CHEBI:87631 - statin

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ChEBI Name statin
Definition Any organooxygen compound whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC (hydroxymethylglutaryl-CoA reductase) inhibitory properties.
Stars This entity has been manually annotated by the ChEBI Team.
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Roles Classification
Biological Role(s): EC (hydroxymethylglutaryl-CoA reductase) inhibitor
Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC for the NADPH-dependent enzyme and EC for an NADH-dependent enzyme.
Application(s): anticholesteremic drug
A substance used to lower plasma cholesterol levels.
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ChEBI Ontology
Outgoing statin (CHEBI:87631) has role anticholesteremic drug (CHEBI:35821)
statin (CHEBI:87631) has role EC (hydroxymethylglutaryl-CoA reductase) inhibitor (CHEBI:35664)
statin (CHEBI:87631) is a organooxygen compound (CHEBI:36963)
Incoming statin (naturally occurring) (CHEBI:87632) is a statin (CHEBI:87631)
statin (semi-synthetic) (CHEBI:87633) is a statin (CHEBI:87631)
statin (synthetic) (CHEBI:87635) is a statin (CHEBI:87631)
Synonym Source
statins ChEBI
Manual Xref Database
Statin Wikipedia
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Last Modified
28 January 2016