CHEBI:90933 - cariprazine

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ChEBI Name cariprazine
ChEBI ID CHEBI:90933
Definition An N-alkylpiperazine that is N,N-dimethyl-N'-{trans-4-[2-(piperazin-1-yl)ethyl]cyclohexyl}urea substituted at position 4 on the piperazine ring by a 2,3-dichlorophenyl group. Used (as the hydrochloride salt) for treatment of schizophrenia and bipolar disorder.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C21H32Cl2N4O
Net Charge 0
Average Mass 427.412
Monoisotopic Mass 426.19532
InChI InChI=1S/C21H32Cl2N4O/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23/h3-5,16-17H,6-15H2,1-2H3,(H,24,28)/t16-,17-
InChIKey KPWSJANDNDDRMB-QAQDUYKDSA-N
SMILES C1[C@H](CC[C@@H](C1)CCN2CCN(CC2)C=3C(=C(C=CC3)Cl)Cl)NC(N(C)C)=O
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): dopamine agonist
A drug that binds to and activates dopamine receptors.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
Application(s): dopamine agonist
A drug that binds to and activates dopamine receptors.
second generation antipsychotic
Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
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ChEBI Ontology
Outgoing cariprazine (CHEBI:90933) has role dopamine agonist (CHEBI:51065)
cariprazine (CHEBI:90933) has role second generation antipsychotic (CHEBI:65191)
cariprazine (CHEBI:90933) has role serotonergic antagonist (CHEBI:48279)
cariprazine (CHEBI:90933) is a N-alkylpiperazine (CHEBI:46845)
cariprazine (CHEBI:90933) is a N-arylpiperazine (CHEBI:46848)
cariprazine (CHEBI:90933) is a dichlorobenzene (CHEBI:23697)
cariprazine (CHEBI:90933) is a ureas (CHEBI:47857)
cariprazine (CHEBI:90933) is conjugate base of cariprazine(1+) (CHEBI:90934)
Incoming cariprazine(1+) (CHEBI:90934) is conjugate acid of cariprazine (CHEBI:90933)
IUPAC Name
N'-(trans-4-{2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl}cyclohexyl)-N,N-dimethylurea
INN Source
cariprazine KEGG DRUG
Synonyms Sources
RGH 188 ChemIDplus
RGH-188 ChemIDplus
Manual Xrefs Databases
5037 DrugCentral
Cariprazine Wikipedia
D09997 KEGG DRUG
DB06016 DrugBank
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Registry Numbers Types Sources
18784658 Reaxys Registry Number Reaxys
839712-12-8 CAS Registry Number KEGG DRUG
839712-12-8 CAS Registry Number ChemIDplus
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Last Modified
22 February 2017