CHEBI:9137 - sibutramine

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ChEBI Name sibutramine
ChEBI ID CHEBI:9137
Definition A tertiary amino compound that is N,N,3-trimethylbutan-1-amine substituted by a (4-chlorophenyl)cyclobutyl group at position 1.
Stars This entity has been manually annotated by a third party.
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Formula C17H26ClN
Net Charge 0
Average Mass 279.84800
Monoisotopic Mass 279.175
InChI InChI=1S/C17H26ClN/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14/h6-9,13,16H,5,10-12H2,1-4H3
InChIKey UNAANXDKBXWMLN-UHFFFAOYSA-N
SMILES CC(C)CC(N(C)C)C1(CCC1)c1ccc(Cl)cc1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): anti-obesity agent
Any substance which is used to reduce or control weight.
serotonin uptake inhibitor
A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent.
Application(s): serotonin uptake inhibitor
A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent.
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ChEBI Ontology
Outgoing sibutramine (CHEBI:9137) has role anti-obesity agent (CHEBI:74518)
sibutramine (CHEBI:9137) has role serotonin uptake inhibitor (CHEBI:50949)
sibutramine (CHEBI:9137) is a organochlorine compound (CHEBI:36683)
sibutramine (CHEBI:9137) is a tertiary amino compound (CHEBI:50996)
IUPAC Name
1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine
Synonyms Sources
(+/-)-Sibutramine DrugCentral
BTS 54524 DrugCentral
didemethyl sibutramine HCl DrugCentral
didemethyl sibutramine hydrochloride DrugCentral
didesmethylsibutramine DrugCentral
racemic sibutramine DrugCentral
Sibutramine KEGG COMPOUND
sibutramine HCl DrugCentral
sibutramine hydrochloride DrugCentral
sibutramine hydrochloride hydrate DrugCentral
Brand Names Sources
Butramin ChemIDplus
Medaria ChemIDplus
Meridia ChemIDplus
Reductil ChemIDplus
Manual Xrefs Databases
2440 DrugCentral
C07247 KEGG COMPOUND
CN101890017 Patent
CN101897685 Patent
D08513 KEGG DRUG
DB01105 DrugBank
LSM-5000 LINCS
Sibutramine Wikipedia
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Registry Numbers Types Sources
106650-56-0 CAS Registry Number KEGG COMPOUND
106650-56-0 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
22830954 PubMed citation Europe PMC
23406184 PubMed citation Europe PMC
23543553 PubMed citation Europe PMC
23576325 PubMed citation Europe PMC
23625194 PubMed citation Europe PMC
23677499 PubMed citation Europe PMC
23776614 PubMed citation Europe PMC
23777987 PubMed citation Europe PMC
Last Modified
22 February 2017