CHEBI:7823 - oxazepam

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ChEBI Name oxazepam
ChEBI ID CHEBI:7823
Definition A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a hydroxy group at position 3 and phenyl group at position 5.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C15H11ClN2O2
Net Charge 0
Average Mass 286.71300
Monoisotopic Mass 286.051
InChI InChI=1S/C15H11ClN2O2/c16-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)18-15(20)14(19)17-12/h1-8,15,20H,(H,17,19)
InChIKey ADIMAYPTOBDMTL-UHFFFAOYSA-N
SMILES OC1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O
Roles Classification
Chemical Role(s): environmental contaminant
Any minor or unwanted substance introduced into the environment that can have undesired effects.
Biological Role(s): xenobiotic
A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
(via benzodiazepine )
Application(s): anxiolytic drug
Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
(via benzodiazepine )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing oxazepam (CHEBI:7823) has role anxiolytic drug (CHEBI:35474)
oxazepam (CHEBI:7823) has role environmental contaminant (CHEBI:78298)
oxazepam (CHEBI:7823) has role xenobiotic (CHEBI:35703)
oxazepam (CHEBI:7823) is a 1,4-benzodiazepinone (CHEBI:35500)
oxazepam (CHEBI:7823) is a organochlorine compound (CHEBI:36683)
IUPAC Name
7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Synonyms Sources
(+-)-Oxazepam ChemIDplus
(RS)-Oxazepam ChemIDplus
Oxazepam KEGG COMPOUND
Serax ChemIDplus
Tazepam ChemIDplus
Manual Xrefs Databases
2015 DrugCentral
C07359 KEGG COMPOUND
CN1543961 Patent
D00464 KEGG DRUG
DB00842 DrugBank
HMDB0014980 HMDB
Oxazepam Wikipedia
View more database links
Registry Numbers Types Sources
604-75-1 CAS Registry Number KEGG COMPOUND
604-75-1 CAS Registry Number ChemIDplus
604-75-1 CAS Registry Number NIST Chemistry WebBook
754065 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
17456431 PubMed citation Europe PMC
9811432 PubMed citation Europe PMC
Last Modified
22 February 2017
General Comment
2014-10-29 Stravs M, Schymanski E, Singer H, Department of Environmental Chemistry, Eawag