CHEBI:87681 - ranolazine

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name ranolazine
ChEBI ID CHEBI:87681
Definition A racemate comprising equal amounts of (R)- and (S)-ranolazine. Used for treatment of chronic angina.
Stars This entity has been manually annotated by the ChEBI Team.
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C24H33N3O4
Net Charge 0
Average Mass 427.537
Roles Classification
Biological Role(s): sodium channel blocker
An agent that inhibits sodium influx through cell membranes.
Application(s): anti-arrhythmia drug
A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing ranolazine (CHEBI:87681) has part (R)-ranolazine (CHEBI:87696)
ranolazine (CHEBI:87681) has part (S)-ranolazine (CHEBI:87693)
ranolazine (CHEBI:87681) has role anti-arrhythmia drug (CHEBI:38070)
ranolazine (CHEBI:87681) has role sodium channel blocker (CHEBI:38633)
ranolazine (CHEBI:87681) is a racemate (CHEBI:60911)
IUPAC Name
rac-N-(2,6-dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamide
INN Source
ranolazine KEGG DRUG
Synonyms Sources
(+-)-N-(2,6-Dimethylphenyl)-4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)-1-piperazineacetamide ChemIDplus
(+-)-Ranolazine ChemIDplus
(RS)-ranolazine ChEBI
rac-ranolazine ChEBI
racemic ranolazine ChEBI
Brand Name Source
Ranexa ChemIDplus
Manual Xrefs Databases
D05700 KEGG DRUG
DB00243 DrugBank
EP126449 Patent
Ranolazine Wikipedia
US4567264 Patent
View more database links
Registry Numbers Types Sources
8234797 Reaxys Registry Number Reaxys
95635-55-5 CAS Registry Number ChemIDplus
95635-55-5 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
25041234 PubMed citation Europe PMC
25188881 PubMed citation Europe PMC
25210025 PubMed citation Europe PMC
25346368 PubMed citation Europe PMC
25346483 PubMed citation Europe PMC
25416563 PubMed citation Europe PMC
25496982 PubMed citation Europe PMC
25515836 PubMed citation Europe PMC
25544118 PubMed citation Europe PMC
25555283 PubMed citation Europe PMC
25602175 PubMed citation Europe PMC
25738014 PubMed citation Europe PMC
25761430 PubMed citation Europe PMC
25828315 PubMed citation Europe PMC
25848292 PubMed citation Europe PMC
25872749 PubMed citation Europe PMC
26021246 PubMed citation Europe PMC
26049552 PubMed citation Europe PMC
26049922 PubMed citation Europe PMC
26059896 PubMed citation Europe PMC
26138210 PubMed citation Europe PMC
26183665 PubMed citation Europe PMC
26185330 PubMed citation Europe PMC
26226999 PubMed citation Europe PMC
26245658 PubMed citation Europe PMC
Last Modified
22 February 2017