CHEBI:91088 - orantinib

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ChEBI Name orantinib
Definition An oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is substituted by a 2-(2-carboxyethyl)-3,5-dimethylpyrrol-3-yl group. It is an ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C18H18N2O3
Net Charge 0
Average Mass 310.348
Monoisotopic Mass 310.132
InChI InChI=1S/C18H18N2O3/c1-10-12(7-8-17(21)22)11(2)19-16(10)9-14-13-5-3-4-6-15(13)20-18(14)23/h3-6,9,19H,7-8H2,1-2H3,(H,20,23)(H,21,22)
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): vascular endothelial growth factor receptor antagonist
An antagonist at the vascular endothelial growth factor receptor.
EC (receptor protein-tyrosine kinase) inhibitor
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
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ChEBI Ontology
Outgoing orantinib (CHEBI:91088) has functional parent 3-methyleneoxindole (CHEBI:17920)
orantinib (CHEBI:91088) has role antineoplastic agent (CHEBI:35610)
orantinib (CHEBI:91088) has role EC (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
orantinib (CHEBI:91088) has role vascular endothelial growth factor receptor antagonist (CHEBI:65207)
orantinib (CHEBI:91088) is a monocarboxylic acid (CHEBI:25384)
orantinib (CHEBI:91088) is a oxindoles (CHEBI:38459)
orantinib (CHEBI:91088) is a pyrroles (CHEBI:26455)
3-{2,4-dimethyl-5-[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid
INN Source
orantinib ChemIDplus
Synonyms Sources
3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl)propionic acid ChemIDplus
3-(4-(2-Carboxyethyl)-3,5-dimethylpyrrol-2-methylidenyl)-2-indolinone ChemIDplus
5-((1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-propanoic acid ChemIDplus
SU 6668 ChemIDplus
SU-6668 ChemIDplus
SU6668 ChemIDplus
TSU 68 ChemIDplus
Manual Xref Database
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Registry Numbers Types Sources
14609648 Reaxys Registry Number Reaxys
252916-29-3 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
24184958 PubMed citation Europe PMC
25472913 PubMed citation Europe PMC
25841919 PubMed citation Europe PMC
Last Modified
25 February 2016