CHEBI:88249 - PD 0325901

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ChEBI Name PD 0325901
Definition A hydroxamic acid ester that is benzhydroxamic acid (N-hydroxybenzamide) in which the hydroxamic acid group has been converted to the corresponding 2,3-dihydroxypropyl ester and in which the benzene ring has been substituted at position 2 by a (2-fluoro-4-iodophenyl)amino group and at positions 3 and 4 by fluorines (the R enantiomer).
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C16H14F3IN2O4
Net Charge 0
Average Mass 482.194
Monoisotopic Mass 481.99504
InChI InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC (mitogen-activated protein kinase kinase) inhibitor
An EC 2.7.12.* [dual-specificity kinases (those acting on Ser/Thr and Tyr residues)] inhibitor that inhibits the action of mitogen-activated protein kinase kinase (EC
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
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ChEBI Ontology
Outgoing PD 0325901 (CHEBI:88249) has role antineoplastic agent (CHEBI:35610)
PD 0325901 (CHEBI:88249) has role EC (mitogen-activated protein kinase kinase) inhibitor (CHEBI:88286)
PD 0325901 (CHEBI:88249) is a difluorobenzene (CHEBI:38582)
PD 0325901 (CHEBI:88249) is a hydroxamic acid ester (CHEBI:75606)
PD 0325901 (CHEBI:88249) is a monofluorobenzenes (CHEBI:83575)
PD 0325901 (CHEBI:88249) is a organoiodine compound (CHEBI:37142)
PD 0325901 (CHEBI:88249) is a propane-1,2-diols (CHEBI:26284)
PD 0325901 (CHEBI:88249) is a secondary amino compound (CHEBI:50995)
Synonyms Sources
PD 325901 ChemIDplus
PD-0325901 ChEBI
PD-325901 ChemIDplus
PD0325901 ChemIDplus
Manual Xref Database
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Registry Numbers Types Sources
11343179 Reaxys Registry Number Reaxys
391210-10-9 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
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Last Modified
24 February 2016