CHEBI:90624 - SGX-523

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ChEBI Name SGX-523
ChEBI ID CHEBI:90624
Definition A member of the class of triazolopyridazines that is 6-(1-methylpyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazine-3-thiol in which the thiol hydrogen is replaced by a quinolin-6-yl group.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Matthias Ziehm
Supplier Information
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Formula C18H13N7S
Net Charge 0
Average Mass 359.409
Monoisotopic Mass 359.095
InChI InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3
InChIKey BCZUAADEACICHN-UHFFFAOYSA-N
SMILES C=1C=2N(N=C(C1)C=3C=NN(C)C3)C(SC4=CC=C5C(=C4)C=CC=N5)=NN2
Roles Classification
Biological Role(s): c-Met tyrosine kinase inhibitor
An EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor that interferes with the action of c-Met tyrosine kinase.
nephrotoxic agent
A role played by a chemical compound exihibiting itself through the ability to induce damage to the kidney in animals.
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ChEBI Ontology
Outgoing SGX-523 (CHEBI:90624) has role c-Met tyrosine kinase inhibitor (CHEBI:90199)
SGX-523 (CHEBI:90624) has role nephrotoxic agent (CHEBI:50909)
SGX-523 (CHEBI:90624) is a aryl sulfide (CHEBI:35683)
SGX-523 (CHEBI:90624) is a biaryl (CHEBI:64459)
SGX-523 (CHEBI:90624) is a pyrazoles (CHEBI:26410)
SGX-523 (CHEBI:90624) is a quinolines (CHEBI:26513)
SGX-523 (CHEBI:90624) is a triazolopyridazine (CHEBI:48384)
IUPAC Name
6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline
Synonyms Sources
SGX-523 ChemIDplus
SGX523 ChemIDplus
Manual Xrefs Databases
DB08584 DrugBank
LSM-1123 LINCS
SX8 PDBeChem
View more database links
Registry Numbers Types Sources
1022150-57-7 CAS Registry Number ChemIDplus
18321133 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
19934279 PubMed citation Europe PMC
22547164 PubMed citation Europe PMC
Last Modified
24 February 2016