CHEBI:90682 - torin 2

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ChEBI Name torin 2
Definition A member of the class of pyridoquinolines that is benzo[h][1,6]naphthyridin-2-one carrying additional 3-(trifluoromethyl)phenyl and 6-aminopyridin-3-yl substituents at positions 1 and 9 respectively. It is a potent inhibitor of mTOR and exhibits anti-cancer properties.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Matthias Ziehm
Supplier Information
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Formula C24H15F3N4O
Net Charge 0
Average Mass 432.398
Monoisotopic Mass 432.120
InChI InChI=1S/C24H15F3N4O/c25-24(26,27)17-2-1-3-18(11-17)31-22(32)9-6-16-13-29-20-7-4-14(10-19(20)23(16)31)15-5-8-21(28)30-12-15/h1-13H,(H2,28,30)
SMILES C1=C(C2=CC=C3C(=C2)C4=C(C=CC(N4C5=CC(=CC=C5)C(F)(F)F)=O)C=N3)C=NC(=C1)N
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): mTOR inhibitor
A protein kinase inhibitor of the mammalian target of rapamycin (mTOR), a protein that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis and transcription. mTOR inhibitors are used to prevent transplant rejection and in treatment of cancer.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing torin 2 (CHEBI:90682) has role antineoplastic agent (CHEBI:35610)
torin 2 (CHEBI:90682) has role mTOR inhibitor (CHEBI:68481)
torin 2 (CHEBI:90682) is a aminopyridine (CHEBI:38207)
torin 2 (CHEBI:90682) is a organofluorine compound (CHEBI:37143)
torin 2 (CHEBI:90682) is a primary amino compound (CHEBI:50994)
torin 2 (CHEBI:90682) is a pyridoquinoline (CHEBI:38921)
Synonym Source
torin2 ChEBI
Manual Xrefs Databases
17G PDBeChem
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Registry Number Type Source
20268159 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
23436801 PubMed citation Europe PMC
23636326 PubMed citation Europe PMC
24459013 PubMed citation Europe PMC
24583924 PubMed citation Europe PMC
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24801387 PubMed citation Europe PMC
25296981 PubMed citation Europe PMC
25945839 PubMed citation Europe PMC
26023849 PubMed citation Europe PMC
26239364 PubMed citation Europe PMC
26722032 PubMed citation Europe PMC
Last Modified
08 July 2016