CHEBI:90524 - PI-103

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ChEBI Name PI-103
ChEBI ID CHEBI:90524
Definition An organic heterotricyclic compound that is pyrido[3',2':4,5]furo[3,2-d]pyrimidine substituted at positions 2 and 4 by 3-hydroxyphenyl and morpholin-4-yl groups respectively. A dual-kinase inhibitor with anti-cancer properties.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Matthias Ziehm
Supplier Information
Download Molfile XML SDF
Formula C19H16N4O3
Net Charge 0
Average Mass 348.356
Monoisotopic Mass 348.122
InChI InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2
InChIKey TUVCWJQQGGETHL-UHFFFAOYSA-N
SMILES N=1C=CC=C2C1OC=3C2=NC(=NC3N4CCOCC4)C=5C=CC=C(O)C5
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
An inhibitor of phosphatidylinositol 3-kinase, EC 2.7.1.137, a family of related enzymes capable of phosphorylating the 3 position hydroxy group of the inositol ring of a phosphatidylinositol.
mTOR inhibitor
A protein kinase inhibitor of the mammalian target of rapamycin (mTOR), a protein that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis and transcription. mTOR inhibitors are used to prevent transplant rejection and in treatment of cancer.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing PI-103 (CHEBI:90524) has role antineoplastic agent (CHEBI:35610)
PI-103 (CHEBI:90524) has role EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor (CHEBI:50914)
PI-103 (CHEBI:90524) has role mTOR inhibitor (CHEBI:68481)
PI-103 (CHEBI:90524) is a aromatic amine (CHEBI:33860)
PI-103 (CHEBI:90524) is a morpholines (CHEBI:38785)
PI-103 (CHEBI:90524) is a organic heterotricyclic compound (CHEBI:26979)
PI-103 (CHEBI:90524) is a phenols (CHEBI:33853)
PI-103 (CHEBI:90524) is a tertiary amino compound (CHEBI:50996)
IUPAC Name
3-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol
Synonyms Sources
pi-103 ChemIDplus
PIK-103 ChemIDplus
Manual Xrefs Databases
LSM-1126 LINCS
X6K PDBeChem
View more database links
Registry Numbers Types Sources
11065715 Reaxys Registry Number Reaxys
371935-74-9 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
20339072 PubMed citation Europe PMC
23636326 PubMed citation Europe PMC
24900786 PubMed citation Europe PMC
25575882 PubMed citation Europe PMC
25721419 PubMed citation Europe PMC
25884663 PubMed citation Europe PMC
26121251 PubMed citation Europe PMC
Last Modified
08 July 2016