CHEBI:90626 - AMG-208

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ChEBI Name AMG-208
ChEBI ID CHEBI:90626
Definition A member of the class of quinolines that is 7-methoxyquinoline substituted at position 4 by a (6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy group. AMG exhibits antitumour activity, particularly in prostate cancer.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Matthias Ziehm
Supplier Information
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Formula C22H17N5O2
Net Charge 0
Average Mass 383.404
Monoisotopic Mass 383.138
InChI InChI=1S/C22H17N5O2/c1-28-16-7-8-17-19(13-16)23-12-11-20(17)29-14-22-25-24-21-10-9-18(26-27(21)22)15-5-3-2-4-6-15/h2-13H,14H2,1H3
InChIKey HEAIZQNMNCHNFD-UHFFFAOYSA-N
SMILES N1=C(C2=CC=CC=C2)C=CC3=NN=C(COC4=C5C(C=C(C=C5)OC)=NC=C4)N13
Roles Classification
Biological Role(s): c-Met tyrosine kinase inhibitor
An EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor that interferes with the action of c-Met tyrosine kinase.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing AMG-208 (CHEBI:90626) has role antineoplastic agent (CHEBI:35610)
AMG-208 (CHEBI:90626) has role c-Met tyrosine kinase inhibitor (CHEBI:90199)
AMG-208 (CHEBI:90626) is a aromatic ether (CHEBI:35618)
AMG-208 (CHEBI:90626) is a quinolines (CHEBI:26513)
AMG-208 (CHEBI:90626) is a triazolopyridazine (CHEBI:48384)
IUPAC Name
7-methoxy-4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline
Synonyms Sources
AMG 208 ChEBI
AMG208 ChEBI
Manual Xrefs Databases
DB08079 DrugBank
L5G PDBeChem
View more database links
Registry Number Type Source
1002304-34-8 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
18426196 PubMed citation Europe PMC
26155941 PubMed citation Europe PMC
Last Modified
11 July 2018