{"activities": [{"action_type": null, "activity_comment": null, "activity_id": 13368755, "activity_properties": [], "assay_chembl_id": "CHEMBL2404363", "assay_description": "Antidiabetic activity in obese human assessed as body weight reduction at 3 mg relative to placebo", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0001103", "bao_format": "BAO_0000218", "bao_label": "organism-based format", "canonical_smiles": "CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)C(C)C)[C@@H](C)CC)C(=O)O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL2401711", "document_journal": "Bioorg Med Chem Lett", "document_year": 2013, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL4084119", "molecule_pref_name": "LIRAGLUTIDE", "parent_molecule_chembl_id": "CHEMBL4084119", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://qudt.org/vocab/unit#Percent", "record_id": 1904700, "relation": "=", "src_id": 1, "standard_flag": 0, "standard_relation": "=", "standard_text_value": null, "standard_type": "Activity", "standard_units": "%", "standard_upper_value": null, "standard_value": "6.0", "target_chembl_id": "CHEMBL372", "target_organism": "Homo sapiens", "target_pref_name": "Homo sapiens", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "Activity", "units": "%", "uo_units": "UO_0000187", "upper_value": null, "value": "6.0"}, {"action_type": null, "activity_comment": null, "activity_id": 13368757, "activity_properties": [], "assay_chembl_id": "CHEMBL2404365", "assay_description": "Antidiabetic activity in type 2 diabetes patient assessed as reduction of HbA1c at 1.8 mg, qd after 26 weeks relative to control", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0001103", "bao_format": "BAO_0000218", "bao_label": "organism-based format", "canonical_smiles": "CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)C(C)C)[C@@H](C)CC)C(=O)O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL2401711", "document_journal": "Bioorg Med Chem Lett", "document_year": 2013, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL4084119", "molecule_pref_name": "LIRAGLUTIDE", "parent_molecule_chembl_id": "CHEMBL4084119", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://qudt.org/vocab/unit#Percent", "record_id": 1904700, "relation": "=", "src_id": 1, "standard_flag": 0, "standard_relation": "=", "standard_text_value": null, "standard_type": "Activity", "standard_units": "%", "standard_upper_value": null, "standard_value": "1.12", "target_chembl_id": "CHEMBL372", "target_organism": "Homo sapiens", "target_pref_name": "Homo sapiens", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "Activity", "units": "%", "uo_units": "UO_0000187", "upper_value": null, "value": "1.12"}, {"action_type": null, "activity_comment": null, "activity_id": 13368758, "activity_properties": [], "assay_chembl_id": "CHEMBL2404366", "assay_description": "Antidiabetic activity in type 2 diabetes patient assessed as body weight loss at 1.2 to 1.8 mg after 26 weeks relative to control", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000181", "bao_format": "BAO_0000218", "bao_label": "organism-based format", "canonical_smiles": "CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)C(C)C)[C@@H](C)CC)C(=O)O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL2401711", "document_journal": "Bioorg Med Chem Lett", "document_year": 2013, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL4084119", "molecule_pref_name": "LIRAGLUTIDE", "parent_molecule_chembl_id": "CHEMBL4084119", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://qudt.org/vocab/unit#Kilogram", "record_id": 1904700, "relation": "=", "src_id": 1, "standard_flag": 0, "standard_relation": "=", "standard_text_value": null, "standard_type": "Activity", "standard_units": "Kg", "standard_upper_value": null, "standard_value": "2.0", "target_chembl_id": "CHEMBL372", "target_organism": "Homo sapiens", "target_pref_name": "Homo sapiens", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "Activity", "units": "Kg", "uo_units": "UO_0000009", "upper_value": null, "value": "2.0"}, {"action_type": null, "activity_comment": null, "activity_id": 13368759, "activity_properties": [], "assay_chembl_id": "CHEMBL2404948", "assay_description": "Antidiabetic activity in type 2 diabetes patient assessed as reduction of HbA1c at 1.2 to 1.8 mg after 26 weeks relative to control", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0001103", "bao_format": "BAO_0000218", "bao_label": "organism-based format", "canonical_smiles": "CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)C(C)C)[C@@H](C)CC)C(=O)O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL2401711", "document_journal": "Bioorg Med Chem Lett", "document_year": 2013, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL4084119", "molecule_pref_name": "LIRAGLUTIDE", "parent_molecule_chembl_id": "CHEMBL4084119", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://qudt.org/vocab/unit#Percent", "record_id": 1904700, "relation": "=", "src_id": 1, "standard_flag": 0, "standard_relation": "=", "standard_text_value": null, "standard_type": "Activity", "standard_units": "%", "standard_upper_value": null, "standard_value": "1.1", "target_chembl_id": "CHEMBL372", "target_organism": "Homo sapiens", "target_pref_name": "Homo sapiens", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "Activity", "units": "%", "uo_units": "UO_0000187", "upper_value": null, "value": "1.1"}, {"action_type": null, "activity_comment": null, "activity_id": 13368760, "activity_properties": [], "assay_chembl_id": "CHEMBL2404367", "assay_description": "Binding affinity to serum albumin (unknown origin) relative to control", "assay_type": "A", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0001103", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)C(C)C)[C@@H](C)CC)C(=O)O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL2401711", "document_journal": "Bioorg Med Chem Lett", "document_year": 2013, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL4084119", "molecule_pref_name": "LIRAGLUTIDE", "parent_molecule_chembl_id": "CHEMBL4084119", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://qudt.org/vocab/unit#Percent", "record_id": 1904700, "relation": "=", "src_id": 1, "standard_flag": 0, "standard_relation": "=", "standard_text_value": null, "standard_type": "Activity", "standard_units": "%", "standard_upper_value": null, "standard_value": "99.0", "target_chembl_id": "CHEMBL3253", "target_organism": "Homo sapiens", "target_pref_name": "Albumin", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "Activity", "units": "%", "uo_units": "UO_0000187", "upper_value": null, "value": "99.0"}, {"action_type": null, "activity_comment": null, "activity_id": 13368765, "activity_properties": [], "assay_chembl_id": "CHEMBL2404951", "assay_description": "Half life in human", "assay_type": "A", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0002115", "bao_format": "BAO_0000218", "bao_label": "organism-based format", "canonical_smiles": "CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)C(C)C)[C@@H](C)CC)C(=O)O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL2401711", "document_journal": "Bioorg Med Chem Lett", "document_year": 2013, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL4084119", "molecule_pref_name": "LIRAGLUTIDE", "parent_molecule_chembl_id": "CHEMBL4084119", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://qudt.org/vocab/unit#Hour", "record_id": 1904700, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "T1/2", "standard_units": "hr", "standard_upper_value": null, "standard_value": "264.0", "target_chembl_id": "CHEMBL372", "target_organism": "Homo sapiens", "target_pref_name": "Homo sapiens", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "t1/2", "units": "day", "uo_units": "UO_0000032", "upper_value": null, "value": "11.0"}, {"action_type": null, "activity_comment": null, "activity_id": 13368768, "activity_properties": [], "assay_chembl_id": "CHEMBL2404953", "assay_description": "Antidiabetic activity in type 2 diabetes patient assessed as reduction of body weight measured after 26 weeks", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000181", "bao_format": "BAO_0000218", "bao_label": "organism-based format", "canonical_smiles": "CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)C(C)C)[C@@H](C)CC)C(=O)O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL2401711", "document_journal": "Bioorg Med Chem Lett", "document_year": 2013, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL4084119", "molecule_pref_name": "LIRAGLUTIDE", "parent_molecule_chembl_id": "CHEMBL4084119", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://qudt.org/vocab/unit#Kilogram", "record_id": 1904700, "relation": "=", "src_id": 1, "standard_flag": 0, "standard_relation": "=", "standard_text_value": null, "standard_type": "Activity", "standard_units": "Kg", "standard_upper_value": null, "standard_value": "2.7", "target_chembl_id": "CHEMBL372", "target_organism": "Homo sapiens", "target_pref_name": "Homo sapiens", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "Activity", "units": "Kg", "uo_units": "UO_0000009", "upper_value": null, "value": "2.7"}, {"action_type": null, "activity_comment": null, "activity_id": 13368770, "activity_properties": [], "assay_chembl_id": "CHEMBL2404958", "assay_description": "Antidiabetic activity in type 2 diabetes patient assessed as reduction of HbA1c measured after 26 weeks relative to control", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0001103", "bao_format": "BAO_0000218", "bao_label": "organism-based format", "canonical_smiles": "CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)C(C)C)[C@@H](C)CC)C(=O)O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL2401711", "document_journal": "Bioorg Med Chem Lett", "document_year": 2013, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL4084119", "molecule_pref_name": "LIRAGLUTIDE", "parent_molecule_chembl_id": "CHEMBL4084119", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://qudt.org/vocab/unit#Percent", "record_id": 1904700, "relation": "=", "src_id": 1, "standard_flag": 0, "standard_relation": "=", "standard_text_value": null, "standard_type": "Activity", "standard_units": "%", "standard_upper_value": null, "standard_value": "1.3", "target_chembl_id": "CHEMBL372", "target_organism": "Homo sapiens", "target_pref_name": "Homo sapiens", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "Activity", "units": "%", "uo_units": "UO_0000187", "upper_value": null, "value": "1.3"}, {"action_type": null, "activity_comment": null, "activity_id": 13890964, "activity_properties": [], "assay_chembl_id": "CHEMBL3110978", "assay_description": "Antidiabetic activity in Sprague-Dawley rat assessed as increase of plasma insulin level at 25 nmol/kg, ip administered 0.5 hrs prior to glucose challenge measured for 120 mins by ELISA", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000375", "bao_format": "BAO_0000218", "bao_label": "organism-based format", "canonical_smiles": "CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)C(C)C)[C@@H](C)CC)C(=O)O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL3108706", "document_journal": "J Med Chem", "document_year": 2013, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL4084119", "molecule_pref_name": "LIRAGLUTIDE", "parent_molecule_chembl_id": "CHEMBL4084119", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": null, "record_id": 1963099, "relation": null, "src_id": 1, "standard_flag": 0, "standard_relation": null, "standard_text_value": "Active", "standard_type": "Activity", "standard_units": null, "standard_upper_value": null, "standard_value": null, "target_chembl_id": "CHEMBL376", "target_organism": "Rattus norvegicus", "target_pref_name": "Rattus norvegicus", "target_tax_id": "10116", "text_value": "Active", "toid": null, "type": "Activity", "units": null, "uo_units": null, "upper_value": null, "value": null}, {"action_type": null, "activity_comment": null, "activity_id": 13890965, "activity_properties": [], "assay_chembl_id": "CHEMBL3110977", "assay_description": "Antidiabetic activity in Sprague-Dawley rat assessed as reduction of plasma glucose level at 25 nmol/kg, ip administered 0.5 hrs prior to glucose challenge measured at 15 to 60 mins by OGTT", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000375", "bao_format": "BAO_0000218", "bao_label": "organism-based format", "canonical_smiles": "CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)C(C)C)[C@@H](C)CC)C(=O)O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL3108706", "document_journal": "J Med Chem", "document_year": 2013, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL4084119", "molecule_pref_name": "LIRAGLUTIDE", "parent_molecule_chembl_id": "CHEMBL4084119", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": null, "record_id": 1963099, "relation": null, "src_id": 1, "standard_flag": 0, "standard_relation": null, "standard_text_value": "Active", "standard_type": "Activity", "standard_units": null, "standard_upper_value": null, "standard_value": null, "target_chembl_id": "CHEMBL376", "target_organism": "Rattus norvegicus", "target_pref_name": "Rattus norvegicus", "target_tax_id": "10116", "text_value": "Active", "toid": null, "type": "Activity", "units": null, "uo_units": null, "upper_value": null, "value": null}, {"action_type": null, "activity_comment": null, "activity_id": 13890969, "activity_properties": [], "assay_chembl_id": "CHEMBL3112061", "assay_description": "Antidiabetic activity in C57BL/6J-m+/+Leprdb (db/db) mouse assessed as reduction of blood glucose level at 25 nmol/kg, ip qd administered for 49 days followed by glucose challenge on day 52 measured after 120 mins post glucose challenge by IPGTT", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000375", "bao_format": "BAO_0000218", "bao_label": "organism-based format", "canonical_smiles": "CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)C(C)C)[C@@H](C)CC)C(=O)O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL3108706", "document_journal": "J Med Chem", "document_year": 2013, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL4084119", "molecule_pref_name": "LIRAGLUTIDE", "parent_molecule_chembl_id": "CHEMBL4084119", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": null, "record_id": 1963099, "relation": null, "src_id": 1, "standard_flag": 0, "standard_relation": null, "standard_text_value": "Not active", "standard_type": "Activity", "standard_units": null, "standard_upper_value": null, "standard_value": null, "target_chembl_id": "CHEMBL375", "target_organism": "Mus musculus", "target_pref_name": "Mus musculus", "target_tax_id": "10090", "text_value": "Not Active", "toid": null, "type": "Activity", "units": null, "uo_units": null, "upper_value": null, "value": null}, {"action_type": null, "activity_comment": null, "activity_id": 13890972, "activity_properties": [], "assay_chembl_id": "CHEMBL3112063", "assay_description": "Antidiabetic activity in C57BL/6J-m+/+Leprdb (db/db) mouse assessed as reduction of blood glucose level at 25 nmol/kg, ip qd administered for 49 days followed by glucose challenge on day 52 measured up to 90 mins post glucose challenge by IPGTT", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000375", "bao_format": "BAO_0000218", "bao_label": "organism-based format", "canonical_smiles": "CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)C(C)C)[C@@H](C)CC)C(=O)O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL3108706", "document_journal": "J Med Chem", "document_year": 2013, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL4084119", "molecule_pref_name": "LIRAGLUTIDE", "parent_molecule_chembl_id": "CHEMBL4084119", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": null, "record_id": 1963099, "relation": null, "src_id": 1, "standard_flag": 0, "standard_relation": null, "standard_text_value": "Active", "standard_type": "Activity", "standard_units": null, "standard_upper_value": null, "standard_value": null, "target_chembl_id": "CHEMBL375", "target_organism": "Mus musculus", "target_pref_name": "Mus musculus", "target_tax_id": "10090", "text_value": "Active", "toid": null, "type": "Activity", "units": null, "uo_units": null, "upper_value": null, "value": null}, {"action_type": null, "activity_comment": null, "activity_id": 13890975, "activity_properties": [], "assay_chembl_id": "CHEMBL3112065", "assay_description": "Antidiabetic activity in C57BL/6J-m+/+Leprdb (db/db) mouse assessed as reduction of HbA1c level at 25 to 50 nmol/kg, ip qd measured after 5 weeks", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000375", "bao_format": "BAO_0000218", "bao_label": "organism-based format", "canonical_smiles": "CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)C(C)C)[C@@H](C)CC)C(=O)O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL3108706", "document_journal": "J Med Chem", "document_year": 2013, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL4084119", "molecule_pref_name": "LIRAGLUTIDE", "parent_molecule_chembl_id": "CHEMBL4084119", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": null, "record_id": 1963099, "relation": null, "src_id": 1, "standard_flag": 0, "standard_relation": null, "standard_text_value": "Active", "standard_type": "Activity", "standard_units": null, "standard_upper_value": null, "standard_value": null, "target_chembl_id": "CHEMBL375", "target_organism": "Mus musculus", "target_pref_name": "Mus musculus", "target_tax_id": "10090", "text_value": "Active", "toid": null, "type": "Activity", "units": null, "uo_units": null, "upper_value": null, "value": null}, {"action_type": null, "activity_comment": null, "activity_id": 13890992, "activity_properties": [], "assay_chembl_id": "CHEMBL3110831", "assay_description": "Antidiabetic activity in C57BL/6J-m+/+Leprdb (db/db) mouse assessed as reduction of blood glucose AUC (0 to 48 hrs) at 25 nmol/kg, ip administered for 0.5 hrs", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000375", "bao_format": "BAO_0000218", "bao_label": "organism-based format", "canonical_smiles": "CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)C(C)C)[C@@H](C)CC)C(=O)O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL3108706", "document_journal": "J Med Chem", "document_year": 2013, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL4084119", "molecule_pref_name": "LIRAGLUTIDE", "parent_molecule_chembl_id": "CHEMBL4084119", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": null, "record_id": 1963099, "relation": null, "src_id": 1, "standard_flag": 0, "standard_relation": null, "standard_text_value": "Active", "standard_type": "Activity", "standard_units": null, "standard_upper_value": null, "standard_value": null, "target_chembl_id": "CHEMBL375", "target_organism": "Mus musculus", "target_pref_name": "Mus musculus", "target_tax_id": "10090", "text_value": "Active", "toid": null, "type": "Activity", "units": null, "uo_units": null, "upper_value": null, "value": null}, {"action_type": null, "activity_comment": null, "activity_id": 13890997, "activity_properties": [], "assay_chembl_id": "CHEMBL3110833", "assay_description": "Hypoglycemic activity in C57BL/6J-m+/+Leprdb (db/db) mouse assessed as time required to reduce plasma glucose level below 8.35 mM at 25 nmol/kg, ip administered for 0.5 hrs", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000179", "bao_format": "BAO_0000218", "bao_label": "organism-based format", "canonical_smiles": "CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)C(C)C)[C@@H](C)CC)C(=O)O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL3108706", "document_journal": "J Med Chem", "document_year": 2013, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL4084119", "molecule_pref_name": "LIRAGLUTIDE", "parent_molecule_chembl_id": "CHEMBL4084119", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://qudt.org/vocab/unit#Hour", "record_id": 1963099, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "TIME", "standard_units": "hr", "standard_upper_value": null, "standard_value": "19.0", "target_chembl_id": "CHEMBL375", "target_organism": "Mus musculus", "target_pref_name": "Mus musculus", "target_tax_id": "10090", "text_value": null, "toid": null, "type": "Time", "units": "hr", "uo_units": "UO_0000032", "upper_value": null, "value": "19.0"}, {"action_type": null, "activity_comment": null, "activity_id": 13891001, "activity_properties": [], "assay_chembl_id": "CHEMBL3110834", "assay_description": "Hypoglycemic activity in C57BL/6J-m+/+Leprdb (db/db) mouse assessed as reduction of plasma glucose level at 25 nmol/kg, ip administered 0.5 hrs prior to glucose challenge measured at 18 to 24 hrs by IPGTT", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000375", "bao_format": "BAO_0000218", "bao_label": "organism-based format", "canonical_smiles": "CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)C(C)C)[C@@H](C)CC)C(=O)O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL3108706", "document_journal": "J Med Chem", "document_year": 2013, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL4084119", "molecule_pref_name": "LIRAGLUTIDE", "parent_molecule_chembl_id": "CHEMBL4084119", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": null, "record_id": 1963099, "relation": null, "src_id": 1, "standard_flag": 0, "standard_relation": null, "standard_text_value": "Active", "standard_type": "Activity", "standard_units": null, "standard_upper_value": null, "standard_value": null, "target_chembl_id": "CHEMBL375", "target_organism": "Mus musculus", "target_pref_name": "Mus musculus", "target_tax_id": "10090", "text_value": "Active", "toid": null, "type": "Activity", "units": null, "uo_units": null, "upper_value": null, "value": null}, {"action_type": null, "activity_comment": null, "activity_id": 13891010, "activity_properties": [], "assay_chembl_id": "CHEMBL3110839", "assay_description": "Hypoglycemic activity in C57BL/6J-m+/+Leprdb (db/db) mouse assessed as reduction of plasma glucose level at 25 nmol/kg, ip administered 0.5 hrs prior to glucose challenge measured up to 3 hrs by IPGTT", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000375", "bao_format": "BAO_0000218", "bao_label": "organism-based format", "canonical_smiles": "CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)C(C)C)[C@@H](C)CC)C(=O)O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL3108706", "document_journal": "J Med Chem", "document_year": 2013, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL4084119", "molecule_pref_name": "LIRAGLUTIDE", "parent_molecule_chembl_id": "CHEMBL4084119", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": null, "record_id": 1963099, "relation": null, "src_id": 1, "standard_flag": 0, "standard_relation": null, "standard_text_value": "Not active", "standard_type": "Activity", "standard_units": null, "standard_upper_value": null, "standard_value": null, "target_chembl_id": "CHEMBL375", "target_organism": "Mus musculus", "target_pref_name": "Mus musculus", "target_tax_id": "10090", "text_value": "Not Active", "toid": null, "type": "Activity", "units": null, "uo_units": null, "upper_value": null, "value": null}, {"action_type": null, "activity_comment": null, "activity_id": 13891011, "activity_properties": [], "assay_chembl_id": "CHEMBL3110969", "assay_description": "Hypoglycemic activity in C57BL/6J-m+/+Leprdb (db/db) mouse assessed as reduction of plasma glucose level at 25 nmol/kg, ip administered 0.5 hrs prior to glucose challenge measured after 3 to 17 hrs by IPGTT", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000375", "bao_format": "BAO_0000218", "bao_label": "organism-based format", "canonical_smiles": "CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)C(C)C)[C@@H](C)CC)C(=O)O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL3108706", "document_journal": "J Med Chem", "document_year": 2013, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL4084119", "molecule_pref_name": "LIRAGLUTIDE", "parent_molecule_chembl_id": "CHEMBL4084119", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": null, "record_id": 1963099, "relation": null, "src_id": 1, "standard_flag": 0, "standard_relation": null, "standard_text_value": "Active", "standard_type": "Activity", "standard_units": null, "standard_upper_value": null, "standard_value": null, "target_chembl_id": "CHEMBL375", "target_organism": "Mus musculus", "target_pref_name": "Mus musculus", "target_tax_id": "10090", "text_value": "Active", "toid": null, "type": "Activity", "units": null, "uo_units": null, "upper_value": null, "value": null}, {"action_type": null, "activity_comment": null, "activity_id": 13891014, "activity_properties": [], "assay_chembl_id": "CHEMBL3110972", "assay_description": "Mean residence time in Sprague-Dawley rat at 15 nmol/kg, sc by LC-MS/MS analysis", "assay_type": "A", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000179", "bao_format": "BAO_0000218", "bao_label": "organism-based format", "canonical_smiles": "CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)C(C)C)[C@@H](C)CC)C(=O)O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL3108706", "document_journal": "J Med Chem", "document_year": 2013, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL4084119", "molecule_pref_name": "LIRAGLUTIDE", "parent_molecule_chembl_id": "CHEMBL4084119", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://qudt.org/vocab/unit#Hour", "record_id": 1963099, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "MRT", "standard_units": "hr", "standard_upper_value": null, "standard_value": "18.34", "target_chembl_id": "CHEMBL376", "target_organism": "Rattus norvegicus", "target_pref_name": "Rattus norvegicus", "target_tax_id": "10116", "text_value": null, "toid": null, "type": "MRT", "units": "hr", "uo_units": "UO_0000032", "upper_value": null, "value": "18.34"}, {"action_type": null, "activity_comment": null, "activity_id": 13891018, "activity_properties": [], "assay_chembl_id": "CHEMBL3110973", "assay_description": "Elimination half life in Sprague-Dawley rat at 15 nmol/kg, sc by LC-MS/MS analysis", "assay_type": "A", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0002115", "bao_format": "BAO_0000218", "bao_label": "organism-based format", "canonical_smiles": "CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)C(C)C)[C@@H](C)CC)C(=O)O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL3108706", "document_journal": "J Med Chem", "document_year": 2013, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL4084119", "molecule_pref_name": "LIRAGLUTIDE", "parent_molecule_chembl_id": "CHEMBL4084119", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://qudt.org/vocab/unit#Hour", "record_id": 1963099, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "T1/2", "standard_units": "hr", "standard_upper_value": null, "standard_value": "12.54", "target_chembl_id": "CHEMBL376", "target_organism": "Rattus norvegicus", "target_pref_name": "Rattus norvegicus", "target_tax_id": "10116", "text_value": null, "toid": null, "type": "beta t1/2", "units": "hr", "uo_units": "UO_0000032", "upper_value": null, "value": "12.54"}], "page_meta": {"limit": 20, "next": "/chembl/api/data/activity.json?limit=20&offset=20&molecule_chembl_id=CHEMBL4084119", "offset": 0, "previous": null, "total_count": 125}}