CHEBI:9445 - terazosin

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ChEBI Name terazosin
ChEBI ID CHEBI:9445
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C19H25N5O4
Net Charge 0
Average Mass 387.43310
Monoisotopic Mass 387.191
InChI InChI=1S/C19H25N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22)
InChIKey VCKUSRYTPJJLNI-UHFFFAOYSA-N
SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
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ChEBI Ontology
Outgoing terazosin (CHEBI:9445) has role α-adrenergic antagonist (CHEBI:37890)
terazosin (CHEBI:9445) has role antihypertensive agent (CHEBI:35674)
terazosin (CHEBI:9445) has role antineoplastic agent (CHEBI:35610)
terazosin (CHEBI:9445) is a furans (CHEBI:24129)
terazosin (CHEBI:9445) is a piperazines (CHEBI:26144)
terazosin (CHEBI:9445) is a primary amino compound (CHEBI:50994)
terazosin (CHEBI:9445) is a quinazolines (CHEBI:38530)
Incoming terazosin hydrochloride dihydrate (CHEBI:9446) has part terazosin (CHEBI:9445)
IUPAC Name
6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine
INNs Sources
terazosin WHO MedNet
terazosina WHO MedNet
térazosine WHO MedNet
terazosinum WHO MedNet
Synonyms Sources
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine ChemIDplus
Terazosin KEGG COMPOUND
Terazosine KEGG COMPOUND
Manual Xrefs Databases
3584 DrugCentral
C07127 KEGG COMPOUND
D08569 KEGG DRUG
DB01162 DrugBank
DE2646186 Patent
DE2831112 Patent
LSM-4997 LINCS
Terazosin Wikipedia
US4026894 Patent
US4251532 Patent
View more database links
Registry Numbers Types Sources
63590-64-7 CAS Registry Number ChemIDplus
719452 Beilstein Registry Number Beilstein
Last Modified
22 February 2017