CHEBI:88339 - BMS-754807

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ChEBI Name BMS-754807
ChEBI ID CHEBI:88339
Definition A pyrrolotriazine that is pyrrolo[2,1-f][1,2,4]triazine which is substituted at position 2 by the pyrrolidine nitrogen of (2S)-N-(6-fluoropyridin-3-yl)-2-methylprolinamide, and at position 4 by a (5-cyclopropyl-1H-pyrazol-3-yl)amino group. It is a potent, reversible inhibitor of the insulin-like growth factor 1 receptor/insulin receptor family kinases.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C23H24FN9O
Net Charge 0
Average Mass 461.496
Monoisotopic Mass 461.209
InChI InChI=1S/C23H24FN9O/c1-23(21(34)26-15-7-8-18(24)25-13-15)9-3-10-32(23)22-28-20(17-4-2-11-33(17)31-22)27-19-12-16(29-30-19)14-5-6-14/h2,4,7-8,11-14H,3,5-6,9-10H2,1H3,(H,26,34)(H2,27,28,29,30,31)/t23-/m0/s1
InChIKey LQVXSNNAFNGRAH-QHCPKHFHSA-N
SMILES N1([C@@](CCC1)(C(=O)NC2=CN=C(C=C2)F)C)C3=NN4C(C(=N3)NC5=NNC(=C5)C6CC6)=CC=C4
Roles Classification
Biological Role(s): EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
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ChEBI Ontology
Outgoing BMS-754807 (CHEBI:88339) has role antineoplastic agent (CHEBI:35610)
BMS-754807 (CHEBI:88339) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
BMS-754807 (CHEBI:88339) is a pyrazoles (CHEBI:26410)
BMS-754807 (CHEBI:88339) is a pyridines (CHEBI:26421)
BMS-754807 (CHEBI:88339) is a pyrrolidines (CHEBI:38260)
BMS-754807 (CHEBI:88339) is a pyrrolotriazine (CHEBI:88341)
IUPAC Name
1-{4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}-N-(6-fluoropyridin-3-yl)-2-methyl-L-prolinamide
Synonym Source
BMS 754807 ChemIDplus
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EBI PDBeChem
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Citations Waiting for Citations Types Sources
19996272 PubMed citation Europe PMC
20807811 PubMed citation Europe PMC
23047891 PubMed citation Europe PMC
25527633 PubMed citation Europe PMC
25748921 PubMed citation Europe PMC
Last Modified
25 February 2016