CHEBI:88316 - nefopam

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name nefopam
ChEBI ID CHEBI:88316
Definition A racemate comprising equal amounts of (R)- and (S)-nefopam. The hydrochloride is a centrally acting non-opiate analgesic commonly used for the treatment of moderate to severe pain.
Stars This entity has been manually annotated by the ChEBI Team.
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Roles Classification
Biological Role(s): adrenergic uptake inhibitor
Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
dopamine uptake inhibitor
A dopaminergic agent that blocks the transport of dopamine into axon terminals or into storage vesicles within terminals. Most of the adrenergic uptake inhibitors also inhibit dopamine uptake.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
serotonin uptake inhibitor
A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent.
Application(s): adrenergic uptake inhibitor
Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
dopamine uptake inhibitor
A dopaminergic agent that blocks the transport of dopamine into axon terminals or into storage vesicles within terminals. Most of the adrenergic uptake inhibitors also inhibit dopamine uptake.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
serotonin uptake inhibitor
A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing nefopam (CHEBI:88316) has part (R)-nefopam (CHEBI:88323)
nefopam (CHEBI:88316) has part (S)-nefopam (CHEBI:88320)
nefopam (CHEBI:88316) has role adrenergic uptake inhibitor (CHEBI:35640)
nefopam (CHEBI:88316) has role dopamine uptake inhibitor (CHEBI:51039)
nefopam (CHEBI:88316) has role non-narcotic analgesic (CHEBI:35481)
nefopam (CHEBI:88316) has role serotonin uptake inhibitor (CHEBI:50949)
nefopam (CHEBI:88316) is a racemate (CHEBI:60911)
IUPAC Name
rac-5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine
INNs Sources
nefopam KEGG DRUG
nefopamum ChemIDplus
Synonym Source
3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocin ChemIDplus
Manual Xrefs Databases
D08258 KEGG DRUG
Nefopam Wikipedia
View more database links
Registry Numbers Types Sources
1217383 Reaxys Registry Number Reaxys
13669-70-0 CAS Registry Number ChemIDplus
13669-70-0 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
23140663 PubMed citation Europe PMC
25534502 PubMed citation Europe PMC
25664155 PubMed citation Europe PMC
25855761 PubMed citation Europe PMC
25903742 PubMed citation Europe PMC
26047392 PubMed citation Europe PMC
26055978 PubMed citation Europe PMC
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26475417 PubMed citation Europe PMC
Last Modified
22 February 2017