CHEBI:83656 - luminespib

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ChEBI Name luminespib
ChEBI ID CHEBI:83656
Definition A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-(2,4-dihydroxy-5-isopropylphenyl)-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxylic acid with the amino group of ethylamine.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C26H31N3O5
Net Charge 0
Average Mass 465.54140
Monoisotopic Mass 465.226
InChI InChI=1S/C26H31N3O5/c1-4-27-26(32)24-23(18-7-5-17(6-8-18)15-29-9-11-33-12-10-29)25(34-28-24)20-13-19(16(2)3)21(30)14-22(20)31/h5-8,13-14,16,30-31H,4,9-12,15H2,1-3H3,(H,27,32)
InChIKey NDAZATDQFDPQBD-UHFFFAOYSA-N
SMILES CCNC(=O)c1noc(c1-c1ccc(CN2CCOCC2)cc1)-c1cc(C(C)C)c(O)cc1O
Roles Classification
Biological Role(s): Hsp90 inhibitor
An EC 3.6.4.10 (non-chaperonin molecular chaperone ATPase) inhibitor that blocks the action of heat shock protein 90.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
angiogenesis inhibitor
An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing luminespib (CHEBI:83656) has role angiogenesis inhibitor (CHEBI:48422)
luminespib (CHEBI:83656) has role antineoplastic agent (CHEBI:35610)
luminespib (CHEBI:83656) has role Hsp90 inhibitor (CHEBI:63962)
luminespib (CHEBI:83656) is a aromatic amide (CHEBI:62733)
luminespib (CHEBI:83656) is a isoxazoles (CHEBI:55373)
luminespib (CHEBI:83656) is a monocarboxylic acid amide (CHEBI:29347)
luminespib (CHEBI:83656) is a morpholines (CHEBI:38785)
luminespib (CHEBI:83656) is a resorcinols (CHEBI:33572)
IUPAC Name
5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide
Synonym Source
NVP-AUY922 ChEBI
Manual Xref Database
NVP-AUY922 Wikipedia
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Registry Numbers Types Sources
12046798 Reaxys Registry Number Reaxys
747412-49-3 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
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Last Modified
07 November 2014