CHEBI:78538 - tafamidis

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ChEBI Name tafamidis
Definition A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazole-6-carboxylic acid in which the hydrogen at position 2 is replaced by a 3,5-dichlorophenyl group. Used (as its meglumine salt) for the amelioration of transthyretin-related hereditary amyloidosis.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Toni Morrison
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Formula C14H7Cl2NO3
Net Charge 0
Average Mass 308.11600
Monoisotopic Mass 306.98030
InChI InChI=1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6H,(H,18,19)
SMILES OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Application(s): central nervous system drug
A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system.
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ChEBI Ontology
Outgoing tafamidis (CHEBI:78538) has role central nervous system drug (CHEBI:35470)
tafamidis (CHEBI:78538) is a 1,3-benzoxazoles (CHEBI:51548)
tafamidis (CHEBI:78538) is a dichlorobenzene (CHEBI:23697)
tafamidis (CHEBI:78538) is a monocarboxylic acid (CHEBI:25384)
tafamidis (CHEBI:78538) is conjugate acid of tafamidis(1−) (CHEBI:79344)
Incoming tafamidis(1−) (CHEBI:79344) is conjugate base of tafamidis (CHEBI:78538)
2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid
INNs Sources
tafamidis KEGG DRUG
tafamidis WHO MedNet
tafamidis WHO MedNet
tafamidisum WHO MedNet
Synonyms Sources
2-(3,5-dichlorophenyl)benzoxazole-6-carboxylic acid ChemIDplus
Fx-1006 ChemIDplus
Manual Xrefs Databases
3MI PDBeChem
4192 DrugCentral
Tafamidis Wikipedia
WO2011131661 Patent
WO2013060668 Patent
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Registry Numbers Types Sources
594839-88-0 CAS Registry Number ChemIDplus
594839-88-0 CAS Registry Number KEGG DRUG
9496624 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
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Last Modified
22 February 2017