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LY404039 |
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CHEBI:94640 |
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An organic heterobicyclic compound that is (1S,5R)-2-thiabicyclo[3.1.0]hexane carrying oxo, oxo, amino, carboxy, and carboxy groups at positions 2, 2, 4S, 4S, and 6S, respectively. It is a potent agonist of group II metabotropic glutamate receptors mGluR2 mGluR3 (Ki = 149 nM and 92 nM, respectively) and exhibits antipsychotic and anxiolytic efficacy in animal models. |
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This entity has been manually annotated by the ChEBI Team.
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Molfile
XML
SDF
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InChI=1S/C7H9NO6S/c8-7(6(11)12)1-15(13,14)4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1 |
AVDUGNCTZRCAHH-MDASVERJSA-N |
[H][C@@]12[C@@H](C(O)=O)[C@]1([H])S(=O)(=O)C[C@@]2(N)C(O)=O |
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Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
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metabotropic glutamate receptor agonist
An agonist that selectively binds to and activates a metabotropic glutamate receptor.
dopamine agonist
A drug that binds to and activates dopamine receptors.
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antipsychotic agent
Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect.
anxiolytic drug
Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
dopamine agonist
A drug that binds to and activates dopamine receptors.
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View more via ChEBI Ontology
(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide
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(−)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid
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ChEBI
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(1R,4S,5S,6S)-4-amino-2,2-dioxo-2λ6-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
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IUPAC
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LY 404039
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ChemIDplus
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LY-404,039
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ChEBI
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LY-404039
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ChemIDplus
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LY404039
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ChemIDplus
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pomaglumetad
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ChEBI
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635318-11-5
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CAS Registry Number
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ChemIDplus
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16678921
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PubMed citation
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Europe PMC
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17204749
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PubMed citation
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Europe PMC
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17384937
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PubMed citation
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Europe PMC
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18424625
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PubMed citation
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Europe PMC
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19006848
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PubMed citation
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Europe PMC
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20571979
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PubMed citation
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Europe PMC
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21847569
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PubMed citation
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Europe PMC
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22884896
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PubMed citation
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Europe PMC
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23694720
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PubMed citation
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Europe PMC
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24486391
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PubMed citation
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Europe PMC
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25382826
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PubMed citation
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Europe PMC
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25755052
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PubMed citation
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Europe PMC
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31308026
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PubMed citation
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Europe PMC
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32403118
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PubMed citation
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Europe PMC
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