CHEBI:82978 - paliperidone

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ChEBI Name paliperidone
ChEBI ID CHEBI:82978
Definition A racemate comprising equimolar amounts of (R)- and (S)-paliperidone. Paliperidone is the primary active metabolite of the older antipsychotic risperidone and is used for treatment of schizophrenia.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Toni Morrison
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Formula C23H27FN4O3
Net Charge 0
Average Mass 426.48390
Roles Classification
Biological Role(s): dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
drug metabolite

alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
Application(s): dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
psychotropic drug
A loosely defined grouping of drugs that have effects on psychological function.
second generation antipsychotic
Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements.
neuroprotective agent
Any compound that can be used for the treatment of neurodegenerative disorders.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing paliperidone (CHEBI:82978) has part (R)-paliperidone (CHEBI:83806)
paliperidone (CHEBI:82978) has part (S)-paliperidone (CHEBI:83805)
paliperidone (CHEBI:82978) has role α-adrenergic antagonist (CHEBI:37890)
paliperidone (CHEBI:82978) has role dopaminergic antagonist (CHEBI:48561)
paliperidone (CHEBI:82978) has role drug metabolite (CHEBI:49103)
paliperidone (CHEBI:82978) has role H1-receptor antagonist (CHEBI:37955)
paliperidone (CHEBI:82978) has role neuroprotective agent (CHEBI:63726)
paliperidone (CHEBI:82978) has role psychotropic drug (CHEBI:35471)
paliperidone (CHEBI:82978) has role second generation antipsychotic (CHEBI:65191)
paliperidone (CHEBI:82978) has role serotonergic antagonist (CHEBI:48279)
paliperidone (CHEBI:82978) is a racemate (CHEBI:60911)
IUPAC Name
rac-3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
INN Source
paliperidone KEGG DRUG
Synonyms Sources
(±)-paliperidone ChemIDplus
(RS)-paliperidone ChemIDplus
9-hydroxy-risperidone ChemIDplus
9-Hydroxyrisperidone DrugBank
9-OH-risperidone ChemIDplus
R 76477 ChemIDplus
R-76477 ChemIDplus
rac-paliperidone ChemIDplus
racemic paliperidone ChemIDplus
Ro-76477 DrugBank
RO76477 ChemIDplus
Brand Name Source
Invega KEGG DRUG
Manual Xrefs Databases
D05339 KEGG DRUG
DB01267 DrugBank
HMDB0015396 HMDB
Paliperidone Wikipedia
View more database links
Registry Numbers Types Sources
144598-75-4 CAS Registry Number KEGG DRUG
144598-75-4 CAS Registry Number ChemIDplus
8808385 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
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Last Modified
22 February 2017