CHEBI:91435 - linifanib

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ChEBI Name linifanib
ChEBI ID CHEBI:91435
Definition A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 2-fluoro-5-methylphenyl group, while the other is substituted by a p-(3-amino-1H-indazol-4-yl)phenyl group. It is a potent, selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinases.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C21H18FN5O
Net Charge 0
Average Mass 375.400
Monoisotopic Mass 375.150
InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
InChIKey MPVGZUGXCQEXTM-UHFFFAOYSA-N
SMILES CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
angiogenesis inhibitor
An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
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ChEBI Ontology
Outgoing linifanib (CHEBI:91435) has role angiogenesis inhibitor (CHEBI:48422)
linifanib (CHEBI:91435) has role antineoplastic agent (CHEBI:35610)
linifanib (CHEBI:91435) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
linifanib (CHEBI:91435) is a aromatic amine (CHEBI:33860)
linifanib (CHEBI:91435) is a indazoles (CHEBI:38769)
linifanib (CHEBI:91435) is a phenylureas (CHEBI:134043)
INNs Sources
linifanib WHO MedNet
linifanib WHO MedNet
linifanib WHO MedNet
linifanibum WHO MedNet
Synonyms Sources
1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea LINCS
ABT 869 ChemIDplus
ABT-869 ChemIDplus
ABT869 ChEBI
N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea ChemIDplus
Manual Xrefs Databases
D09635 KEGG DRUG
Linifanib Wikipedia
LSM-1183 LINCS
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Registry Numbers Types Sources
11008713 Reaxys Registry Number Reaxys
796967-16-3 CAS Registry Number KEGG DRUG
796967-16-3 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
16648571 PubMed citation Europe PMC
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Last Modified
10 December 2016