CHEBI:90705 - SB 203580

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ChEBI Name SB 203580
ChEBI ID CHEBI:90705
Definition A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C21H16FN3OS
Net Charge 0
Average Mass 377.437
Monoisotopic Mass 377.100
InChI InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)
InChIKey CDMGBJANTYXAIV-UHFFFAOYSA-N
SMILES S(C=1C=CC(C2=NC(C=3C=CN=CC3)=C(N2)C4=CC=C(C=C4)F)=CC1)(C)=O
Roles Classification
Biological Role(s): EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of mitogen-activated protein kinase (EC 2.7.11.24).
Hsp90 inhibitor
An EC 3.6.4.10 (non-chaperonin molecular chaperone ATPase) inhibitor that blocks the action of heat shock protein 90.
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine.
Application(s): neuroprotective agent
Any compound that can be used for the treatment of neurodegenerative disorders.
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ChEBI Ontology
Outgoing SB 203580 (CHEBI:90705) has role EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor (CHEBI:50925)
SB 203580 (CHEBI:90705) has role EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor (CHEBI:79091)
SB 203580 (CHEBI:90705) has role Hsp90 inhibitor (CHEBI:63962)
SB 203580 (CHEBI:90705) has role neuroprotective agent (CHEBI:63726)
SB 203580 (CHEBI:90705) is a imidazoles (CHEBI:24780)
SB 203580 (CHEBI:90705) is a monofluorobenzenes (CHEBI:83575)
SB 203580 (CHEBI:90705) is a pyridines (CHEBI:26421)
SB 203580 (CHEBI:90705) is a sulfoxide (CHEBI:22063)
IUPAC Name
4-{4-(4-fluorophenyl)-2-[4-(methanesulfinyl)phenyl]-1H-imidazol-5-yl}pyridine
Synonyms Sources
4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole ChemIDplus
SB-203580 ChemIDplus
SB203580 ChEBI
Manual Xref Database
LSM-1168 LINCS
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Registry Numbers Types Sources
152121-47-6 CAS Registry Number ChemIDplus
8078222 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
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Last Modified
08 July 2016