CHEBI:90948 - osimertinib mesylate

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ChEBI Name osimertinib mesylate
Definition A methanesulfonate (mesylate) salt prepared from equimolar amounts of osimertinib and methanesulfonic acid. It is used for treatment of EGFR T790M mutation positive non-small cell lung cancer.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C29H37N7O5S
Net Charge 0
Average Mass 595.715
Monoisotopic Mass 595.25769
InChI InChI=1S/C28H33N7O2.CH4O3S/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24;1-5(2,3)4/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32);1H3,(H,2,3,4)
Roles Classification
Biological Role(s): epidermal growth factor receptor antagonist
An antagonist at the epidermal growth factor receptor.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
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ChEBI Ontology
Outgoing osimertinib mesylate (CHEBI:90948) has part osimertinib(1+) (CHEBI:90949)
osimertinib mesylate (CHEBI:90948) has role antineoplastic agent (CHEBI:35610)
osimertinib mesylate (CHEBI:90948) has role epidermal growth factor receptor antagonist (CHEBI:74440)
osimertinib mesylate (CHEBI:90948) is a methanesulfonate salt (CHEBI:38037)
N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide methanesulfonate
Synonyms Sources
AZD9291 mesylate DrugCentral
osimertinib mesilate DrugCentral
osimertinib mesylate DrugCentral
osimertinib methanesulfonate ChEBI
osimertinib monomesylate ChEBI
Brand Name Source
Tagrisso DrugCentral
Manual Xref Database
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Registry Numbers Types Sources
1421373-66-1 CAS Registry Number ChemIDplus
23334374 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
26515464 PubMed citation Europe PMC
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Last Modified
09 February 2021