{"action_type": {"action_type": "ANTAGONIST", "description": "Binds to a receptor and prevents activation by an agonist through competing for the binding site", "parent_type": "NEGATIVE MODULATOR"}, "activity_comment": null, "activity_id": 25073082, "activity_properties": [], "assay_chembl_id": "CHEMBL5253448", "assay_description": "Antagonist activity at TRPM8 (unknown origin)", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000190", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "CCCCCc1cc(O)c2c(c1)OC(C)(C)[C@@H]1CCC(C)=C[C@@H]21", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL5252528", "document_journal": "J Med Chem", "document_year": 2016, "ligand_efficiency": {"bei": "21.61", "le": "0.40", "lle": "1.06", "sei": "23.07"}, "modality": null, "molecule_chembl_id": "CHEMBL465", "molecule_pref_name": "DRONABINOL", "parent_molecule_chembl_id": "CHEMBL465", "pchembl_value": "6.80", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 3930156, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "IC50", "standard_units": "nM", "standard_upper_value": null, "standard_value": "160.0", "target_chembl_id": "CHEMBL1075319", "target_organism": "Homo sapiens", "target_pref_name": "Transient receptor potential cation channel subfamily M member 8", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "IC50", "units": "uM", "uo_units": "UO_0000065", "upper_value": null, "value": "0.16"}