CHEBI:8427 - probucol

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ChEBI Name probucol
ChEBI ID CHEBI:8427
Definition A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C31H48O2S2
Net Charge 0
Average Mass 516.84200
Monoisotopic Mass 516.310
InChI InChI=1S/C31H48O2S2/c1-27(2,3)21-15-19(16-22(25(21)32)28(4,5)6)34-31(13,14)35-20-17-23(29(7,8)9)26(33)24(18-20)30(10,11)12/h15-18,32-33H,1-14H3
InChIKey FYPMFJGVHOHGLL-UHFFFAOYSA-N
SMILES CC(C)(Sc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C)Sc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
Roles Classification
Chemical Role(s): antioxidant
A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
Application(s): anti-inflammatory drug
A substance that reduces or suppresses inflammation.
cardiovascular drug
A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
antilipemic drug
A substance used to treat hyperlipidemia (an excess of lipids in the blood).
anticholesteremic drug
A substance used to lower plasma cholesterol levels.
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ChEBI Ontology
Outgoing probucol (CHEBI:8427) has role anti-inflammatory drug (CHEBI:35472)
probucol (CHEBI:8427) has role anticholesteremic drug (CHEBI:35821)
probucol (CHEBI:8427) has role antilipemic drug (CHEBI:35679)
probucol (CHEBI:8427) has role antioxidant (CHEBI:22586)
probucol (CHEBI:8427) has role cardiovascular drug (CHEBI:35554)
probucol (CHEBI:8427) is a dithioketal (CHEBI:59800)
probucol (CHEBI:8427) is a polyphenol (CHEBI:26195)
IUPAC Name
4,4'-(propane-2,2-diyldisulfanediyl)bis(2,6-di-tert-butylphenol)
INNs Sources
probucol WHO MedNet
probucol WHO MedNet
probucol WHO MedNet
probucolum ChemIDplus
Synonyms Sources
4,4'- (Isopropylidenedithio)bis(2,6-di-tert-butylphenol) HMDB
Acetone bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole HMDB
Biphenabid ChemIDplus
Bisbid ChemIDplus
Bisphenabid ChemIDplus
DH-581 ChEBI
Brand Names Sources
Lesterol ChemIDplus
Lorelco KEGG DRUG
Lurselle ChEBI
Serterol ChEBI
Superlipid ChEBI
Manual Xrefs Databases
2269 DrugCentral
C07373 KEGG COMPOUND
CN101423484 Patent
CN101455842 Patent
CN102973535 Patent
D00476 KEGG DRUG
DB01599 DrugBank
FR1561853 Patent
HMDB0015537 HMDB
LSM-3617 LINCS
Probucol Wikipedia
US3576883 Patent
US3862332 Patent
View more database links
Registry Numbers Types Sources
2026253 Reaxys Registry Number Reaxys
23288-49-5 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
22305809 PubMed citation Europe PMC
23107872 PubMed citation Europe PMC
23167559 PubMed citation Europe PMC
23334712 PubMed citation Europe PMC
23363981 PubMed citation Europe PMC
23378294 PubMed citation Europe PMC
23443157 PubMed citation Europe PMC
23741215 PubMed citation Europe PMC
Last Modified
22 February 2017