{"activities": [{"action_type": null, "activity_comment": null, "activity_id": 18132005, "activity_properties": [], "assay_chembl_id": "CHEMBL4029349", "assay_description": "Liver toxicity in human assessed as induction of drug-induced liver injury by measuring severity class index", "assay_type": "T", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000179", "bao_format": "BAO_0000019", "bao_label": "assay format", "canonical_smiles": "C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC[C@@H](C(=O)N[C@H](CO)[C@@H](C)O)NC1=O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL4028802", "document_journal": "Drug Discov Today", "document_year": 2016, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL1680", "molecule_pref_name": "OCTREOTIDE", "parent_molecule_chembl_id": "CHEMBL1680", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": null, "record_id": 3007003, "relation": "=", "src_id": 1, "standard_flag": 0, "standard_relation": "=", "standard_text_value": null, "standard_type": "DILI_severity_class", "standard_units": null, "standard_upper_value": null, "standard_value": "2.0", "target_chembl_id": "CHEMBL372", "target_organism": "Homo sapiens", "target_pref_name": "Homo sapiens", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "DILI_severity_class", "units": null, "uo_units": null, "upper_value": null, "value": "2.0"}, {"action_type": null, "activity_comment": null, "activity_id": 18132605, "activity_properties": [], "assay_chembl_id": "CHEMBL4029350", "assay_description": "Liver toxicity in human assessed as induction of drug-induced liver injury by measuring verified drug-induced liver injury concern status", "assay_type": "T", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000179", "bao_format": "BAO_0000019", "bao_label": "assay format", "canonical_smiles": "C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC[C@@H](C(=O)N[C@H](CO)[C@@H](C)O)NC1=O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL4028802", "document_journal": "Drug Discov Today", "document_year": 2016, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL1680", "molecule_pref_name": "OCTREOTIDE", "parent_molecule_chembl_id": "CHEMBL1680", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": null, "record_id": 3007003, "relation": null, "src_id": 1, "standard_flag": 0, "standard_relation": null, "standard_text_value": "Less-Dili-Concern", "standard_type": "DILI_Concern", "standard_units": null, "standard_upper_value": null, "standard_value": null, "target_chembl_id": "CHEMBL372", "target_organism": "Homo sapiens", "target_pref_name": "Homo sapiens", "target_tax_id": "9606", "text_value": "Less-Dili-Concern", "toid": null, "type": "DILI_Concern", "units": null, "uo_units": null, "upper_value": null, "value": null}, {"action_type": null, "activity_comment": null, "activity_id": 18534617, "activity_properties": [], "assay_chembl_id": "CHEMBL4195969", "assay_description": "Agonist activity at SSTR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-induced CRE promoter activity at 10 to 1000 nM by luciferase reporter gene assay", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000201", "bao_format": "BAO_0000219", "bao_label": "cell-based format", "canonical_smiles": "C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC[C@@H](C(=O)N[C@H](CO)[C@@H](C)O)NC1=O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL4190409", "document_journal": "Bioorg Med Chem", "document_year": 2018, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL1680", "molecule_pref_name": "OCTREOTIDE", "parent_molecule_chembl_id": "CHEMBL1680", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://qudt.org/vocab/unit#Percent", "record_id": 3077309, "relation": null, "src_id": 1, "standard_flag": 0, "standard_relation": null, "standard_text_value": "Active", "standard_type": "Inhibition", "standard_units": "%", "standard_upper_value": null, "standard_value": null, "target_chembl_id": "CHEMBL1804", "target_organism": "Homo sapiens", "target_pref_name": "Somatostatin receptor type 2", "target_tax_id": "9606", "text_value": "Active", "toid": null, "type": "INH", "units": null, "uo_units": "UO_0000187", "upper_value": null, "value": null}, {"action_type": null, "activity_comment": null, "activity_id": 18534621, "activity_properties": [], "assay_chembl_id": "CHEMBL4195970", "assay_description": "Agonist activity at SSTR3 (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-induced CRE promoter activity at 10 to 1000 nM by luciferase reporter gene assay", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000201", "bao_format": "BAO_0000219", "bao_label": "cell-based format", "canonical_smiles": "C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC[C@@H](C(=O)N[C@H](CO)[C@@H](C)O)NC1=O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL4190409", "document_journal": "Bioorg Med Chem", "document_year": 2018, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL1680", "molecule_pref_name": "OCTREOTIDE", "parent_molecule_chembl_id": "CHEMBL1680", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://qudt.org/vocab/unit#Percent", "record_id": 3077309, "relation": null, "src_id": 1, "standard_flag": 0, "standard_relation": null, "standard_text_value": "Active", "standard_type": "Inhibition", "standard_units": "%", "standard_upper_value": null, "standard_value": null, "target_chembl_id": "CHEMBL2028", "target_organism": "Homo sapiens", "target_pref_name": "Somatostatin receptor type 3", "target_tax_id": "9606", "text_value": "Active", "toid": null, "type": "INH", "units": null, "uo_units": "UO_0000187", "upper_value": null, "value": null}, {"action_type": null, "activity_comment": null, "activity_id": 18534628, "activity_properties": [], "assay_chembl_id": "CHEMBL4195972", "assay_description": "Agonist activity at SSTR5 (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-induced CRE promoter activity at 10 to 1000 nM by luciferase reporter gene assay", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000201", "bao_format": "BAO_0000219", "bao_label": "cell-based format", "canonical_smiles": "C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC[C@@H](C(=O)N[C@H](CO)[C@@H](C)O)NC1=O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL4190409", "document_journal": "Bioorg Med Chem", "document_year": 2018, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL1680", "molecule_pref_name": "OCTREOTIDE", "parent_molecule_chembl_id": "CHEMBL1680", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://qudt.org/vocab/unit#Percent", "record_id": 3077309, "relation": null, "src_id": 1, "standard_flag": 0, "standard_relation": null, "standard_text_value": "Active", "standard_type": "Inhibition", "standard_units": "%", "standard_upper_value": null, "standard_value": null, "target_chembl_id": "CHEMBL1792", "target_organism": "Homo sapiens", "target_pref_name": "Somatostatin receptor type 5", "target_tax_id": "9606", "text_value": "Active", "toid": null, "type": "INH", "units": null, "uo_units": "UO_0000187", "upper_value": null, "value": null}, {"action_type": null, "activity_comment": null, "activity_id": 18948297, "activity_properties": [], "assay_chembl_id": "CHEMBL4330499", "assay_description": "Inhibition of human SSTR5 by radioligand binding assay", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000190", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC[C@@H](C(=O)N[C@H](CO)[C@@H](C)O)NC1=O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL4330062", "document_journal": "Eur J Med Chem", "document_year": 2019, "ligand_efficiency": {"bei": "7.51", "le": null, "lle": null, "sei": null}, "modality": null, "molecule_chembl_id": "CHEMBL1680", "molecule_pref_name": "OCTREOTIDE", "parent_molecule_chembl_id": "CHEMBL1680", "pchembl_value": "7.66", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 3161075, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "IC50", "standard_units": "nM", "standard_upper_value": null, "standard_value": "22.0", "target_chembl_id": "CHEMBL1792", "target_organism": "Homo sapiens", "target_pref_name": "Somatostatin receptor type 5", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "IC50", "units": "nM", "uo_units": "UO_0000065", "upper_value": null, "value": "22.0"}, {"action_type": null, "activity_comment": null, "activity_id": 18948301, "activity_properties": [], "assay_chembl_id": "CHEMBL4330498", "assay_description": "Inhibition of human SSTR4 by radioligand binding assay", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000190", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC[C@@H](C(=O)N[C@H](CO)[C@@H](C)O)NC1=O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL4330062", "document_journal": "Eur J Med Chem", "document_year": 2019, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL1680", "molecule_pref_name": "OCTREOTIDE", "parent_molecule_chembl_id": "CHEMBL1680", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 3161075, "relation": ">", "src_id": 1, "standard_flag": 1, "standard_relation": ">", "standard_text_value": null, "standard_type": "IC50", "standard_units": "nM", "standard_upper_value": null, "standard_value": "1000.0", "target_chembl_id": "CHEMBL1853", "target_organism": "Homo sapiens", "target_pref_name": "Somatostatin receptor type 4", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "IC50", "units": "nM", "uo_units": "UO_0000065", "upper_value": null, "value": "1000.0"}, {"action_type": null, "activity_comment": null, "activity_id": 19104069, "activity_properties": [], "assay_chembl_id": "CHEMBL4369219", "assay_description": "Binding affinity to human SST2 receptor", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000192", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC[C@@H](C(=O)N[C@H](CO)[C@@H](C)O)NC1=O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL4368866", "document_journal": "Medchemcomm", "document_year": 2018, "ligand_efficiency": {"bei": "9.22", "le": null, "lle": null, "sei": null}, "modality": null, "molecule_chembl_id": "CHEMBL1680", "molecule_pref_name": "OCTREOTIDE", "parent_molecule_chembl_id": "CHEMBL1680", "pchembl_value": "9.40", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 3187461, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "Ki", "standard_units": "nM", "standard_upper_value": null, "standard_value": "0.4", "target_chembl_id": "CHEMBL1804", "target_organism": "Homo sapiens", "target_pref_name": "Somatostatin receptor type 2", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "Ki", "units": "nM", "uo_units": "UO_0000065", "upper_value": "2.1", "value": "0.4"}, {"action_type": null, "activity_comment": null, "activity_id": 19104070, "activity_properties": [], "assay_chembl_id": "CHEMBL4369218", "assay_description": "Binding affinity to human SST4 receptor", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000192", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC[C@@H](C(=O)N[C@H](CO)[C@@H](C)O)NC1=O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL4368866", "document_journal": "Medchemcomm", "document_year": 2018, "ligand_efficiency": {"bei": "7.04", "le": null, "lle": null, "sei": null}, "modality": null, "molecule_chembl_id": "CHEMBL1680", "molecule_pref_name": "OCTREOTIDE", "parent_molecule_chembl_id": "CHEMBL1680", "pchembl_value": "7.18", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 3187461, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "Ki", "standard_units": "nM", "standard_upper_value": null, "standard_value": "66.0", "target_chembl_id": "CHEMBL1853", "target_organism": "Homo sapiens", "target_pref_name": "Somatostatin receptor type 4", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "Ki", "units": "nM", "uo_units": "UO_0000065", "upper_value": "2100.0", "value": "66.0"}, {"action_type": {"action_type": "AGONIST", "description": "Binds to and activates a receptor, often mimicking the effect of the endogenous ligand", "parent_type": "POSITIVE MODULATOR"}, "activity_comment": null, "activity_id": 23298623, "activity_properties": [{"comments": null, "relation": "=", "result_flag": 0, "standard_relation": "=", "standard_text_value": null, "standard_type": "TIME", "standard_units": "hr", "standard_value": "0.5", "text_value": null, "type": "Time", "units": "min", "value": "30.0"}], "assay_chembl_id": "CHEMBL4841562", "assay_description": "Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000188", "bao_format": "BAO_0000219", "bao_label": "cell-based format", "canonical_smiles": "C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC[C@@H](C(=O)N[C@H](CO)[C@@H](C)O)NC1=O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL4840347", "document_journal": "Bioorg Med Chem", "document_year": 2021, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL1680", "molecule_pref_name": "OCTREOTIDE", "parent_molecule_chembl_id": "CHEMBL1680", "pchembl_value": "10.52", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 3625723, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "EC50", "standard_units": "nM", "standard_upper_value": null, "standard_value": "0.03", "target_chembl_id": "CHEMBL1804", "target_organism": "Homo sapiens", "target_pref_name": "Somatostatin receptor type 2", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "EC50", "units": "nmol/L", "uo_units": "UO_0000065", "upper_value": null, "value": "0.03"}, {"action_type": null, "activity_comment": null, "activity_id": 24816246, "activity_properties": [{"comments": null, "relation": "<=", "result_flag": 0, "standard_relation": "<=", "standard_text_value": null, "standard_type": "TIME", "standard_units": "hr", "standard_value": "24.0", "text_value": null, "type": "Time", "units": "hrs", "value": "24.0"}], "assay_chembl_id": "CHEMBL5138696", "assay_description": "Stability of the compound in simulated gastric fluid at pH 1.2 assessed as half life measured up to 24 hrs by RP-HPLC-UV analysis", "assay_type": "A", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0002115", "bao_format": "BAO_0000019", "bao_label": "assay format", "canonical_smiles": "C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC[C@@H](C(=O)N[C@H](CO)[C@@H](C)O)NC1=O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL5137009", "document_journal": "J Med Chem", "document_year": 2022, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL1680", "molecule_pref_name": "OCTREOTIDE", "parent_molecule_chembl_id": "CHEMBL1680", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://qudt.org/vocab/unit#Hour", "record_id": 3875242, "relation": ">", "src_id": 1, "standard_flag": 1, "standard_relation": ">", "standard_text_value": null, "standard_type": "T1/2", "standard_units": "hr", "standard_upper_value": null, "standard_value": "24.0", "target_chembl_id": "CHEMBL612558", "target_organism": null, "target_pref_name": "ADMET", "target_tax_id": null, "text_value": null, "toid": null, "type": "t1/2", "units": "hr", "uo_units": "UO_0000032", "upper_value": null, "value": "24.0"}, {"action_type": null, "activity_comment": null, "activity_id": 24816261, "activity_properties": [{"comments": null, "relation": "<=", "result_flag": 0, "standard_relation": "<=", "standard_text_value": null, "standard_type": "TIME", "standard_units": "hr", "standard_value": "24.0", "text_value": null, "type": "Time", "units": "hrs", "value": "24.0"}], "assay_chembl_id": "CHEMBL5138697", "assay_description": "Stability of the compound in simulated intestinal fluid at pH 6.8 assessed as half life measured up to 24 hrs by RP-HPLC-UV analysis", "assay_type": "A", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0002115", "bao_format": "BAO_0000019", "bao_label": "assay format", "canonical_smiles": "C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC[C@@H](C(=O)N[C@H](CO)[C@@H](C)O)NC1=O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL5137009", "document_journal": "J Med Chem", "document_year": 2022, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL1680", "molecule_pref_name": "OCTREOTIDE", "parent_molecule_chembl_id": "CHEMBL1680", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://qudt.org/vocab/unit#Hour", "record_id": 3875242, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "T1/2", "standard_units": "hr", "standard_upper_value": null, "standard_value": "8.3", "target_chembl_id": "CHEMBL612558", "target_organism": null, "target_pref_name": "ADMET", "target_tax_id": null, "text_value": null, "toid": null, "type": "t1/2", "units": "hr", "uo_units": "UO_0000032", "upper_value": null, "value": "8.3"}, {"action_type": null, "activity_comment": null, "activity_id": 26241696, "activity_properties": [], "assay_chembl_id": "CHEMBL5665199", "assay_description": "Agonist activity at N-terminal Flag-tagged human MRGPRX2 receptor expressed in tetracycline-induced FLP-IN/T-REX 293 cells assessed as increase in intracellular calcium release by FLIPR assay", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000188", "bao_format": "BAO_0000219", "bao_label": "cell-based format", "canonical_smiles": "C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC[C@@H](C(=O)N[C@H](CO)[C@@H](C)O)NC1=O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL5661985", "document_journal": "Nat Chem Biol", "document_year": 2017, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL1680", "molecule_pref_name": "OCTREOTIDE", "parent_molecule_chembl_id": "CHEMBL1680", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 4137454, "relation": "<", "src_id": 72, "standard_flag": 1, "standard_relation": ">", "standard_text_value": null, "standard_type": "EC50", "standard_units": "nM", "standard_upper_value": null, "standard_value": "31622.78", "target_chembl_id": "CHEMBL5849", "target_organism": "Homo sapiens", "target_pref_name": "Mas-related G-protein coupled receptor member X2", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "pEC50", "units": null, "uo_units": "UO_0000065", "upper_value": null, "value": "4.5"}, {"action_type": null, "activity_comment": null, "activity_id": 26241717, "activity_properties": [{"comments": null, "relation": "<=", "result_flag": 0, "standard_relation": "<=", "standard_text_value": null, "standard_type": "DOSE", "standard_units": "microM", "standard_value": "100.0", "text_value": null, "type": "DOSE", "units": "microM", "value": "100.0"}], "assay_chembl_id": "CHEMBL5665200", "assay_description": "Agonist activity at N-terminal Flag-tagged human MRGPRX2 receptor expressed in tetracycline-induced FLP-IN/T-REX 293 cells assessed as increase in intracellular calcium release up to 100 uM by FLIPR assay", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000375", "bao_format": "BAO_0000219", "bao_label": "cell-based format", "canonical_smiles": "C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC[C@@H](C(=O)N[C@H](CO)[C@@H](C)O)NC1=O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL5661985", "document_journal": "Nat Chem Biol", "document_year": 2017, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL1680", "molecule_pref_name": "OCTREOTIDE", "parent_molecule_chembl_id": "CHEMBL1680", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": null, "record_id": 4137454, "relation": null, "src_id": 72, "standard_flag": 0, "standard_relation": null, "standard_text_value": "Not active", "standard_type": "Activity", "standard_units": null, "standard_upper_value": null, "standard_value": null, "target_chembl_id": "CHEMBL5849", "target_organism": "Homo sapiens", "target_pref_name": "Mas-related G-protein coupled receptor member X2", "target_tax_id": "9606", "text_value": "Not Active", "toid": null, "type": "Activity", "units": null, "uo_units": null, "upper_value": null, "value": null}, {"action_type": null, "activity_comment": null, "activity_id": 26241812, "activity_properties": [{"comments": null, "relation": "=", "result_flag": 0, "standard_relation": "=", "standard_text_value": null, "standard_type": "TIME_Lower", "standard_units": "hrs", "standard_value": "18.0", "text_value": null, "type": "TIME_Lower", "units": "hrs", "value": "18.0"}, {"comments": null, "relation": "=", "result_flag": 0, "standard_relation": "=", "standard_text_value": null, "standard_type": "TIME_Upper", "standard_units": "hrs", "standard_value": "24.0", "text_value": null, "type": "TIME_Upper", "units": "hrs", "value": "24.0"}], "assay_chembl_id": "CHEMBL5665202", "assay_description": "Agonist activity at MRGPRX2 (unknown origin) expressed in HTLA cells assessed as induction of beta-arrestin 2 recruitment incubated for 18 to 24 hrs by PRESTO-Tango assay", "assay_type": "F", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000188", "bao_format": "BAO_0000219", "bao_label": "cell-based format", "canonical_smiles": "C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC[C@@H](C(=O)N[C@H](CO)[C@@H](C)O)NC1=O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL5661985", "document_journal": "Nat Chem Biol", "document_year": 2017, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL1680", "molecule_pref_name": "OCTREOTIDE", "parent_molecule_chembl_id": "CHEMBL1680", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 4137454, "relation": "<", "src_id": 72, "standard_flag": 1, "standard_relation": ">", "standard_text_value": null, "standard_type": "EC50", "standard_units": "nM", "standard_upper_value": null, "standard_value": "31622.78", "target_chembl_id": "CHEMBL5849", "target_organism": "Homo sapiens", "target_pref_name": "Mas-related G-protein coupled receptor member X2", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "pEC50", "units": null, "uo_units": "UO_0000065", "upper_value": null, "value": "4.5"}, {"action_type": null, "activity_comment": null, "activity_id": 29103801, "activity_properties": [], "assay_chembl_id": "CHEMBL6086416", "assay_description": "Half life in human plasma", "assay_type": "A", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0002115", "bao_format": "BAO_0000366", "bao_label": "cell-free format", "canonical_smiles": "C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC[C@@H](C(=O)N[C@H](CO)[C@@H](C)O)NC1=O", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL6083278", "document_journal": "J Med Chem", "document_year": 2024, "ligand_efficiency": null, "modality": null, "molecule_chembl_id": "CHEMBL1680", "molecule_pref_name": "OCTREOTIDE", "parent_molecule_chembl_id": "CHEMBL1680", "pchembl_value": null, "potential_duplicate": 0, "qudt_units": "http://qudt.org/vocab/unit#Hour", "record_id": 4668585, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "T1/2", "standard_units": "hr", "standard_upper_value": null, "standard_value": "1.5", "target_chembl_id": "CHEMBL612558", "target_organism": null, "target_pref_name": "ADMET", "target_tax_id": null, "text_value": null, "toid": null, "type": "t1/2", "units": "hr", "uo_units": "UO_0000032", "upper_value": null, "value": "1.5"}], "page_meta": {"limit": 20, "next": null, "offset": 0, "previous": null, "total_count": 16}}