CHEBI:85010 - eltrombopag

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name eltrombopag
ChEBI ID CHEBI:85010
Definition A hydrazine in which each nitrogen atom is substituted, one by a 3'-carboxy-2-hydroxy[1,1'-biphenyl]-3-yl group and the other by a 1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene group. A small molecule agonist of the c-mpl (TpoR) receptor (the physiological target of the hormone thrombopoietin), it has been developed as a medication for conditions that lead to thrombocytopenia (abnormally low platelet counts).
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C25H22N4O4
Net Charge 0
Average Mass 442.46660
Monoisotopic Mass 442.164
InChI InChI=1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,26,30H,1-3H3,(H,32,33)/b27-22-
InChIKey XDXWLKQMMKQXPV-QYQHSDTDSA-N
SMILES CC1=NN(C(=O)\C1=N/Nc1cccc(-c2cccc(c2)C(O)=O)c1O)c1ccc(C)c(C)c1
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): thrombopoietin receptor agonist
An agonist that selectively binds to and activates the thrombopoietin receptor [myeloproliferative leukemia protein or CD110 (Cluster of Differentiation 110)].
xenobiotic
A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing eltrombopag (CHEBI:85010) has role thrombopoietin receptor agonist (CHEBI:85012)
eltrombopag (CHEBI:85010) has role xenobiotic (CHEBI:35703)
eltrombopag (CHEBI:85010) is a benzoic acids (CHEBI:22723)
eltrombopag (CHEBI:85010) is a hydrazines (CHEBI:24631)
eltrombopag (CHEBI:85010) is a pyrazoles (CHEBI:26410)
IUPAC Name
3'-{(2Z)-2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazinyl}-2'-hydroxy[1,1'-biphenyl]-3-carboxylic acid
Synonym Source
3'-{(2Z)-2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazino}-2'-hydroxybiphenyl-3-carboxylic acid IUPAC
Manual Xrefs Databases
4399 DrugCentral
Eltrombopag Wikipedia
View more database links
Registry Number Type Source
496775-61-2 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
24433306 PubMed citation Europe PMC
25063763 PubMed citation Europe PMC
25170628 PubMed citation Europe PMC
25400215 PubMed citation Europe PMC
25578417 PubMed citation Europe PMC
25700916 PubMed citation Europe PMC
Last Modified
22 February 2017