CHEBI:90950 - Orkambi

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ChEBI Name Orkambi
Definition A two-drug mixture consisting of lumacaftor and ivacaftor, which is used for the treatment of cystic fibrosis.
Stars This entity has been manually annotated by the ChEBI Team.
Roles Classification
Biological Role(s): CFTR potentiator
A membrane transport modulator that restores the chloride ion transport ability of defective cystic fibrosis transmembrane conductance regulator (CFTR) genes.
Application(s): orphan drug
Any drug that has been developed specifically for treatment of a rare medical condition, the condition itself being known as an orphan disease.
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ChEBI Ontology
Outgoing Orkambi (CHEBI:90950) has part ivacaftor (CHEBI:66901)
Orkambi (CHEBI:90950) has part lumacaftor (CHEBI:90951)
Orkambi (CHEBI:90950) has role CFTR potentiator (CHEBI:66902)
Orkambi (CHEBI:90950) has role orphan drug (CHEBI:71031)
Orkambi (CHEBI:90950) is a mixture (CHEBI:60004)
Synonyms Sources
Ivacaftor - lumacaftor ChemIDplus
Ivacaftor / lumacaftor ChemIDplus
Ivacaftor and lumacaftor ChemIDplus
Ivacaftor mixture with lumacaftor ChemIDplus
Lumacaftor - ivacaftor mixt KEGG DRUG
Brand Name Source
Manual Xref Database
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Citations Waiting for Citations Types Sources
25981758 PubMed citation Europe PMC
26071414 PubMed citation Europe PMC
26416827 PubMed citation Europe PMC
26506855 PubMed citation Europe PMC
26510035 PubMed citation Europe PMC
26581802 PubMed citation Europe PMC
26718821 PubMed citation Europe PMC
Last Modified
14 January 2016
General Comment
2016-01-14 The mixture has a ChemIDplus registry number of S900006790 (for details see: