CHEBI:92211 - SL-327

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ChEBI Name SL-327
Definition A nitrile that is acrylonitrile in which the hydrogen attached to the same carbon as the cyano group has been replaced by an o-(trifluoromethyl)phenyl group, while the remaining hydrogens of the ethenyl group have been replaced by amino and (4-aminophenyl)sulfanyl groups. The configuration of the double bond is not specified. It is an inhibitor of MEK1 and MEK2.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C16H12F3N3S
Net Charge 0
Average Mass 335.348
Monoisotopic Mass 335.070
InChI InChI=1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC (mitogen-activated protein kinase kinase) inhibitor
An EC 2.7.12.* [dual-specificity kinases (those acting on Ser/Thr and Tyr residues)] inhibitor that inhibits the action of mitogen-activated protein kinase kinase (EC
Application(s): neuroprotective agent
Any compound that can be used for the treatment of neurodegenerative disorders.
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ChEBI Ontology
Outgoing SL-327 (CHEBI:92211) has role EC (mitogen-activated protein kinase kinase) inhibitor (CHEBI:88286)
SL-327 (CHEBI:92211) has role neuroprotective agent (CHEBI:63726)
SL-327 (CHEBI:92211) is a (trifluoromethyl)benzenes (CHEBI:83565)
SL-327 (CHEBI:92211) is a enamine (CHEBI:47989)
SL-327 (CHEBI:92211) is a nitrile (CHEBI:18379)
SL-327 (CHEBI:92211) is a organic sulfide (CHEBI:16385)
SL-327 (CHEBI:92211) is a primary amino compound (CHEBI:50994)
SL-327 (CHEBI:92211) is a substituted aniline (CHEBI:48975)
Synonyms Sources
3-amino-3-[(4-aminophenyl)thio]-2-[2-(trifluoromethyl)phenyl]-2-propenenitrile LINCS
α-{amino[(4-aminophenyl)thio]methylene}-2-(trifluoromethyl)benzeneacetonitrile ChemIDplus
SL 327 ChemIDplus
Manual Xref Database
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Registry Numbers Types Sources
305350-87-2 CAS Registry Number ChemIDplus
9423720 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
10969080 PubMed citation Europe PMC
12490588 PubMed citation Europe PMC
18766328 PubMed citation Europe PMC
21074569 PubMed citation Europe PMC
21312031 PubMed citation Europe PMC
Last Modified
04 May 2016