", "document_year": 2010, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL150", "molecule_pref_name": "KAEMPFEROL", "parent_molecule_chembl_id": "CHEMBL150", "pchembl_value": "6.14", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 937866, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "IC50", "standard_units": "nM", "standard_upper_value": null, "standard_value": "716.0", "target_chembl_id": "CHEMBL3356", "target_organism": "Homo sapiens", "target_pref_name": "Cytochrome P450 1A2", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "IC50", "units": "nM", "uo_units": "UO_0000065", "upper_value": null, "value": "716.0"}, {"action_type": null, "activity_comment": null, "activity_id": 3409857, "activity_properties": [], "assay_chembl_id": "CHEMBL1225717", "assay_description": "Inhibition of human CYP1A1 by EROD assay", "assay_type": "A", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000190", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL1221335", "document_journal": "Bioorg Med Chem", "document_year": 2010, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL150", "molecule_pref_name": "KAEMPFEROL", "parent_molecule_chembl_id": "CHEMBL150", "pchembl_value": "6.20", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 937866, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "IC50", "standard_units": "nM", "standard_upper_value": null, "standard_value": "632.0", "target_chembl_id": "CHEMBL2231", "target_organism": "Homo sapiens", "target_pref_name": "Cytochrome P450 1A1", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "IC50", "units": "nM", "uo_units": "UO_0000065", "upper_value": null, "value": "632.0"}, {"action_type": null, "activity_comment": null, "activity_id": 3409873, "activity_properties": [], "assay_chembl_id": "CHEMBL1225718", "assay_description": "Inhibition of human CYP1B1 by EROD assay", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000190", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL1221335", "document_journal": "Bioorg Med Chem", "document_year": 2010, "ligand_efficiency": {"bei": "25.60", "le": "0.48", "lle": "5.05", "sei": "6.59"}, "modality": null, "molecule_chembl_id": "CHEMBL150", "molecule_pref_name": "KAEMPFEROL", "parent_molecule_chembl_id": "CHEMBL150", "pchembl_value": "7.33", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 937866, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "IC50", "standard_units": "nM", "standard_upper_value": null, "standard_value": "47.0", "target_chembl_id": "CHEMBL4878", "target_organism": "Homo sapiens", "target_pref_name": "Cytochrome P450 1B1", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "IC50", "units": "nM", "uo_units": "UO_0000065", "upper_value": null, "value": "47.0"}, {"action_type": null, "activity_comment": "Inconclusive", "activity_id": 5017047, "activity_properties": [], "assay_chembl_id": "CHEMBL1614027", "assay_description": "PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ]", "assay_type": "A", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000186", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL1201862", "document_journal": null, "document_year": null, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL150", "molecule_pref_name": "KAEMPFEROL", "parent_molecule_chembl_id": "CHEMBL150", "pchembl_value": "8.89", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 978032, "relation": "=", "src_id": 7, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "Potency", "standard_units": "nM", "standard_upper_value": null, "standard_value": "1.3", "target_chembl_id": "CHEMBL3397", "target_organism": "Homo sapiens", "target_pref_name": "Cytochrome P450 2C9", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "Potency", "units": "um", "uo_units": "UO_0000065", "upper_value": null, "value": "0.0013"}, {"action_type": null, "activity_comment": "inconclusive", "activity_id": 5992719, "activity_properties": [], "assay_chembl_id": "CHEMBL1741325", "assay_description": "PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000186", "bao_format": "BAO_0000019", "bao_label": "assay format", "canonical_smiles": "O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL1201862", "document_journal": null, "document_year": null, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL150", "molecule_pref_name": "KAEMPFEROL", "parent_molecule_chembl_id": "CHEMBL150", "pchembl_value": "8.90", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 978032, "relation": "=", "src_id": 7, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "AC50", "standard_units": "nM", "standard_upper_value": null, "standard_value": "1.259", "target_chembl_id": "CHEMBL3397", "target_organism": "Homo sapiens", "target_pref_name": "Cytochrome P450 2C9", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "AC50", "units": "uM", "uo_units": "UO_0000065", "upper_value": null, "value": "0.001258925"}, {"action_type": null, "activity_comment": "Active", "activity_id": 6055594, "activity_properties": [], "assay_chembl_id": "CHEMBL1741322", "assay_description": "PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000186", "bao_format": "BAO_0000019", "bao_label": "assay format", "canonical_smiles": "O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL1201862", "document_journal": null, "document_year": null, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL150", "molecule_pref_name": "KAEMPFEROL", "parent_molecule_chembl_id": "CHEMBL150", "pchembl_value": "7.10", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 978032, "relation": "=", "src_id": 7, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "AC50", "standard_units": "nM", "standard_upper_value": null, "standard_value": "79.43", "target_chembl_id": "CHEMBL3356", "target_organism": "Homo sapiens", "target_pref_name": "Cytochrome P450 1A2", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "AC50", "units": "uM", "uo_units": "UO_0000065", "upper_value": null, "value": "0.079432823"}, {"action_type": null, "activity_comment": null, "activity_id": 6207654, "activity_properties": [], "assay_chembl_id": "CHEMBL1780345", "assay_description": "Inhibition of CYP1A1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufin", "assay_type": "A", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000192", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL1777768", "document_journal": "Bioorg Med Chem", "document_year": 2011, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL150", "molecule_pref_name": "KAEMPFEROL", "parent_molecule_chembl_id": "CHEMBL150", "pchembl_value": "6.12", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 1423483, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "Ki", "standard_units": "nM", "standard_upper_value": null, "standard_value": "750.0", "target_chembl_id": "CHEMBL2231", "target_organism": "Homo sapiens", "target_pref_name": "Cytochrome P450 1A1", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "Ki", "units": "uM", "uo_units": "UO_0000065", "upper_value": null, "value": "0.75"}, {"action_type": null, "activity_comment": null, "activity_id": 6207668, "activity_properties": [], "assay_chembl_id": "CHEMBL1780346", "assay_description": "Inhibition of CYP1B1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufin", "assay_type": "A", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000192", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL1777768", "document_journal": "Bioorg Med Chem", "document_year": 2011, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL150", "molecule_pref_name": "KAEMPFEROL", "parent_molecule_chembl_id": "CHEMBL150", "pchembl_value": "7.37", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 1423483, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "Ki", "standard_units": "nM", "standard_upper_value": null, "standard_value": "43.0", "target_chembl_id": "CHEMBL4878", "target_organism": "Homo sapiens", "target_pref_name": "Cytochrome P450 1B1", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "Ki", "units": "uM", "uo_units": "UO_0000065", "upper_value": null, "value": "0.043"}, {"action_type": null, "activity_comment": null, "activity_id": 15752880, "activity_properties": [], "assay_chembl_id": "CHEMBL3631191", "assay_description": "Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assay", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000192", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL3627624", "document_journal": "Bioorg Med Chem", "document_year": 2015, "ligand_efficiency": {"bei": "26.56", "le": "0.49", "lle": "5.32", "sei": "6.84"}, "modality": null, "molecule_chembl_id": "CHEMBL150", "molecule_pref_name": "KAEMPFEROL", "parent_molecule_chembl_id": "CHEMBL150", "pchembl_value": "7.60", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 2507025, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "Ki", "standard_units": "nM", "standard_upper_value": null, "standard_value": "25.0", "target_chembl_id": "CHEMBL2326", "target_organism": "Homo sapiens", "target_pref_name": "Carbonic anhydrase 7", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "Ki", "units": "nM", "uo_units": "UO_0000065", "upper_value": null, "value": "25.0"}, {"action_type": null, "activity_comment": null, "activity_id": 15752902, "activity_properties": [], "assay_chembl_id": "CHEMBL3631192", "assay_description": "Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assay", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000192", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL3627624", "document_journal": "Bioorg Med Chem", "document_year": 2015, "ligand_efficiency": {"bei": "23.88", "le": "0.44", "lle": "4.56", "sei": "6.15"}, "modality": null, "molecule_chembl_id": "CHEMBL150", "molecule_pref_name": "KAEMPFEROL", "parent_molecule_chembl_id": "CHEMBL150", "pchembl_value": "6.84", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 2507025, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "Ki", "standard_units": "nM", "standard_upper_value": null, "standard_value": "145.9", "target_chembl_id": "CHEMBL3242", "target_organism": "Homo sapiens", "target_pref_name": "Carbonic anhydrase 12", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "Ki", "units": "nM", "uo_units": "UO_0000065", "upper_value": null, "value": "145.9"}, {"action_type": null, "activity_comment": null, "activity_id": 16595827, "activity_properties": [], "assay_chembl_id": "CHEMBL3810649", "assay_description": "Inhibition of tyrosinase (unknown origin) using L-tyrosine as substrate assessed as oxidation of L-tyrosine after 15 mins", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000190", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL3808312", "document_journal": "J Nat Prod", "document_year": 2016, "ligand_efficiency": {"bei": "20.96", "le": "0.39", "lle": "3.72", "sei": "5.40"}, "modality": null, "molecule_chembl_id": "CHEMBL150", "molecule_pref_name": "KAEMPFEROL", "parent_molecule_chembl_id": "CHEMBL150", "pchembl_value": "6.00", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 2779690, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "IC50", "standard_units": "nM", "standard_upper_value": null, "standard_value": "1000.0", "target_chembl_id": "CHEMBL1973", "target_organism": "Homo sapiens", "target_pref_name": "Tyrosinase", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "IC50", "units": "uM", "uo_units": "UO_0000065", "upper_value": null, "value": "1.0"}, {"action_type": null, "activity_comment": null, "activity_id": 16766139, "activity_properties": [], "assay_chembl_id": "CHEMBL3863231", "assay_description": "Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichia coli BL21 by Cheng-Prusoff analysis", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000192", "bao_format": "BAO_0000019", "bao_label": "assay format", "canonical_smiles": "O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL3862005", "document_journal": "Bioorg Med Chem Lett", "document_year": 2016, "ligand_efficiency": {"bei": "24.03", "le": "0.45", "lle": "4.60", "sei": "6.19"}, "modality": null, "molecule_chembl_id": "CHEMBL150", "molecule_pref_name": "KAEMPFEROL", "parent_molecule_chembl_id": "CHEMBL150", "pchembl_value": "6.88", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 2803158, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "Ki", "standard_units": "nM", "standard_upper_value": null, "standard_value": "132.0", "target_chembl_id": "CHEMBL1795168", "target_organism": "Homo sapiens", "target_pref_name": "CDGSH iron-sulfur domain-containing protein 1", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "Ki", "units": "uM", "uo_units": "UO_0000065", "upper_value": null, "value": "0.132"}, {"action_type": null, "activity_comment": null, "activity_id": 18451085, "activity_properties": [], "assay_chembl_id": "CHEMBL4178552", "assay_description": "Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation counting method", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000190", "bao_format": "BAO_0000019", "bao_label": "assay format", "canonical_smiles": "O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL4177545", "document_journal": "J Nat Prod", "document_year": 2017, "ligand_efficiency": {"bei": "22.51", "le": "0.42", "lle": "4.16", "sei": "5.80"}, "modality": null, "molecule_chembl_id": "CHEMBL150", "molecule_pref_name": "KAEMPFEROL", "parent_molecule_chembl_id": "CHEMBL150", "pchembl_value": "6.44", "potential_duplicate": 1, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 3062042, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "IC50", "standard_units": "nM", "standard_upper_value": null, "standard_value": "360.0", "target_chembl_id": "CHEMBL2789", "target_organism": "Homo sapiens", "target_pref_name": "17-beta-hydroxysteroid dehydrogenase type 2", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "IC50", "units": "uM", "uo_units": "UO_0000065", "upper_value": null, "value": "0.36"}, {"action_type": null, "activity_comment": null, "activity_id": 18662270, "activity_properties": [], "assay_chembl_id": "CHEMBL4232373", "assay_description": "Inhibition of DPP4 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 4 secs followed by substrate addition and measured after 30 mins by luminescence assay", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000190", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL4229387", "document_journal": "Eur J Med Chem", "document_year": 2018, "ligand_efficiency": {"bei": "22.04", "le": "0.41", "lle": "4.03", "sei": "5.68"}, "modality": null, "molecule_chembl_id": "CHEMBL150", "molecule_pref_name": "KAEMPFEROL", "parent_molecule_chembl_id": "CHEMBL150", "pchembl_value": "6.31", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 3099350, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "IC50", "standard_units": "nM", "standard_upper_value": null, "standard_value": "490.0", "target_chembl_id": "CHEMBL284", "target_organism": "Homo sapiens", "target_pref_name": "Dipeptidyl peptidase 4", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "IC50", "units": "uM", "uo_units": "UO_0000065", "upper_value": null, "value": "0.49"}, {"action_type": null, "activity_comment": null, "activity_id": 19112033, "activity_properties": [], "assay_chembl_id": "CHEMBL4370675", "assay_description": "Inhibition of human recombinant CK2 expressed in Escherichia coli using RRRADDSDDDDD as substrate after 10 mins in presence of [gamma-32P]ATP", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000190", "bao_format": "BAO_0000019", "bao_label": "assay format", "canonical_smiles": "O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL4368927", "document_journal": "Bioorg Med Chem", "document_year": 2019, "ligand_efficiency": {"bei": "22.35", "le": "0.42", "lle": "4.12", "sei": "5.76"}, "modality": null, "molecule_chembl_id": "CHEMBL150", "molecule_pref_name": "KAEMPFEROL", "parent_molecule_chembl_id": "CHEMBL150", "pchembl_value": "6.40", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 3188937, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "IC50", "standard_units": "nM", "standard_upper_value": null, "standard_value": "400.0", "target_chembl_id": "CHEMBL3832943", "target_organism": "Homo sapiens", "target_pref_name": "Casein kinase 2", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "IC50", "units": "uM", "uo_units": "UO_0000065", "upper_value": null, "value": "0.4"}, {"action_type": {"action_type": "INHIBITOR", "description": "Negatively effects (inhibits) the normal functioning of the protein e.g., prevention of enzymatic reaction or activation of downstream pathway", "parent_type": "NEGATIVE MODULATOR"}, "activity_comment": null, "activity_id": 25690650, "activity_properties": [], "assay_chembl_id": "CHEMBL5382182", "assay_description": "Binding affinity to CK2 (unknown origin)", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000192", "bao_format": "BAO_0000224", "bao_label": "protein format", "canonical_smiles": "O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL5380797", "document_journal": "J Med Chem", "document_year": 2023, "ligand_efficiency": {"bei": "23.33", "le": "0.43", "lle": "4.40", "sei": "6.01"}, "modality": null, "molecule_chembl_id": "CHEMBL150", "molecule_pref_name": "KAEMPFEROL", "parent_molecule_chembl_id": "CHEMBL150", "pchembl_value": "6.68", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 4003855, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "Ki", "standard_units": "nM", "standard_upper_value": null, "standard_value": "210.0", "target_chembl_id": "CHEMBL3832943", "target_organism": "Homo sapiens", "target_pref_name": "Casein kinase 2", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "Ki", "units": "uM", "uo_units": "UO_0000065", "upper_value": null, "value": "0.21"}], "page_meta": {"limit": 20, "next": null, "offset": 0, "previous": null, "total_count": 18}}