CHEBI:84115 - antazoline

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ChEBI Name antazoline
ChEBI ID CHEBI:84115
Definition A member of the class of imidazolines that is 2-aminomethyl-2-imidazoline in which the exocyclic amino hydrogens are replaced by benzyl and phenyl groups. Antazoline is only found in individuals that have taken the drug.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Toni Morrison
Supplier Information
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Formula C17H19N3
Net Charge 0
Average Mass 265.35290
Monoisotopic Mass 265.158
InChI InChI=1S/C17H19N3/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16/h1-10H,11-14H2,(H,18,19)
InChIKey REYFJDPCWQRWAA-UHFFFAOYSA-N
SMILES C(N(Cc1ccccc1)c1ccccc1)C1=NCCN1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
cholinergic antagonist
Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.
xenobiotic
A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
Application(s): H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
cholinergic antagonist
Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.
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ChEBI Ontology
Outgoing antazoline (CHEBI:84115) has role cholinergic antagonist (CHEBI:48873)
antazoline (CHEBI:84115) has role H1-receptor antagonist (CHEBI:37955)
antazoline (CHEBI:84115) has role xenobiotic (CHEBI:35703)
antazoline (CHEBI:84115) is a aromatic amine (CHEBI:33860)
antazoline (CHEBI:84115) is a imidazolines (CHEBI:53095)
antazoline (CHEBI:84115) is a tertiary amino compound (CHEBI:50996)
IUPAC Name
N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline
INNs Sources
antazolina ChemIDplus
antazoline ChemIDplus
antazoline KEGG DRUG
antazolinum ChemIDplus
Synonyms Sources
2-(N-Benzylanilinomethyl)-2-imidazoline ChemIDplus
2-(N-Phenyl-N-benzylaminomethyl)imidazoline ChemIDplus
4,5-Dihydro-N-phenyl-N-phenylmethyl-1H-imidazole-2-methanamine ChemIDplus
Manual Xrefs Databases
224 DrugCentral
Antazoline Wikipedia
D07458 KEGG DRUG
DB08799 DrugBank
HMDB0015689 HMDB
LSM-6023 LINCS
View more database links
Registry Numbers Types Sources
233924 Reaxys Registry Number Reaxys
91-75-8 CAS Registry Number ChemIDplus
91-75-8 CAS Registry Number KEGG DRUG
91-75-8 CAS Registry Number NIST Chemistry WebBook
Citations Waiting for Citations Types Sources
1180129 PubMed citation Europe PMC
16394564 PubMed citation Europe PMC
22967497 PubMed citation Europe PMC
23669609 PubMed citation Europe PMC
23847054 PubMed citation Europe PMC
23990192 PubMed citation Europe PMC
3793827 PubMed citation Europe PMC
5792228 PubMed citation Europe PMC
712601 PubMed citation Europe PMC
7199833 PubMed citation Europe PMC
9145778 PubMed citation Europe PMC
Last Modified
22 February 2017