CHEBI:9544 - thiethylperazine

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ChEBI Name thiethylperazine
ChEBI ID CHEBI:9544
Definition A member of the class of phenothiazines that is perazine substituted by a ethylsulfanyl group at position 2.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C22H29N3S2
Net Charge 0
Average Mass 399.61788
Monoisotopic Mass 399.180
InChI InChI=1S/C22H29N3S2/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24/h4-5,7-10,17H,3,6,11-16H2,1-2H3
InChIKey XCTYLCDETUVOIP-UHFFFAOYSA-N
SMILES CCSc1ccc2Sc3ccccc3N(CCCN3CCN(C)CC3)c2c1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): histamine antagonist
Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
muscarinic antagonist
A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
Application(s): phenothiazine antipsychotic drug

histamine antagonist
Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
muscarinic antagonist
A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
antiemetic
A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing thiethylperazine (CHEBI:9544) has functional parent perazine (CHEBI:59118)
thiethylperazine (CHEBI:9544) has role antiemetic (CHEBI:50919)
thiethylperazine (CHEBI:9544) has role dopaminergic antagonist (CHEBI:48561)
thiethylperazine (CHEBI:9544) has role histamine antagonist (CHEBI:37956)
thiethylperazine (CHEBI:9544) has role muscarinic antagonist (CHEBI:48876)
thiethylperazine (CHEBI:9544) has role phenothiazine antipsychotic drug (CHEBI:37930)
thiethylperazine (CHEBI:9544) has role serotonergic antagonist (CHEBI:48279)
thiethylperazine (CHEBI:9544) is a N-methylpiperazine (CHEBI:46920)
thiethylperazine (CHEBI:9544) is a phenothiazines (CHEBI:38093)
Incoming thiethylperazine maleate (CHEBI:32216) has part thiethylperazine (CHEBI:9544)
IUPAC Name
2-(ethylsulfanyl)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
INNs Sources
thiéthylpérazine ChEBI
thiethylperazine ChEBI
thiethylperazinum ChEBI
tietilperazina ChEBI
Synonyms Sources
2-(ethylthio)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine ChEBI
3-Ethylmercapto-10-(1'-methylpiperazinyl-4'-propyl)phenothiazine ChemIDplus
Ethylthioperazine KEGG COMPOUND
Thiethylperazine KEGG COMPOUND
Manual Xrefs Databases
2630 DrugCentral
C07132 KEGG COMPOUND
D02354 KEGG DRUG
DB00372 DrugBank
HMDB0014516 HMDB
LSM-3556 LINCS
Thiethylperazine Wikipedia
View more database links
Registry Numbers Types Sources
1420-55-9 CAS Registry Number ChemIDplus
52127 Beilstein Registry Number Beilstein
52127 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
15469457 PubMed citation Europe PMC
23243946 PubMed citation Europe PMC
Last Modified
22 February 2017