CHEBI:83168 - acrivastine

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ChEBI Name acrivastine
ChEBI ID CHEBI:83168
Definition A member of the class of pyridines that is (pyridin-2-yl)acrylic acid substituted at position 6 by a [(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl group. It is a non-sedating antihistamine used for treatment of hayfever, urticaria, and rhinitis.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Toni Morrison
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Formula C22H24N2O2
Net Charge 0
Average Mass 348.43820
Monoisotopic Mass 348.184
InChI InChI=1S/C22H24N2O2/c1-17-7-9-18(10-8-17)20(13-16-24-14-2-3-15-24)21-6-4-5-19(23-21)11-12-22(25)26/h4-13H,2-3,14-16H2,1H3,(H,25,26)/b12-11+,20-13+
InChIKey PWACSDKDOHSSQD-IUTFFREVSA-N
SMILES Cc1ccc(cc1)C(=C/CN1CCCC1)\c1cccc(\C=C\C(O)=O)n1
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
Application(s): H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
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ChEBI Ontology
Outgoing acrivastine (CHEBI:83168) has role H1-receptor antagonist (CHEBI:37955)
acrivastine (CHEBI:83168) is a α,β-unsaturated monocarboxylic acid (CHEBI:79020)
acrivastine (CHEBI:83168) is a N-alkylpyrrolidine (CHEBI:46775)
acrivastine (CHEBI:83168) is a olefinic compound (CHEBI:78840)
acrivastine (CHEBI:83168) is a pyridines (CHEBI:26421)
IUPAC Name
(2E)-3-{6-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridin-2-yl}acrylic acid
INNs Sources
acrivastina ChemIDplus
acrivastine ChemIDplus
acrivastine KEGG DRUG
acrivastinum ChemIDplus
Synonyms Sources
(E)-6-((E)-3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)-2-pyridineacrylic acid ChemIDplus
BW 825C ChemIDplus
BW A825C ChemIDplus
Manual Xrefs Databases
82 DrugCentral
Acrivastine Wikipedia
D02760 KEGG DRUG
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Registry Numbers Types Sources
6739893 Reaxys Registry Number Reaxys
87848-99-5 CAS Registry Number KEGG DRUG
87848-99-5 CAS Registry Number ChemIDplus
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Last Modified
22 February 2017