CHEBI:8024 - perindopril

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ChEBI Name perindopril
Definition An α-amino acid ester that is the ethyl ester of N-{(2S)-1-[(2S,3aS,7aS)-2-carboxyoctahydro-1H-indol-1-yl]-1-oxopropan-2-yl}-L-norvaline
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C19H32N2O5
Net Charge 0
Average Mass 368.46786
Monoisotopic Mass 368.23112
InChI InChI=1S/C19H32N2O5/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24/h12-16,20H,4-11H2,1-3H3,(H,23,24)/t12-,13-,14-,15-,16-/m0/s1
SMILES [H][C@@]12CCCC[C@]1([H])N([C@@H](C2)C(O)=O)C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): EC (peptidyl-dipeptidase A) inhibitor
An EC 3.4.15.* (peptidyl-dipeptidase) inhibitor that interferes with the action of peptidyl-dipeptidase A (EC
Application(s): EC (peptidyl-dipeptidase A) inhibitor
An EC 3.4.15.* (peptidyl-dipeptidase) inhibitor that interferes with the action of peptidyl-dipeptidase A (EC
antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
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ChEBI Ontology
Outgoing perindopril (CHEBI:8024) has role antihypertensive agent (CHEBI:35674)
perindopril (CHEBI:8024) has role EC (peptidyl-dipeptidase A) inhibitor (CHEBI:35457)
perindopril (CHEBI:8024) is a α-amino acid ester (CHEBI:46874)
perindopril (CHEBI:8024) is a dicarboxylic acid monoester (CHEBI:36244)
perindopril (CHEBI:8024) is a ethyl ester (CHEBI:23990)
perindopril (CHEBI:8024) is a organic heterobicyclic compound (CHEBI:27171)
perindopril (CHEBI:8024) is conjugate acid of perindopril(1−) (CHEBI:78000)
Incoming perindopril(1−) (CHEBI:78000) is conjugate base of perindopril (CHEBI:8024)
ethyl N-{(2S)-1-[(2S,3aS,7aS)-2-carboxyoctahydro-1H-indol-1-yl]-1-oxopropan-2-yl}-L-norvalinate
INNs Sources
perindopril ChemIDplus
perindoprilum ChemIDplus
Synonym Source
(2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxopentan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid IUPAC
Manual Xrefs Databases
2108 DrugCentral
DB00790 DrugBank
HMDB0014928 HMDB
Perindopril Wikipedia
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Registry Numbers Types Sources
4300272 Reaxys Registry Number Reaxys
82834-16-0 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
24291100 PubMed citation Europe PMC
24324048 PubMed citation Europe PMC
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24511479 PubMed citation Europe PMC
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24590580 PubMed citation Europe PMC
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24664905 PubMed citation Europe PMC
Last Modified
22 February 2017