CHEBI:90865 - flibanserin

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ChEBI Name flibanserin
ChEBI ID CHEBI:90865
Definition An N-alkylpiperazine that is 1-[2-(1,3-dihydro-2-oxobenzimidazol-1-yl)ethyl]piperazine in which the remaining amino proton is replaced by a 3-(trifluoromethyl)phenyl group. A multifunctional serotonin agonist and antagonist which is used for the treatment of pre-menopausal women with hypoactive sexual desire disorder.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C20H21F3N4O
Net Charge 0
Average Mass 390.403
Monoisotopic Mass 390.167
InChI InChI=1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12-26)10-13-27-18-7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28)
InChIKey PPRRDFIXUUSXRA-UHFFFAOYSA-N
SMILES C1=C(C=C(C=C1)C(F)(F)F)N2CCN(CC2)CCN3C4=C(NC3=O)C=CC=C4
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): serotonergic agonist
An agent that has an affinity for serotonin receptors and is able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. Serotonin agonists are used as antidepressants, anxiolytics, and in the treatment of migraine disorders.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
Application(s): serotonergic agonist
An agent that has an affinity for serotonin receptors and is able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. Serotonin agonists are used as antidepressants, anxiolytics, and in the treatment of migraine disorders.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
antidepressant
Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
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ChEBI Ontology
Outgoing flibanserin (CHEBI:90865) has role antidepressant (CHEBI:35469)
flibanserin (CHEBI:90865) has role serotonergic agonist (CHEBI:35941)
flibanserin (CHEBI:90865) has role serotonergic antagonist (CHEBI:48279)
flibanserin (CHEBI:90865) is a N-alkylpiperazine (CHEBI:46845)
flibanserin (CHEBI:90865) is a N-arylpiperazine (CHEBI:46848)
flibanserin (CHEBI:90865) is a benzimidazoles (CHEBI:22715)
flibanserin (CHEBI:90865) is a organofluorine compound (CHEBI:37143)
IUPAC Name
1-(2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethyl)-1,3-dihydro-2H-benzimidazol-2-one
INN Source
flibanserin KEGG DRUG
Synonyms Sources
1,3-Dihydro-1-(2-(4-(3-(trifluoromethyl)phenyl)-1-piperazinyl)ethyl)-2H-benzimidazol-2-one ChemIDplus
1-(2-(4-alpha,alpha,alpha-Trifluoro-m-tolyl)-1-(piperazinyl)ethyl)-2-benzimidazolinone ChemIDplus
Bimt 17 ChemIDplus
BIMT 17 BS ChemIDplus
Bimt-17 ChemIDplus
Female Viagra (Street Name) ChemIDplus
Brand Name Source
Addyi KEGG DRUG
Manual Xrefs Databases
5022 DrugCentral
D02577 KEGG DRUG
Flibanserin Wikipedia
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Registry Numbers Types Sources
167933-07-5 CAS Registry Number KEGG DRUG
167933-07-5 CAS Registry Number ChemIDplus
8942243 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
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Last Modified
22 February 2017