CHEBI:76164 - lonazolac

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ChEBI Name lonazolac
ChEBI ID CHEBI:76164
Definition A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 3-(4-chlorophenyl)-1-phenylpyrazol-4-yl group.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C17H13ClN2O2
Net Charge 0
Average Mass 312.75000
Monoisotopic Mass 312.067
InChI InChI=1S/C17H13ClN2O2/c18-14-8-6-12(7-9-14)17-13(10-16(21)22)11-20(19-17)15-4-2-1-3-5-15/h1-9,11H,10H2,(H,21,22)
InChIKey XVUQHFRQHBLHQD-UHFFFAOYSA-N
SMILES OC(=O)Cc1cn(nc1-c1ccc(Cl)cc1)-c1ccccc1
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.
Application(s): non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
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ChEBI Ontology
Outgoing lonazolac (CHEBI:76164) has functional parent acetic acid (CHEBI:15366)
lonazolac (CHEBI:76164) has role antineoplastic agent (CHEBI:35610)
lonazolac (CHEBI:76164) has role EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor (CHEBI:35544)
lonazolac (CHEBI:76164) has role non-narcotic analgesic (CHEBI:35481)
lonazolac (CHEBI:76164) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
lonazolac (CHEBI:76164) is a monocarboxylic acid (CHEBI:25384)
lonazolac (CHEBI:76164) is a monochlorobenzenes (CHEBI:83403)
lonazolac (CHEBI:76164) is a pyrazoles (CHEBI:26410)
lonazolac (CHEBI:76164) is conjugate acid of lonazolac(1−) (CHEBI:76169)
Incoming lonazolac(1−) (CHEBI:76169) is conjugate base of lonazolac (CHEBI:76164)
IUPAC Name
[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]acetic acid
INNs Sources
lonazolac WHO MedNet
lonazolac KEGG DRUG
lonazolaco ChemIDplus
lonazolacum ChemIDplus
Synonym Source
3-(p-Chlorophenyl)-1-phenylpyrazole-4-acetic acid ChemIDplus
Manual Xrefs Databases
1597 DrugCentral
D07265 KEGG DRUG
Lonazolac Wikipedia
WO2008017903 Patent
View more database links
Registry Numbers Types Sources
53808-88-1 CAS Registry Number KEGG DRUG
53808-88-1 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
1878992 PubMed citation Europe PMC
2308057 PubMed citation Europe PMC
2370919 PubMed citation Europe PMC
2750201 PubMed citation Europe PMC
3539127 PubMed citation Europe PMC
358658 PubMed citation Europe PMC
3864763 PubMed citation Europe PMC
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9726694 PubMed citation Europe PMC
Last Modified
22 February 2017